{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:32:44Z","timestamp":1791437564734,"version":"4.3.3"},"reference-count":59,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":161,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dental caries remains a prevalent global oral disease characterized by the progressive demineralization of dental hard tissues. Effective remineralization strategies are necessary to arrest its progression and repair the resulting structural damage. This study investigated a novel amelogenin-derived peptide, CaAm-P19, for biomimetic enamel remineralization. In vitro assays evaluated the peptide\u2019s cytocompatibility, structural stability and hydroxyapatite-binding affinity. The spatial distribution of fluorescein isothiocyanate-labeled CaAm-P19 was mapped using confocal microscopy, while overall remineralization efficacy was assessed in a demineralized bovine enamel model. Results indicated that CaAm-P19\u00a0was highly cytocompatible. BestSel deconvolution of circular dichroism spectra revealed that CaAm-P19 adopts a conformation dominated by random coils and \u03b2-sheets, and no statistically significant changes were detected following Ca2+ addition. Confocal imaging demonstrated continuous surface binding coupled with deep intralesional penetration exceeding 400\u2009\u03bcm. Furthermore, the peptide attenuated calcium dissolution during demineralization challenges and directed the deposition of ordered hydroxyapatite-like crystals. Notably, CaAm-P19 achieved microhardness comparable to that of fluoride and significantly higher mineral density recovery. It successfully reconstructed a homogeneous micro-architecture, yielding a stoichiometric calcium-to-phosphorus ratio approaching that of native enamel. In conclusion, by combining deep lesion infiltration with targeted mineral nucleation, CaAm-P19 represents a scientifically robust and promising bioactive agent for early caries management.<\/jats:p>","DOI":"10.1093\/rb\/rbag123","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:33:08Z","timestamp":1781004788000},"source":"Crossref","is-referenced-by-count":1,"title":["CaAm-P19: a novel amelogenin-derived peptide for enamel remineralization"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1303-4498","authenticated-orcid":false,"given":"Xiaoqian","family":"Ding","sequence":"first","affiliation":[{"name":"Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital , Hong Kong 999077,","place":["China"]},{"name":"Outpatient Department at Longfor Guangnian, The Affiliated Stomatological Hospital of Chongqing Medical University , Chongqing 401147,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Restorative Dental Sciences, Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital , Hong Kong 999077,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia Kar Yung","family":"Yiu","sequence":"additional","affiliation":[{"name":"Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital , Hong Kong 999077,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyi","family":"Shan","sequence":"additional","affiliation":[{"name":"Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital , Hong Kong 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