{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:29:41Z","timestamp":1788791381025,"version":"build-2803163510"},"reference-count":39,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":202,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52532008"],"award-info":[{"award-number":["52532008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"R&D Program of Zhejiang","award":["2024C03080"],"award-info":[{"award-number":["2024C03080"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Implant-associated infection remains a critical challenge for orthopedic implants, particularly for bioinert polyetheretherketone (PEEK), which also requires improved osteogenic support. Here, we developed a heterostructured surface on PEEK by coupling a graphite-like layer with a defect-rich TaOx nanoarray. The graphite-like layer promoted uniform TaOx nanoarray formation and may facilitate interfacial electronic coupling, while the TaOx nanoarray showed polarity-dependent and interface-limited charge-transport behavior in model electrical tests. Upon bacterial contact, the heterostructure produced a bacteria-associated 3,3\u2032,5,5\u2032-tetramethylbenzidine (TMB) oxidative response and markedly decreased bacterial ATP levels, leading to broad-spectrum antibacterial performance. Thermal annealing attenuated defect-associated TaOx states and weakened antibacterial activity, supporting the involvement of defect-related interfacial states in the antibacterial process. Meanwhile, Ta\/H-PEEK supported osteoblast proliferation and osteogenic differentiation in vitro and promoted peri-implant bone formation in vivo. The surface also reduced early bacterial burden in a rat infection model. Collectively, this work demonstrates a heterostructure-based PEEK surface strategy to integrate antibacterial activity with osteogenic compatibility.<\/jats:p>","DOI":"10.1093\/rb\/rbag152","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T11:58:32Z","timestamp":1784721512000},"source":"Crossref","is-referenced-by-count":0,"title":["Designing a heterostructure of graphite-like layer\/TaOx on polyetheretherketone for selective antibacteria and osteogenesis"],"prefix":"10.1093","volume":"13","author":[{"given":"Shuaiqi","family":"Jiang","sequence":"first","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050,","place":["China"]},{"name":"Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences , Beijing 100049,","place":["China"]},{"name":"School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences , Hangzhou 310024,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Ke","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050,","place":["China"]},{"name":"Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences , Beijing 100049,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yisi","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050,","place":["China"]},{"name":"Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences , Beijing 100049,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Pan","sequence":"additional","affiliation":[{"name":"Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences , Beijing 100049,","place":["China"]},{"name":"School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences , Hangzhou 310024,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongrui","family":"Cai","sequence":"additional","affiliation":[{"name":"Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences , Beijing 100049,","place":["China"]},{"name":"School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences , Hangzhou 310024,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiwei","family":"Guan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Tan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9440-8143","authenticated-orcid":false,"given":"Xuanyong","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics, Shanghai Institute of 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