{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T06:12:09Z","timestamp":1783750329111,"version":"3.55.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":166,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Spinal surgery, particularly spinal decompression and fusion surgery, commonly encounters intraoperative bleeding. Deep bleeding in the narrow operative area (e.g. bone marrow cavity and venous plexus) is a significant challenge for achieving accurate hemostasis with traditional strategies, posing a life-threatening risk. Herein, a novel dual-form hemostatic material (CMC-Gelatin, CG) composed of carboxymethyl cellulose (CMC) and gelatin is developed for non-compressible hemostasis in spinal surgery. For minor bleeding, CG in powder form reduces blood loss by 69.06% within a mouse bleeding model, demonstrating hemostatic efficacy comparable to that of the commercial Surgicel\u00ae powder, while exhibiting superior cytocompatibility. Notably, CG powder rapidly forms an injectable gel upon mixing with saline, making it suitable for severe bleeding in a confined space during spinal surgery. Specifically, in a pig paraspinal microvenous hemorrhage model, CG gel exhibits excellent hemostatic performance, reducing blood loss by 78.44% compared with the untreated group. Importantly, CG demonstrated a comparable hemostasis time and reduced blood loss in vivo compared to the commercial Surgiflo\u00ae. The designed CG materials exhibit outstanding hemostatic properties in deep, narrow areas, making them a promising hemostatic material in spinal surgery.<\/jats:p>","DOI":"10.1093\/rb\/rbag135","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:28:59Z","timestamp":1781612939000},"source":"Crossref","is-referenced-by-count":0,"title":["Dual-mode rapid hemostatic materials composed of gelatin and carboxymethyl cellulose for non-compressible bleeding in spinal surgery"],"prefix":"10.1093","volume":"13","author":[{"given":"Xiaoting","family":"Peng","sequence":"first","affiliation":[{"name":"Qingdao Municipal Hospital, Shandong Key Laboratory of Neurorehabilitation, Shandong Engineering Research Center for Tissue Rehabilitation Materials and Devices, Qingdao Key Laboratory of Smart Rehabilitation Material, School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences , Qingdao 266113,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingze","family":"Ji","sequence":"additional","affiliation":[{"name":"College of Medicine, Qingdao University , Qingdao 266071,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingcheng","family":"Fan","sequence":"additional","affiliation":[{"name":"College of Medicine, Qingdao University , Qingdao 266071,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuqiang","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, The Affiliated Hospital of Qingdao University , Qingdao 266003,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, The Affiliated Hospital of Qingdao University , Qingdao 266003,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyong","family":"Du","sequence":"additional","affiliation":[{"name":"Qingdao Municipal Hospital, Shandong Key Laboratory of Neurorehabilitation, Shandong Engineering Research Center for Tissue Rehabilitation Materials and Devices, Qingdao Key Laboratory of Smart Rehabilitation Material, School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences , Qingdao 266113,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guotai","family":"Li","sequence":"additional","affiliation":[{"name":"Qingdao Municipal Hospital, Shandong Key Laboratory of Neurorehabilitation, Shandong Engineering Research Center for Tissue Rehabilitation Materials and Devices, Qingdao Key Laboratory of Smart Rehabilitation Material, School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences , Qingdao 266113,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2474-4197","authenticated-orcid":false,"given":"Qihui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Qingdao Municipal Hospital, Shandong Key Laboratory of Neurorehabilitation, Shandong Engineering Research Center for Tissue Rehabilitation Materials and Devices, Qingdao Key Laboratory of Smart Rehabilitation Material, School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences , Qingdao 266113,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"2026071101161648000_rbag135-B1","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1001\/jama.2010.338","article-title":"Trends, major medical complications, and charges associated with surgery for lumbar spinal stenosis in older 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