{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T19:01:58Z","timestamp":1792263718337,"version":"4.4.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":193,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372390"],"award-info":[{"award-number":["82372390"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Special Project of Clinical Research for Health Industry from Shanghai Health Committee","award":["20214Y0323"],"award-info":[{"award-number":["20214Y0323"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic diabetic wounds persist because inflammation, oxidative stress and impaired angiogenesis create a hostile microenvironment. We developed an exosome-functionalized, aligned poly(lactic-co-glycolic acid)\/gelatin electrospun dressing (EE@PG) that serves as a local depot for sustained delivery of endothelial progenitor cell-derived exosomes. EE@PG scavenged hydroxyl and superoxide radicals and showed enzyme-mimetic antioxidant activity. Under lipopolysaccharide stimulation, EE@PG lowered intracellular reactive oxygen species, restored mitochondrial membrane potential and promoted RAW264.7 macrophage polarization toward a reparative phenotype while improving human umbilical vein endothelial cell viability and tube formation. In a splinted full-thickness STZ-induced diabetic rat model, EE@PG accelerated wound closure, enhanced re-epithelialization and collagen remodeling and increased neovascularization and vessel maturation. Transcriptomic analysis supported a shift toward immune resolution and tissue repair programs. Hemolysis, serum chemistry and organ histology indicated favorable biosafety. This work highlights a generalizable drug-delivering nanofibrous dressing that couples sustained exosome signaling with aligned structural cues for chronic wound management in clinically relevant settings.<\/jats:p>","DOI":"10.1093\/rb\/rbag116","type":"journal-article","created":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T11:39:52Z","timestamp":1783856392000},"source":"Crossref","is-referenced-by-count":0,"title":["Sustained\n                    <i>in situ<\/i>\n                    exosome delivery reprograms the diabetic wound microenvironment to unlock immuno-angiogenic repair"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0094-3722","authenticated-orcid":false,"given":"Ning","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai 200233,","place":["China"]},{"name":"Shanghai Eighth People\u2019s Hospital Department of Orthopaedic Surgery, , Shanghai 200235,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai Eighth People\u2019s Hospital , Shanghai 200235,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingliang","family":"Wei","sequence":"additional","affiliation":[{"name":"Shanghai Normal University College of Life Sciences, , Shanghai 200234,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingzhou","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai Eighth People\u2019s Hospital , Shanghai 200235,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai Eighth 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200233,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sa","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai 200233,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai 200233,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai 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