{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:42:41Z","timestamp":1792172561152,"version":"4.4.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":160,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202696"],"award-info":[{"award-number":["82202696"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Failure of rotator cuff repair largely stems from ineffective regeneration of the tendon\u2013bone interface (TBI), driven by persistent inflammation and excessive reactive oxygen species (ROS) accumulation at the biomaterial tissue interface. Here, we engineer an immunoregulatory suture interface by incorporating cerium-doped mesoporous bioactive glass nanoparticles (Ce-MBGNs) into a gelatin\/tannic acid (Gel\/TA) coating on polyethylene terephthalate sutures. The hierarchical Gel\/TA\/Ce-MBGN coating displays uniform morphology, robust adhesion and superior ROS scavenging activity. In vitro, Ce-MBGN-functionalized surfaces markedly promote osteogenic and chondrogenic differentiation of bone marrow mesenchymal stem cells, while polarizing macrophages toward an anti-inflammatory M2 phenotype and substantially reducing intracellular ROS. In a rat rotator cuff repair model, high Ce-MBGN-loaded sutures significantly enhance fibrocartilaginous enthesis regeneration, increase bone mineral density and elevate M2 macrophage infiltration at the TBI. These regenerative effects correlate with suppressed HIF-1\u03b1 expression in vivo, suggesting that localized redox modulation drives macrophage immunometabolic reprogramming to foster a pro-regenerative microenvironment. This Ce-MBGN-enabled interface engineering strategy simultaneously scavenges ROS, modulates immunity, and supports multi-lineage tissue regeneration at the TBI, offering a promising, clinically translatable approach for immunomodulatory suture design to improve rotator cuff repair outcomes.<\/jats:p>","DOI":"10.1093\/rb\/rbag121","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T11:21:36Z","timestamp":1780917696000},"source":"Crossref","is-referenced-by-count":2,"title":["ROS scavenging nanoengineered bioactive glass interfaces reprogram macrophage immunity for tendon\u2013bone regeneration"],"prefix":"10.1093","volume":"13","author":[{"given":"Bowen","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital with Nanjing Medical University , Nanjing 210029,","place":["China"]},{"name":"Jiangsu Institute of Functional Reconstruction and Rehabilitation, the First Affiliated Hospital with Nanjing Medical University , Nanjing 210029,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanrui","family":"Zeng","sequence":"additional","affiliation":[{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine & Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University , Nanjing 210029,","place":["China"]},{"name":"Affiliated Hospital of Stomatology, Nanjing Medical University , Nanjing 210029,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixiao","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital with Nanjing Medical University , Nanjing 210029,","place":["China"]},{"name":"Jiangsu Institute of Functional Reconstruction and Rehabilitation, the First Affiliated Hospital with Nanjing Medical University , Nanjing 210029,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital with Nanjing Medical University , Nanjing 210029,","place":["China"]},{"name":"Jiangsu Institute of Functional Reconstruction and Rehabilitation, the First Affiliated Hospital with Nanjing Medical University , Nanjing 210029,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital with Nanjing Medical University , Nanjing 210029,","place":["China"]},{"name":"Jiangsu Institute of Functional Reconstruction and Rehabilitation, the First Affiliated Hospital with Nanjing Medical University , Nanjing 210029,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Wu","sequence":"additional","affiliation":[{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine & Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University , Nanjing 210029,","place":["China"]},{"name":"Affiliated Hospital of Stomatology, Nanjing Medical University , Nanjing 210029,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Research Institute of Stomatology, Nanjing University , Nanjing 210029,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Anhui Province Engineering Research Center for Dental Materials and Application, School of Stomatology, Wannan Medical College , Wuhu 241002,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahin","family":"Homaeigohar","sequence":"additional","affiliation":[{"name":"School of Science and Engineering, University of Dundee , Dundee DD1 4HN,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2573-6677","authenticated-orcid":false,"given":"Kai","family":"Zheng","sequence":"additional","affiliation":[{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine & Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University , Nanjing 210029,","place":["China"]},{"name":"Affiliated Hospital of Stomatology, Nanjing Medical University , Nanjing 210029,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital with Nanjing Medical University , Nanjing 210029,","place":["China"]},{"name":"Jiangsu Institute of Functional Reconstruction and Rehabilitation, the First Affiliated Hospital with Nanjing Medical University , Nanjing 210029,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahu","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital with Nanjing Medical University , Nanjing 210029,","place":["China"]},{"name":"Jiangsu Institute of Functional Reconstruction and Rehabilitation, the First Affiliated Hospital with Nanjing Medical University , Nanjing 210029,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"2026070406414548600_rbag121-B1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.colsurfb.2017.06.004","article-title":"Biomaterials based strategies for rotator cuff 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Serial ultrasound examination after arthroscopic repair of large and massive rotator cuff tears","volume":"39","author":"Miller","year":"2011","journal-title":"Am J Sports Med"},{"key":"2026070406414548600_rbag121-B3","first-page":"85","article-title":"Biological approaches to the repair and regeneration of the rotator cuff tendon-bone enthesis: a literature review","volume":"4","author":"Abdalla","year":"2023","journal-title":"Biomater Transl"},{"key":"2026070406414548600_rbag121-B4","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1007\/s11926-014-0476-x","article-title":"Rotator cuff biology and biomechanics: a review of normal and pathological conditions","volume":"17","author":"Huegel","year":"2015","journal-title":"Curr Rheumatol Rep"},{"key":"2026070406414548600_rbag121-B5","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1136\/annrheumdis-2021-220256","article-title":"Single cell and spatial transcriptomics in human tendon disease indicate dysregulated immune 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