{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T21:11:55Z","timestamp":1788988315327,"version":"build-2803163510"},"reference-count":58,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":201,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Guangxi Science and Technology Innovation Platform Plan","award":["LT2600640002"],"award-info":[{"award-number":["LT2600640002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Diabetic wound repair remains a considerable clinical challenge, largely due to the limited efficacy of current therapies. Herein, we engineered a novel silk fibroin (SF)\u2013polyethylene glycol (PEG) hydrogel (SPB) incorporated with berberine (BBR) and adipose-derived stem cells (ASCs) to synergistically promote diabetic wound healing. By optimizing the physicochemical properties of SPB, we found that a 7:3 SF:PEG ratio provided an ideal balance of pore size (25.83\u2009\u00b1\u20093.94\u2009\u03bcm), mechanical strength (32.33\u2009\u00b1\u20094.07\u2009kPa) and sustained BBR release. In vitro, SPB significantly enhanced ASC paracrine function, promoting the production of vascular endothelial growth factor (VEGF), fibroblast growth factor 2 (FGF-2), stromal cell-derived factor 1 (SDF-1), platelet-derived growth factor-BB (PDGF-BB), and transforming growth factor beta (TGF-\u03b2). Accordingly, SF-based hydrogel system (SPBA) markedly stimulated fibroblast proliferation and migration and enhanced endothelial cell angiogenesis. Moreover, SPBA effectively modulated macrophage repolarization from the pro-inflammatory M1 to the anti-inflammatory M2 phenotype, thereby suppressing inflammation. In vivo, SPBA demonstrated remarkable therapeutic efficacy in diabetic rat full-thickness skin wounds, accelerating wound closure, promoting re-epithelialization, collagen deposition and neovascularization, while reducing local inflammation. These results highlight SPBA as a highly efficient and promising biomaterial strategy for diabetic wound treatment.<\/jats:p>","DOI":"10.1093\/rb\/rbag151","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:22:25Z","timestamp":1784546545000},"source":"Crossref","is-referenced-by-count":0,"title":["Synergistic effects of berberine and adipose stem cells in a silk fibroin-PEG hydrogel for diabetic wound healing via macrophage polarization modulation"],"prefix":"10.1093","volume":"13","author":[{"given":"Xiaohao","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Plastic and Aesthetic Surgery, The People\u2019s Hospital of Guangxi Zhuang Autonomous Region & Research Center of Medical Sciences, Guangxi Academy of Medical Sciences , Nanning 530021,","place":["China"]},{"name":"Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University , Nanning 530021,","place":["China"]},{"name":"Collaborative Innovation Centre of Regenerative Medicine and Medical Bioresource Development and Application Co-constructed by the Province and Ministry, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University , Nanning 530021,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Xu","sequence":"additional","affiliation":[{"name":"Life Sciences Institute, Guangxi Medical University , Nanning 530021,","place":["China"]},{"name":"Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University , Nanning 530021,","place":["China"]},{"name":"Collaborative Innovation Centre of Regenerative Medicine and Medical Bioresource Development and Application Co-constructed by the Province and Ministry, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University , Nanning 530021,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Zhong","sequence":"additional","affiliation":[{"name":"Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University , Nanning 530021,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihao","family":"Zheng","sequence":"additional","affiliation":[{"name":"Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University , Nanning 530021,","place":["China"]},{"name":"Collaborative Innovation Centre of Regenerative Medicine and Medical Bioresource Development and Application Co-constructed by the Province and Ministry, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University , Nanning 530021,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chonglin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University , Nanning 530021,","place":["China"]},{"name":"Collaborative Innovation Centre of Regenerative Medicine and Medical Bioresource Development and Application Co-constructed by the Province and Ministry, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University , Nanning 530021,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuer","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic Surgery, The People\u2019s Hospital of Guangxi Zhuang Autonomous Region & Research Center of Medical Sciences, Guangxi Academy of Medical Sciences , Nanning 530021,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1321-3032","authenticated-orcid":false,"given":"Ke","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Plastic & Cosmetic Surgery, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University , Nanning 530021,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dacai","family":"Qu","sequence":"additional","affiliation":[{"name":"College of Agriculture, Guangxi University, Nanning 530004,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"College of Agriculture, Guangxi University, Nanning 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Guangxi Medical University , Nanning 530021,","place":["China"]},{"name":"Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University , Nanning 530021,","place":["China"]},{"name":"Collaborative Innovation Centre of Regenerative Medicine and Medical Bioresource Development and Application Co-constructed by the Province and Ministry, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University , Nanning 530021,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinming","family":"Zhao","sequence":"additional","affiliation":[{"name":"Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University , Nanning 530021,","place":["China"]},{"name":"Collaborative Innovation Centre of Regenerative Medicine and Medical 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