{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:56:26Z","timestamp":1791042986717,"version":"4.1.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":215,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671843"],"award-info":[{"award-number":["81671843"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chongqing Natural Science Foundation","award":["CSTB2023NSCQ-MSX0426"],"award-info":[{"award-number":["CSTB2023NSCQ-MSX0426"]}]},{"name":"Chongqing Young and Middle-aged Medical High-end Talent","award":["YXGD202459"],"award-info":[{"award-number":["YXGD202459"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Despite the widespread use of various bone repair materials, ideal scaffolds with excellent cell adhesion and satisfactory osteogenesis are still urgently needed for bone defect regeneration. The self-assembling peptide RADA16\u2011I hydrogel has been widely used for bone defect repair owing to its excellent biocompatibility and favorable cytocompatibility, yet its application is limited by insufficient osteogenesis and weak cell adhesion. In this study, a novel peptide RADA16\u2011TRSAW was designed by conjugating the positively charged osteogenic short peptide TRSAW to RADA16\u2011I via solid-phase synthesis. TRSAWmax (mixture of RADA16\u2011TRSAW and RADA16\u2011I as 1:1) carried a net positive charge, maintained a stable \u03b2\u2011sheet secondary structure, retained self-assembly capability, and readily formed a hydrogel in PBS. The resulting hydrogel showed a microstructure and rheological properties similar to those of RADA16\u2011I hydrogel, suitable for cell growth, but with significantly enhanced cell adhesion owing to cationic arginine residues. RNA\u2011seq confirmed the upregulation of adhesion-related genes and pathways. Moreover, TRSAWmax exhibited excellent biocompatibility, promoted hMSC osteogenic differentiation through the Src\u2011Erk pathway in vitro, and demonstrated superior osteogenic capability in vivo. This work provides a highly adhesive and osteogenic peptide hydrogel candidate for accelerating bone tissue regeneration.<\/jats:p>","DOI":"10.1093\/rb\/rbag162","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T11:20:07Z","timestamp":1785756007000},"source":"Crossref","is-referenced-by-count":0,"title":["Cation-surface RADA16-based self-assembling peptide hydrogel with high adhesion and osteogenesis promoting\u00a0bone regeneration"],"prefix":"10.1093","volume":"13","author":[{"given":"Jiangling","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]},{"name":"Chongqing Engineering Research Center for Advanced Material Design and Intelligent Manufacturing in Bone Repair and Reconstruction, Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]},{"name":"National & Regional United Engineering Lab of Tissue Engineering, Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Gou","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]},{"name":"National & Regional United Engineering Lab of Tissue Engineering, Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]},{"name":"Department of Human Anatomy and Histology\u2011Embryology, Basic Medical Division, Sichuan College of Traditional Chinese Medicine , Mianyang 610065,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiandong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]},{"name":"Chongqing Engineering Research Center for Advanced Material Design and Intelligent Manufacturing in Bone Repair and Reconstruction, Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]},{"name":"National & Regional United Engineering Lab of Tissue Engineering, Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihao","family":"He","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]},{"name":"Chongqing Engineering Research Center for Advanced Material Design and Intelligent Manufacturing in Bone Repair and Reconstruction, Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]},{"name":"National & Regional United Engineering Lab of Tissue Engineering, Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]},{"name":"Chongqing Engineering Research Center for Advanced Material Design and Intelligent Manufacturing in Bone Repair and Reconstruction, Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]},{"name":"National & Regional United Engineering Lab of Tissue Engineering, Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiankun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]},{"name":"Chongqing Engineering Research Center for Advanced Material Design and Intelligent Manufacturing in Bone Repair and Reconstruction, Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]},{"name":"National & Regional United Engineering Lab of Tissue Engineering, Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]},{"name":"Chongqing Engineering Research Center for Advanced Material Design and Intelligent Manufacturing in Bone Repair and Reconstruction, Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]},{"name":"National & Regional United Engineering Lab of Tissue Engineering, Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4724-9180","authenticated-orcid":false,"given":"Qijie","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]},{"name":"Chongqing Engineering Research Center for Advanced Material Design and Intelligent Manufacturing in Bone Repair and Reconstruction, Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]},{"name":"National & Regional United Engineering Lab of Tissue Engineering, Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiulin","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]},{"name":"Chongqing Engineering Research Center for Advanced Material Design and Intelligent Manufacturing in Bone Repair and Reconstruction, Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]},{"name":"National & Regional United Engineering Lab of Tissue Engineering, Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingtao","family":"Gui","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]},{"name":"Chongqing Engineering Research Center for Advanced Material Design and Intelligent Manufacturing in Bone Repair and Reconstruction, Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]},{"name":"National & Regional United Engineering Lab of Tissue Engineering, Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, 958th Hospital of Chinese People\u2019s Liberation Army (Third Military Medical University) , Chongqing 400038,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junchao","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]},{"name":"Chongqing Engineering Research Center for Advanced Material Design and Intelligent Manufacturing in Bone Repair and Reconstruction, Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]},{"name":"National & Regional United Engineering Lab of Tissue Engineering, Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7685-2088","authenticated-orcid":false,"given":"Tianyong","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]},{"name":"Chongqing Engineering Research Center for Advanced Material Design and Intelligent Manufacturing in Bone Repair and Reconstruction, Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]},{"name":"National & Regional United Engineering Lab of Tissue Engineering, Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing 400038,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"2026100311413548700_rbag162-B1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/s41572-021-00289-8","article-title":"Non-union bone fractures","volume":"7","author":"Wildemann","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"2026100311413548700_rbag162-B2","doi-asserted-by":"crossref","first-page":"e14461","DOI":"10.1002\/adma.202514461","article-title":"Enzyme-programmable DNA-PEG hydrogel spatiotemporally regulates bone regeneration microenvironment","volume":"38","author":"Wu","year":"2026","journal-title":"Adv Mater"},{"key":"2026100311413548700_rbag162-B3","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1016\/j.injury.2021.01.043","article-title":"Autologous bone graft: is it still the gold standard?","volume":"52","author":"Schmidt","year":"2021","journal-title":"Injury"},{"key":"2026100311413548700_rbag162-B4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13287-024-03635-1","article-title":"Regenerative therapies for femoral head necrosis in the past two decades: a systematic review and network meta-analysis","volume":"15","author":"Wang","year":"2024","journal-title":"Stem Cell Res Ther"},{"key":"2026100311413548700_rbag162-B5","first-page":"156","article-title":"Bone\/cartilage targeted hydrogel: strategies and applications","volume":"23","author":"Zhang","year":"2023","journal-title":"Bioact Mater"},{"key":"2026100311413548700_rbag162-B6","doi-asserted-by":"crossref","first-page":"e2202766","DOI":"10.1002\/adhm.202202766","article-title":"Bone tissue engineering scaffolds: function of multi-material hierarchically structured scaffolds","volume":"12","author":"Koushik","year":"2023","journal-title":"Adv Healthc Mater"},{"key":"2026100311413548700_rbag162-B7","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1089\/ten.teb.2021.0147","article-title":"Cell-derived extracellular matrix materials for tissue engineering","volume":"28","author":"Guan","year":"2022","journal-title":"Tissue Eng Part B Rev"},{"key":"2026100311413548700_rbag162-B8","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.7150\/thno.97335","article-title":"Bioinspired soft-hard combined system with mild photothermal therapeutic activity promotes diabetic bone defect healing via synergetic effects of immune activation and angiogenesis","volume":"14","author":"Wu","year":"2024","journal-title":"Theranostics"},{"key":"2026100311413548700_rbag162-B9","doi-asserted-by":"crossref","first-page":"7140","DOI":"10.7150\/thno.102779","article-title":"Multifunctional injectable hydrogel system as a mild photothermal-assisted therapeutic platform for programmed regulation of inflammation and osteo-microenvironment for enhanced healing of diabetic bone defects in situ","volume":"14","author":"Zhu","year":"2024","journal-title":"Theranostics"},{"key":"2026100311413548700_rbag162-B10","doi-asserted-by":"crossref","first-page":"e2300111","DOI":"10.1002\/smll.202300111","article-title":"Mild photothermal-stimulation based on injectable and photocurable hydrogels orchestrates immunomodulation and osteogenesis for high-performance bone regeneration","volume":"19","author":"Wu","year":"2023","journal-title":"Small"},{"key":"2026100311413548700_rbag162-B11","doi-asserted-by":"crossref","first-page":"e10733","DOI":"10.1002\/smll.202510733","article-title":"Polyphenol-derived nanoarmor-functionalized photothermal hydrogel platform for programmed modulation of the regenerative microenvironment and bone defect healing","volume":"22","author":"Yang","year":"2026","journal-title":"Small"},{"key":"2026100311413548700_rbag162-B12","doi-asserted-by":"crossref","first-page":"e2304641","DOI":"10.1002\/advs.202304641","article-title":"Smart-responsive multifunctional therapeutic system for improved regenerative microenvironment and accelerated bone regeneration via mild photothermal therapy","volume":"11","author":"Wu","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"2026100311413548700_rbag162-B13","first-page":"291","article-title":"AI accelerated discovery of self-assembling peptides","volume":"4","author":"Shi","year":"2023","journal-title":"Biomater Transl"},{"key":"2026100311413548700_rbag162-B14","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/9783527825820.ch5","volume-title":"Multifunctional Hydrogels for Biomedical Applications","author":"Yuan","year":"2022"},{"key":"2026100311413548700_rbag162-B15","first-page":"395","volume-title":"Peptide- Based Biomaterials","author":"Shi","year":"2021"},{"key":"2026100311413548700_rbag162-B16","doi-asserted-by":"crossref","first-page":"13434","DOI":"10.1021\/acs.chemrev.0c00690","article-title":"Self-assembling peptide EAK16 and RADA16 nanofiber scaffold hydrogel","volume":"120","author":"Gelain","year":"2020","journal-title":"Chem Rev"},{"key":"2026100311413548700_rbag162-B17","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.addr.2020.10.005","article-title":"Synthetic peptide hydrogels as 3D scaffolds for tissue engineering","volume":"160","author":"Ding","year":"2020","journal-title":"Adv Drug Deliv Rev"},{"key":"2026100311413548700_rbag162-B18","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1016\/j.msec.2013.04.019","article-title":"Bone induction by biomimetic PLGA copolymer loaded with a novel synthetic RADA16-P24 peptide","volume":"33","author":"Pan","year":"2013","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"2026100311413548700_rbag162-B19","doi-asserted-by":"crossref","first-page":"e119","DOI":"10.1371\/journal.pone.0000119","article-title":"Designer self-assembling peptide nanofiber scaffolds for adult mouse neural stem cell 3-dimensional cultures","volume":"1","author":"Gelain","year":"2006","journal-title":"PLoS One"},{"key":"2026100311413548700_rbag162-B20","doi-asserted-by":"crossref","first-page":"421954","DOI":"10.1155\/2014\/421954","article-title":"Designer self-assembling peptide nanofiber scaffolds containing link protein N-terminal peptide induce chondrogenesis of rabbit bone marrow stem cells","volume":"2014","author":"Wang","year":"2014","journal-title":"Biomed Res Int"},{"key":"2026100311413548700_rbag162-B21","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.actbio.2016.09.001","article-title":"Transplantation of RADA16-BDNF peptide scaffold with human umbilical cord mesenchymal stem cells forced with CXCR4 and activated astrocytes for repair of traumatic brain injury","volume":"45","author":"Shi","year":"2016","journal-title":"Acta Biomater"},{"key":"2026100311413548700_rbag162-B22","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.bbrc.2017.07.056","article-title":"Mesenchymal stem cell transplantation carried in SVVYGLR modified self-assembling peptide promoted cardiac repair and angiogenesis after myocardial infarction","volume":"491","author":"Gao","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"key":"2026100311413548700_rbag162-B23","first-page":"181","article-title":"A parathyroid hormone related supramolecular peptide for multi-functionalized osteoregeneration","volume":"34","author":"Hao","year":"2024","journal-title":"Bioact Mater"},{"key":"2026100311413548700_rbag162-B24","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/jcp.1041580317","article-title":"C-terminal fragments of parathyroid hormone-related protein, PTHrP-(107-111) and (107-139), and the N-terminal PTHrP-(1-40) fragment stimulate membrane-associated protein kinase C activity in rat spleen lymphocytes","volume":"158","author":"Whitfield","year":"2005","journal-title":"J Cell Physiol"},{"key":"2026100311413548700_rbag162-B25","doi-asserted-by":"crossref","first-page":"116177","DOI":"10.1016\/j.bcp.2024.116177","article-title":"Osteostatin, a peptide for the future treatment of musculoskeletal diseases","volume":"223","author":"Lozano","year":"2024","journal-title":"Biochem Pharmacol"},{"key":"2026100311413548700_rbag162-B26","doi-asserted-by":"crossref","first-page":"6889","DOI":"10.1080\/07391102.2021.1891140","article-title":"Identification of novel allosteric binding sites and multi-targeted allosteric inhibitors of receptor and non-receptor tyrosine kinases using a computational approach","volume":"40","author":"Kakarala","year":"2022","journal-title":"J Biomol Struct Dyn"},{"key":"2026100311413548700_rbag162-B27","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1002\/jcp.22902","article-title":"Comparison of the skeletal effects induced by daily administration of PTHrP (1-36) and PTHrP (107-139) to ovariectomized mice","volume":"227","author":"de Castro","year":"2012","journal-title":"J Cell Physiol"},{"key":"2026100311413548700_rbag162-B28","doi-asserted-by":"crossref","first-page":"617","DOI":"10.2131\/jts.37.617","article-title":"Osteosarcoma in Sprague-Dawley rats after long-term treatment with teriparatide (human parathyroid hormone (1-34))","volume":"37","author":"Watanabe","year":"2012","journal-title":"J Toxicol Sci"},{"key":"2026100311413548700_rbag162-B29","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.actbio.2009.08.033","article-title":"Osteostatin-loaded bioceramics stimulate osteoblastic growth and differentiation","volume":"6","author":"Lozano","year":"2010","journal-title":"Acta Biomater"},{"key":"2026100311413548700_rbag162-B30","doi-asserted-by":"crossref","first-page":"8564","DOI":"10.1016\/j.biomaterials.2010.07.103","article-title":"The osteoinductive properties of mesoporous silicate coated with osteostatin in a rabbit femur cavity defect model","volume":"31","author":"Trejo","year":"2010","journal-title":"Biomaterials"},{"key":"2026100311413548700_rbag162-B31","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1016\/j.actbio.2012.04.002","article-title":"Osteostatin improves the osteogenic activity of fibroblast growth factor-2 immobilized in Si-doped hydroxyapatite in osteoblastic cells","volume":"8","author":"Lozano","year":"2012","journal-title":"Acta Biomater"},{"key":"2026100311413548700_rbag162-B32","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ocl.2023.05.011","article-title":"Maximizing implant stability in the face of glenoid bone stock deficiency","volume":"55","author":"Smith","year":"2024","journal-title":"Orthop Clin North Am"},{"key":"2026100311413548700_rbag162-B33","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.jare.2025.08.058","article-title":"A rapidly fabricated bone marrow enrichment material with a controllable pore size promotes osteogenesis close to autogenous bone graft in clinic","volume":"84","author":"Yang","year":"2026","journal-title":"J Adv Res"},{"key":"2026100311413548700_rbag162-B34","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jot.2018.11.006","article-title":"Bioactive scaffolds for osteochondral regeneration","volume":"17","author":"Deng","year":"2019","journal-title":"J Orthop Translat"},{"key":"2026100311413548700_rbag162-B35","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s42242-021-00149-0","article-title":"Recent advances in design and applications of biomimetic self-assembled peptide hydrogels for hard tissue regeneration","volume":"4","author":"Najafi","year":"2021","journal-title":"Biodes Manuf"},{"key":"2026100311413548700_rbag162-B36","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1007\/s00264-014-2388-9","article-title":"Bone marrow enriched graft, modified by self-assembly peptide, repairs critically-sized femur defects in goats","volume":"38","author":"Li","year":"2014","journal-title":"Int Orthop"},{"key":"2026100311413548700_rbag162-B37","doi-asserted-by":"crossref","first-page":"5689","DOI":"10.1016\/j.biomaterials.2014.03.079","article-title":"A composite demineralized bone matrix - self assembling peptide scaffold for enhancing cell and growth factor activity in bone marrow","volume":"35","author":"Hou","year":"2014","journal-title":"Biomaterials"},{"key":"2026100311413548700_rbag162-B38","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.addr.2015.04.007","article-title":"Extracellular matrix-inspired growth factor delivery systems for bone regeneration","volume":"94","author":"Martino","year":"2015","journal-title":"Adv Drug Deliv Rev"},{"key":"2026100311413548700_rbag162-B39","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1152\/physrev.00031.2015","article-title":"Parathyroid Hormone-Related protein, its regulation of cartilage and bone development, and role in treating bone diseases","volume":"96","author":"Martin","year":"2016","journal-title":"Physiol Rev"},{"key":"2026100311413548700_rbag162-B40","doi-asserted-by":"crossref","first-page":"e2301604","DOI":"10.1002\/adhm.202301604","article-title":"A novel PTH-related peptide combined with 3D printed macroporous titanium alloy scaffold enhances osteoporotic osseointegration","volume":"12","author":"Wang","year":"2023","journal-title":"Adv Healthcare Mater"},{"key":"2026100311413548700_rbag162-B41","doi-asserted-by":"crossref","first-page":"113959","DOI":"10.1016\/j.colsurfb.2024.113959","article-title":"Transforming growth factor-\u03b21-loaded RADA-16 hydrogel scaffold for effective cartilage regeneration","volume":"239","author":"Yu","year":"2024","journal-title":"Colloids Surf B Biointerfaces"},{"key":"2026100311413548700_rbag162-B42","doi-asserted-by":"crossref","first-page":"015007","DOI":"10.1088\/1748-605X\/12\/1\/015007","article-title":"Self-assembly behaviors of molecular designer functional RADA16-I peptides: influence of motifs, pH, and assembly time","volume":"12","author":"Sun","year":"2016","journal-title":"Biomed Mater"},{"key":"2026100311413548700_rbag162-B43","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00068-020-01324-1","article-title":"Electrical stimulation in bone tissue engineering treatments","volume":"46","author":"Leppik","year":"2020","journal-title":"Eur J Trauma Emerg Surg"},{"key":"2026100311413548700_rbag162-B44","first-page":"4","article-title":"Signaling pathways implicated in enhanced stem\/progenitor cell differentiation on electroactive scaffolds","volume":"3","author":"Heng","year":"2022","journal-title":"Smart Mater Med"},{"key":"2026100311413548700_rbag162-B45","doi-asserted-by":"crossref","first-page":"2004393","DOI":"10.1002\/advs.202004393","article-title":"Biomedical implants with charge-transfer monitoring and regulating abilities","volume":"8","author":"Wang","year":"2021","journal-title":"Advanced Science"},{"key":"2026100311413548700_rbag162-B46","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.actbio.2018.04.051","article-title":"Surface potential-governed cellular osteogenic differentiation on ferroelectric polyvinylidene fluoride trifluoroethylene films","volume":"74","author":"Tang","year":"2018","journal-title":"Acta Biomater"},{"key":"2026100311413548700_rbag162-B47","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1002\/jbm.b.34884","article-title":"Enhanced osteogenic differentiation of mesenchymal stem cells on P(VDF-TrFE) layer coated microelectrodes","volume":"109","author":"Shen","year":"2021","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"2026100311413548700_rbag162-B48","doi-asserted-by":"crossref","first-page":"44111","DOI":"10.1021\/acsami.2c11131","article-title":"Enhanced cell osteogenesis and osteoimmunology regulated by piezoelectric biomaterials with controllable surface potential and charges","volume":"14","author":"Mao","year":"2022","journal-title":"ACS Appl Mater Interfaces"},{"key":"2026100311413548700_rbag162-B49","doi-asserted-by":"crossref","first-page":"6004","DOI":"10.1016\/j.biomaterials.2010.04.013","article-title":"Bone regeneration mediated by biomimetic mineralization of a nanofiber matrix","volume":"31","author":"Mata","year":"2010","journal-title":"Biomaterials"},{"key":"2026100311413548700_rbag162-B50","doi-asserted-by":"crossref","first-page":"903","DOI":"10.3727\/000000006783981369","article-title":"Pura matrix facilitates bone regeneration in bone defects of calvaria in mice","volume":"15","author":"Misawa","year":"2006","journal-title":"Cell Transplant"},{"key":"2026100311413548700_rbag162-B51","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.msec.2016.12.042","article-title":"Designer bFGF-incorporated d-form self-assembly peptide nanofiber scaffolds to promote bone repair","volume":"74","author":"He","year":"2017","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"2026100311413548700_rbag162-B52","doi-asserted-by":"crossref","first-page":"e283","DOI":"10.11607\/jomi.te09","article-title":"Effects of self-assembling peptide hydrogel scaffold on bone regeneration with recombinant human bone morphogenetic protein-2","volume":"28","author":"Ikeno","year":"2013","journal-title":"Int J Oral Maxillofac Implants"},{"key":"2026100311413548700_rbag162-B53","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.2147\/DDDT.S97530","article-title":"Functionalized d-form self-assembling peptide hydrogels for bone regeneration","volume":"10","author":"He","year":"2016","journal-title":"Drug Des Devel Ther"},{"key":"2026100311413548700_rbag162-B54","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.bcp.2013.03.002","article-title":"Current perspectives on parathyroid hormone (PTH) and PTH-related protein (PTHrP) as bone anabolic therapies","volume":"85","author":"Esbrit","year":"2013","journal-title":"Biochem Pharmacol"},{"key":"2026100311413548700_rbag162-B55","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1002\/jcb.24482","article-title":"Src kinases mediate VEGFR2 transactivation by the osteostatin domain of PTHrP to modulate osteoblastic function","volume":"114","author":"Garc\u00eda-Mart\u00edn","year":"2013","journal-title":"J Cell Biochem"}],"container-title":["Regenerative Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/rb\/advance-article-pdf\/doi\/10.1093\/rb\/rbag162\/70478761\/rbag162.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/rb\/article-pdf\/doi\/10.1093\/rb\/rbag162\/70478761\/rbag162.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/rb\/article-pdf\/doi\/10.1093\/rb\/rbag162\/70478761\/rbag162.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:41:58Z","timestamp":1791042118000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/rb\/article\/doi\/10.1093\/rb\/rbag162\/8750957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":55,"URL":"https:\/\/doi.org\/10.1093\/rb\/rbag162","relation":{},"ISSN":["2056-3418","2056-3426"],"issn-type":[{"value":"2056-3418","type":"print"},{"value":"2056-3426","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"rbag162"}}