{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:33:19Z","timestamp":1787009599995,"version":"build-2736575974"},"reference-count":69,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":167,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372135"],"award-info":[{"award-number":["82372135"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Favorable osteogenesis and effective antibacterial activity are two essential requirements for ideal scaffolds in bone tissue engineering, particularly for infected bone defects. Herein, we developed a novel hydrogel system based on mineralized ultraviolet-responsive methacrylated chitosan hydrogel (CSMA) integrated with black phosphorus (BP) nanosheets exhibiting a photothermal effect. BP was incorporated into CSMA and subsequently subjected to in situ biomineralization to form a BP-loaded mineralized hydrogel (BP@CSMA\/CaCO3). The physicochemical and biological properties of BP@CSMA\/CaCO3 were systematically investigated in vitro. BP incorporation and CaCO3 mineralization improved hydrogel stability and enabled sustained Ca2+ and phosphorus ion release, thereby supporting an osteogenesis-favorable microenvironment. Under high-intensity near-infrared (NIR) irradiation, BP-containing hydrogels exhibited strong antibacterial activity, which was supported by both photothermal heating and singlet oxygen generation. Under mild NIR stimulation, BP@CSMA\/CaCO3 promoted bone mesenchymal stem cells (BMSCs) proliferation and osteogenic differentiation, with increased ALP activity and osteogenic gene expression. Transcriptomic analysis further suggested the involvement of cytoskeletal and immune-related regulation in the enhanced osteogenic response. The application of BP@CSMA\/CaCO3 in a calvarial defect model (in vivo) indicated its superior bone formation ability. These findings suggested that BP@CSMA\/CaCO3 integrated antibacterial activity, ion-mediated osteogenic support and NIR-responsive regulation had great potential for bone regeneration.<\/jats:p>","DOI":"10.1093\/rb\/rbag128","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:30:18Z","timestamp":1781613018000},"source":"Crossref","is-referenced-by-count":1,"title":["Black phosphorus-loaded mineralized UV-responsive chitosan hydrogel for enhanced osteogenesis and antibacterial activity"],"prefix":"10.1093","volume":"13","author":[{"given":"Xiaoying","family":"Xu","sequence":"first","affiliation":[{"name":"College of Life Sciences and Medicine, Zhejiang Sci-Tech University , Hangzhou 310018,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, School of Stomatology, China Medical University , Shenyang 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