{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T19:39:44Z","timestamp":1792352384323,"version":"4.4.0"},"reference-count":68,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":288,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Dental and Craniofacial Research (NIDCR) of the NIH","award":["R01 DE029204-01"],"award-info":[{"award-number":["R01 DE029204-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Craniomaxillofacial bone defects and implant-related infections require materials that support regeneration while providing localized therapeutic action. Quercetin offers osteogenic, antibacterial, and anticancer activity, but poor stability and bioavailability limit direct use. To address this, a Quercetin\u2013zinc (Q\u2013Zn2+) complex is loaded onto 3D-printed (3DP) tricalcium phosphate (TCP) scaffolds, where zinc coordination stabilizes Quercetin through metal-ligand interactions and enables controlled release. The release behavior of Q\u2013Zn2+ from 3DP TCP and its antibacterial effects remain unexplored. Characterization of the complex shows that Zn2+ chelates with Quercetin\u2019s hydroxyl and carbonyl groups. Release studies at pH 5.0 and pH 7.4 show sustained delivery of Quercetin over 24\u2009days, reaching 16% release at pH 5.0 and 5% at pH 7.4 for complexed Quercetin. In vitro evaluation shows that Q\u2013Zn2+-loaded scaffolds increase osteoblast viability by 42%, reduce osteosarcoma viability by \u223c55%, and achieve 93% inhibition of Staphylococcus aureus compared to TCP control. Zn2+ chelation stabilizes Quercetin release while improving osteoblast viability and suppressing bacterial and osteosarcoma growth from 3DP TCP scaffolds. This approach offers a route for controlled therapeutic delivery of Quercetin in calcium phosphate bone graft materials.<\/jats:p>","DOI":"10.1093\/rb\/rbag139","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:51:09Z","timestamp":1791978669000},"source":"Crossref","is-referenced-by-count":0,"title":["3D-printed tricalcium phosphate scaffolds with Quercetin-zinc chelation for osteogenic, antibacterial and anti-osteosarcoma activity"],"prefix":"10.1093","volume":"13","author":[{"given":"Susmita","family":"Bose","sequence":"first","affiliation":[{"name":"W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University , Pullman, WA 99164,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor","family":"Toulou","sequence":"additional","affiliation":[{"name":"W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University , Pullman, WA 99164,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Dahiya","sequence":"additional","affiliation":[{"name":"W. M. 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