{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:56:32Z","timestamp":1791042992456,"version":"4.1.0"},"reference-count":176,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":231,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Xiamen Municipal Guiding Project for Medical and Health Care","award":["3502Z20224ZD1326"],"award-info":[{"award-number":["3502Z20224ZD1326"]}]},{"name":"Plan on Enhancing Scientific Research in GMU","award":["2024SRP125"],"award-info":[{"award-number":["2024SRP125"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301100"],"award-info":[{"award-number":["82301100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Joint Funds for the Innovation of Science and Technology, Fujian Province","award":["2024Y9680"],"award-info":[{"award-number":["2024Y9680"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Periodontitis is a prevalent chronic inflammatory disease and a major cause of tooth loss and systemic complications. Due to its progressive, often asymptomatic nature, substantial destruction of the cementum, periodontal ligament and alveolar bone is frequently present at the time of diagnosis, highlighting the urgent need for functional periodontal regeneration. Conventional biomaterials primarily serve as passive scaffolds and rarely enable the coordinated regeneration of multiple periodontal tissues. Recently, smart biomaterials have emerged as a promising strategy to address these limitations. By integrating stimulus responsiveness, bio-instructive and immunomodulatory functions and spatiotemporal control of therapeutic cues, these materials could dynamically interact with the diseased microenvironment to enhance regenerative outcomes for future periodontal therapy. In this review, we summarize the key biological and mechanistic barriers to periodontal regeneration, including multi-tissue coordination, microbial challenges, dysregulated inflammation and mechanical loading. We discuss how smart biomaterials are designed to overcome these obstacles through microenvironment-responsive delivery, immune modulation and interface-oriented regeneration. Finally, we highlight key design principles, evaluation frameworks and the translational relevance of animal models for periodontal biomaterials development. Smart biomaterials represent a transition from passive scaffolds to dynamic, immuno-instructive systems for periodontal regeneration.<\/jats:p>","DOI":"10.1093\/rb\/rbag182","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T11:46:27Z","timestamp":1787139987000},"source":"Crossref","is-referenced-by-count":0,"title":["Reimagining periodontal regeneration: smart biomaterials for a complex tissue landscape"],"prefix":"10.1093","volume":"13","author":[{"given":"Ming","family":"Liu","sequence":"first","affiliation":[{"name":"Xiamen Key Laboratory of Stomatological Disease Diagnosis and Treatment, Stomatological Hospital of Xiamen Medical College , Xiamen 361008,","place":["China"]},{"name":"School of Medicine and Dentistry, Griffith University , Queensland, QLD 4222,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Chen","sequence":"additional","affiliation":[{"name":"Xiamen Key Laboratory of Stomatological Disease Diagnosis and Treatment, Stomatological Hospital of Xiamen Medical College , Xiamen 361008,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Li","sequence":"additional","affiliation":[{"name":"Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University , Nanjing 210000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University , Guangzhou 510150,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1785-3491","authenticated-orcid":false,"given":"Yin","family":"Xiao","sequence":"additional","affiliation":[{"name":"School of Medicine and Dentistry, Griffith University , Queensland, QLD 4222,","place":["Australia"]},{"name":"Institute for Biomedicine and Glycomics, Griffith University , Queensland, QLD 4222,","place":["Australia"]},{"name":"Australian Centre for Precision Health and Technology (PRECISE), Griffith University , Queensland, QLD 4222,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"2026100311413518800_rbag182-B1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/jcpe.12732","article-title":"Impact of the global burden of periodontal diseases on health, nutrition and wellbeing of mankind: a call for global action","volume":"44","author":"Tonetti","year":"2017","journal-title":"J Clin Periodontol"},{"key":"2026100311413518800_rbag182-B2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12344","article-title":"Clinical and public health implications of periodontal and systemic diseases: an overview","volume":"83","author":"Genco","year":"2020","journal-title":"Periodontol 2000"},{"key":"2026100311413518800_rbag182-B3","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/prd.12246","article-title":"Experimental and clinical studies on regenerative periodontal therapy","volume":"79","author":"Sallum","year":"2019","journal-title":"Periodontol 2000"},{"key":"2026100311413518800_rbag182-B4","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/prd.12048","article-title":"Clinical concepts for regenerative therapy in intrabony defects","volume":"68","author":"Cortellini","year":"2015","journal-title":"Periodontol 2000"},{"key":"2026100311413518800_rbag182-B5","doi-asserted-by":"crossref","first-page":"S108","DOI":"10.1902\/jop.2015.130677","article-title":"Periodontal regeneration - furcation defects: a systematic review from the AAP regeneration workshop","volume":"86","author":"Avila-Ortiz","year":"2015","journal-title":"J Periodontol"},{"key":"2026100311413518800_rbag182-B6","doi-asserted-by":"crossref","first-page":"123714","DOI":"10.1016\/j.biomaterials.2025.123714","article-title":"Biomaterials-based strategy for dental-oral tissue regeneration: current clinical application, laboratory development, and future direction","volume":"326","author":"Li","year":"2026","journal-title":"Biomaterials"},{"key":"2026100311413518800_rbag182-B7","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12903-019-0766-9","article-title":"Early wound healing outcomes after regenerative periodontal surgery with enamel matrix derivatives or guided tissue regeneration: a systematic review","volume":"19","author":"Rojas","year":"2019","journal-title":"BMC Oral Health"},{"key":"2026100311413518800_rbag182-B8","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s00784-024-05643-0","article-title":"Early periodontal wound healing after chlorhexidine rinsing: a randomized clinical trial","volume":"28","author":"Graziani","year":"2024","journal-title":"Clin Oral Investig"},{"key":"2026100311413518800_rbag182-B9","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.3390\/jpm12101743","article-title":"Next-generation examination, diagnosis, and personalized medicine in periodontal disease","volume":"12","author":"Kikuchi","year":"2022","journal-title":"J Pers Med"},{"key":"2026100311413518800_rbag182-B10","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.3390\/ma12132197","article-title":"New perspectives in the use of biomaterials for periodontal regeneration","volume":"12","author":"Ausenda","year":"2019","journal-title":"Materials (Basel)"},{"key":"2026100311413518800_rbag182-B11","doi-asserted-by":"crossref","first-page":"841","DOI":"10.3390\/membranes12090841","article-title":"The use of biocompatible membranes in oral surgery: the past, present & future directions. A narrative review","volume":"12","author":"Kormas","year":"2022","journal-title":"Membranes (Basel)"},{"key":"2026100311413518800_rbag182-B12","doi-asserted-by":"crossref","first-page":"e23501","DOI":"10.1002\/dvg.23501","article-title":"Advanced biomaterials for periodontal tissue regeneration","volume":"60","author":"Daghrery","year":"2022","journal-title":"Genesis"},{"key":"2026100311413518800_rbag182-B13","first-page":"292","article-title":"3D printing of bio-instructive materials: toward directing the cell","volume":"19","author":"Zieli\u0144ski","year":"2023","journal-title":"Bioact Mater"},{"key":"2026100311413518800_rbag182-B14","doi-asserted-by":"crossref","first-page":"e1701061","DOI":"10.1002\/adhm.201701061","article-title":"Current approaches to bone tissue engineering: the interface between biology and engineering","volume":"7","author":"Li","year":"2018","journal-title":"Adv Healthc Mater"},{"key":"2026100311413518800_rbag182-B15","doi-asserted-by":"crossref","first-page":"101855","DOI":"10.1016\/j.mtbio.2025.101855","article-title":"Smart injectable hydrogels for periodontal regeneration: recent advancements in biomaterials and biofabrication strategies","volume":"32","author":"Yin","year":"2025","journal-title":"Mater Today Bio"},{"key":"2026100311413518800_rbag182-B16","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.dental.2024.12.019","article-title":"Guidance on biomaterials for periodontal tissue regeneration: fabrication methods, materials and biological considerations","volume":"41","author":"Fischer","year":"2025","journal-title":"Dent Mater"},{"key":"2026100311413518800_rbag182-B17","doi-asserted-by":"crossref","first-page":"1639170","DOI":"10.3389\/fbioe.2025.1639170","article-title":"Biomimetic materials: a promising strategy for periodontal tissue engineering and regeneration","volume":"13","author":"Zhang","year":"2025","journal-title":"Front Bioeng Biotechnol"},{"key":"2026100311413518800_rbag182-B18","doi-asserted-by":"crossref","first-page":"e2308848","DOI":"10.1002\/advs.202308848","article-title":"From basic science to clinical practice: a review of current periodontal\/mucogingival regenerative biomaterials","volume":"11","author":"De Lauretis","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"2026100311413518800_rbag182-B19","doi-asserted-by":"crossref","first-page":"101863","DOI":"10.1016\/j.mtbio.2025.101863","article-title":"Regulating periodontal disease with smart stimuli-responsive systems: antimicrobial activity, immunomodulation, periodontium regeneration","volume":"32","author":"Su","year":"2025","journal-title":"Mater Today Bio"},{"key":"2026100311413518800_rbag182-B20","doi-asserted-by":"crossref","first-page":"e70029","DOI":"10.1002\/cre2.70029","article-title":"Thermosensitive hydrogels for periodontal regeneration: a systematic review of the evidence","volume":"10","author":"Amiri","year":"2024","journal-title":"Clin Exp Dent Res"},{"key":"2026100311413518800_rbag182-B21","doi-asserted-by":"crossref","first-page":"1814823","DOI":"10.3389\/froh.2026.1814823","article-title":"Oxidative stress and antioxidant pathways in the pathogenesis of periodontitis and peri-implantitis: mechanistic insights and therapeutic potentials","volume":"7","author":"Hashim","year":"2026","journal-title":"Front Oral Health"},{"key":"2026100311413518800_rbag182-B22","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1039\/D3TB02898D","article-title":"A whole-course-repair system based on ROS\/glucose stimuli-responsive EGCG release and tunable mechanical property for efficient treatment of chronic periodontitis in diabetic rats","volume":"12","author":"Feng","year":"2024","journal-title":"J Mater Chem B"},{"key":"2026100311413518800_rbag182-B23","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s12951-025-03275-4","article-title":"Injectable hydrogels with ROS-triggered drug release enable the co-delivery of antibacterial agent and anti-inflammatory nanoparticle for periodontitis treatment","volume":"23","author":"Zhu","year":"2025","journal-title":"J Nanobiotechnology"},{"key":"2026100311413518800_rbag182-B24","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1186\/s12951-025-03698-z","article-title":"Injectable responsive hydrogel with synergistic antibacterial and anti-inflammatory properties for enhanced periodontitis treatment","volume":"23","author":"Li","year":"2025","journal-title":"J Nanobiotechnology"},{"key":"2026100311413518800_rbag182-B25","doi-asserted-by":"crossref","first-page":"e06438","DOI":"10.1002\/advs.202506438","article-title":"CGRP-loaded ROS-responsive hydrogel restores neuro-angiogenic signaling to promote bone regeneration in diabetes-associated periodontitis","volume":"12","author":"Zhan","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"2026100311413518800_rbag182-B26","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41392-024-01852-x","article-title":"Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions","volume":"9","author":"Lu","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"2026100311413518800_rbag182-B27","doi-asserted-by":"crossref","first-page":"5270","DOI":"10.1021\/acs.biomac.1c01180","article-title":"Redox-responsive hydrogels with decoupled initial stiffness and degradation","volume":"22","author":"Lin","year":"2021","journal-title":"Biomacromolecules"},{"key":"2026100311413518800_rbag182-B28","doi-asserted-by":"crossref","first-page":"e2305756","DOI":"10.1002\/advs.202305756","article-title":"Programmable electro-assembly of collagen: constructing porous Janus films with customized dual signals for immunomodulation and tissue regeneration in periodontitis treatment","volume":"11","author":"Lei","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"2026100311413518800_rbag182-B29","doi-asserted-by":"crossref","first-page":"e2402137","DOI":"10.1002\/adhm.202402137","article-title":"Synthetic periodontal guided tissue regeneration membrane with self-assembling biphasic structure and temperature-sensitive shape maintenance","volume":"14","author":"Swanson","year":"2025","journal-title":"Adv Healthc Mater"},{"key":"2026100311413518800_rbag182-B30","doi-asserted-by":"crossref","first-page":"114443","DOI":"10.1016\/j.mtcomm.2025.114443","article-title":"Smart Polymer-Based membranes for biomedical applications: mechanisms, fabrication, and advances in controlled drug delivery and tissue engineering","volume":"50","author":"Karim Zadeh Bajgiran","year":"2025","journal-title":"Mater Today Commun"},{"key":"2026100311413518800_rbag182-B31","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s10856-026-07016-3","article-title":"Application of PLCL as a biodegradable polymer in biomedical engineering","volume":"37","author":"Zhao","year":"2026","journal-title":"J Mater Sci Mater Med"},{"key":"2026100311413518800_rbag182-B32","doi-asserted-by":"crossref","first-page":"2300081","DOI":"10.1002\/mame.202300081","article-title":"Multiphasic membranes\/scaffolds for periodontal guided tissue regeneration","volume":"308","author":"Zhu","year":"2023","journal-title":"Macro Mater & Eng"},{"key":"2026100311413518800_rbag182-B33","doi-asserted-by":"crossref","first-page":"3504","DOI":"10.3390\/ijms22073504","article-title":"Recent progress on biodegradable tissue engineering scaffolds prepared by thermally-induced phase separation (TIPS)","volume":"22","author":"Zeinali","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026100311413518800_rbag182-B34","doi-asserted-by":"crossref","first-page":"107406","DOI":"10.1016\/j.porgcoat.2023.107406","article-title":"Effects of PLGA coating on biological and mechanical behaviors of tissue engineering scaffolds","volume":"176","author":"Maadani","year":"2023","journal-title":"Prog Org Coat"},{"key":"2026100311413518800_rbag182-B35","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.2147\/IJN.S356250","article-title":"Superhydrophilic PLGA-Graft-PVP\/PC nanofiber membranes for the prevention of epidural adhesion","volume":"17","author":"Fan","year":"2022","journal-title":"Int J Nanomedicine"},{"key":"2026100311413518800_rbag182-B36","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3390\/gels11070544","article-title":"A comprehensive review of thermosensitive hydrogels: mechanism, optimization strategies, and applications","volume":"11","author":"Lv","year":"2025","journal-title":"Gels"},{"key":"2026100311413518800_rbag182-B37","doi-asserted-by":"crossref","first-page":"1384326","DOI":"10.3389\/fbioe.2024.1384326","article-title":"Bioactive injectable mucoadhesive thermosensitive natural polymeric hydrogels for oral bone and periodontal regeneration","volume":"12","author":"El-Nablaway","year":"2024","journal-title":"Front Bioeng Biotechnol"},{"key":"2026100311413518800_rbag182-B38","first-page":"619","article-title":"Recent advances on chitosan-based thermosensitive hydrogels for skin wound treatment","volume":"14","author":"Wang","year":"2025","journal-title":"Biology (Basel)"},{"key":"2026100311413518800_rbag182-B39","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3390\/gels12020098","article-title":"Recent advances in smart stimulus-responsive hydrogels for precision drug delivery in tumours","volume":"12","author":"Zuo","year":"2026","journal-title":"Gels"},{"key":"2026100311413518800_rbag182-B40","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3390\/gels12010011","article-title":"Recent advances in injectable hydrogels for biomedical and aesthetic applications: focus on rheological characteristics","volume":"12","author":"Lee","year":"2025","journal-title":"Gels"},{"key":"2026100311413518800_rbag182-B41","doi-asserted-by":"crossref","first-page":"1323554","DOI":"10.3389\/fbioe.2023.1323554","article-title":"Injectable thermosensitive hydrogel loading erythropoietin and FK506 alleviates gingival inflammation and promotes periodontal tissue regeneration","volume":"11","author":"Gu","year":"2023","journal-title":"Front Bioeng Biotechnol"},{"key":"2026100311413518800_rbag182-B42","doi-asserted-by":"crossref","first-page":"102052","DOI":"10.1016\/j.mtchem.2024.102052","article-title":"Thermosensitive composite hydrogel with antibacterial, immunomodulatory, and osteogenic properties promotes periodontal bone regeneration via staged release of doxycycline and proanthocyanidin","volume":"38","author":"Wang","year":"2024","journal-title":"Mater Today Chem"},{"key":"2026100311413518800_rbag182-B43","doi-asserted-by":"crossref","first-page":"14413","DOI":"10.2147\/IJN.S561138","article-title":"Muco-adhesive hydrogels-based exosome delivery for periodontal tissue regeneration and inflammation reduction: a review","volume":"20","author":"Chen","year":"2025","journal-title":"Int J Nanomedicine"},{"key":"2026100311413518800_rbag182-B44","doi-asserted-by":"crossref","first-page":"15167","DOI":"10.1039\/D5TB01852H","article-title":"Intelligent biomaterials for periodontitis and peri-implantitis therapies: stimuli-responsive strategies targeting inflammation and regeneration","volume":"13","author":"Li","year":"2025","journal-title":"J Mater Chem B"},{"key":"2026100311413518800_rbag182-B45","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s43246-025-00983-0","article-title":"Enzyme-responsive biomaterials for biomedical applications","volume":"6","author":"Pi","year":"2025","journal-title":"Commun Mater"},{"key":"2026100311413518800_rbag182-B46","doi-asserted-by":"crossref","first-page":"115573","DOI":"10.1016\/j.matdes.2026.115573","article-title":"MMP-responsive hydrogel: a new approach for tissue repair and regeneration","volume":"263","author":"Sun","year":"2026","journal-title":"Mater & Des"},{"key":"2026100311413518800_rbag182-B47","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.3390\/ijms23084421","article-title":"Enzyme-responsive hydrogels as potential drug delivery systems-state of knowledge and future prospects","volume":"23","author":"Sobczak","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2026100311413518800_rbag182-B48","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s13770-023-00536-x","article-title":"Development of matrix metalloproteinases-mediated extracellular matrix remodeling in regenerative medicine: a mini review","volume":"20","author":"Chen","year":"2023","journal-title":"Tissue Eng Regen Med"},{"key":"2026100311413518800_rbag182-B49","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1021\/acs.biomac.4c00999","article-title":"Bone enzyme-responsive biodegradable poly(propylene fumarate) and polycaprolactone polyphosphoester dendrimer cross-linked via click chemistry for bone tissue engineering","volume":"26","author":"Liu","year":"2025","journal-title":"Biomacromolecules"},{"key":"2026100311413518800_rbag182-B50","doi-asserted-by":"crossref","first-page":"213647","DOI":"10.1016\/j.bioadv.2023.213647","article-title":"Matrix metalloproteinase degradable, in situ photocrosslinked nanocomposite bioinks for bioprinting applications","volume":"154","author":"Zengin","year":"2023","journal-title":"Biomater Adv"},{"key":"2026100311413518800_rbag182-B51","doi-asserted-by":"crossref","first-page":"148456","DOI":"10.1016\/j.ijbiomac.2025.148456","article-title":"Spirulina protein isolate\/carboxymethyl chitosan based emulsion gel with pH\/enzyme-responsive release of curcumin for enhanced infected wound healing","volume":"331","author":"Mao","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"2026100311413518800_rbag182-B52","doi-asserted-by":"crossref","first-page":"e12554","DOI":"10.1002\/adma.202512554","article-title":"Spatiotemporally engineered protein delivery via integrated covalent coupling and pathological triggers for precision microenvironment reprogramming in tissue injury repair","volume":"38","author":"Quan","year":"2026","journal-title":"Adv Mater"},{"key":"2026100311413518800_rbag182-B53","doi-asserted-by":"crossref","first-page":"114685","DOI":"10.1016\/j.colsurfb.2025.114685","article-title":"Near-infrared light-responsive copper-cerium bimetallic oxide nanozyme with antibacterial and antioxidant abilities for periodontitis therapy","volume":"252","author":"Li","year":"2025","journal-title":"Colloids Surf B Biointerfaces"},{"key":"2026100311413518800_rbag182-B54","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.tibtech.2024.10.001","article-title":"Chairside live biotherapeutic hydrogel for comprehensive periodontitis therapy","volume":"43","author":"Li","year":"2025","journal-title":"Trends Biotechnol"},{"key":"2026100311413518800_rbag182-B55","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1039\/C9NR02412C","article-title":"Self-assembled CeVO4\/Ag nanohybrid as photoconversion agents with enhanced solar-driven photocatalysis and NIR-responsive photothermal\/photodynamic synergistic therapy performance","volume":"11","author":"Chang","year":"2019","journal-title":"Nanoscale"},{"key":"2026100311413518800_rbag182-B56","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1007\/s10103-017-2267-x","article-title":"Gold-coated magnetic nanoparticle as a nanotheranostic agent for magnetic resonance imaging and photothermal therapy of cancer","volume":"32","author":"Eyvazzadeh","year":"2017","journal-title":"Lasers Med Sci"},{"key":"2026100311413518800_rbag182-B57","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41413-018-0032-9","article-title":"Advanced smart biomaterials and constructs for hard tissue engineering and regeneration","volume":"6","author":"Zhang","year":"2018","journal-title":"Bone Res"},{"key":"2026100311413518800_rbag182-B58","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.actbio.2019.07.014","article-title":"Bio-instructive materials for musculoskeletal regeneration","volume":"96","author":"Gonzalez-Fernandez","year":"2019","journal-title":"Acta Biomater"},{"key":"2026100311413518800_rbag182-B59","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/s12951-023-01982-4","article-title":"Nanosilicate-functionalized nanofibrous membrane facilitated periodontal regeneration potential by harnessing periodontal ligament cell-mediated osteogenesis and immunomodulation","volume":"21","author":"Xu","year":"2023","journal-title":"J Nanobiotechnology"},{"key":"2026100311413518800_rbag182-B60","first-page":"19","article-title":"Neutrophil polarization and immune regulation: toward Immune-Bioadaptive dental implants","volume":"2","author":"Zhou","year":"2025","journal-title":"Regener Med Dent"},{"key":"2026100311413518800_rbag182-B61","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s40883-022-00279-6","article-title":"Harnessing biomaterials for immunomodulatory-driven tissue engineering","volume":"9","author":"Zhong","year":"2023","journal-title":"Regen Eng Transl Med"},{"key":"2026100311413518800_rbag182-B62","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.3390\/ijms24043158","article-title":"Regulation of the host immune microenvironment in periodontitis and periodontal bone remodeling","volume":"24","author":"Han","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2026100311413518800_rbag182-B63","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1111\/odi.14360","article-title":"The homeostasis and therapeutic applications of innate and adaptive immune cells in periodontitis","volume":"29","author":"Junxian","year":"2023","journal-title":"Oral Dis"},{"key":"2026100311413518800_rbag182-B64","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/s12276-024-01219-w","article-title":"Neutrophils and neutrophil extracellular traps in oral health and disease","volume":"56","author":"Kim","year":"2024","journal-title":"Exp Mol Med"},{"key":"2026100311413518800_rbag182-B65","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/imr.13152","article-title":"Neutrophils in the periodontium: interactions with pathogens and roles in tissue homeostasis and inflammation","volume":"314","author":"Uriarte","year":"2023","journal-title":"Immunol Rev"},{"key":"2026100311413518800_rbag182-B66","doi-asserted-by":"crossref","first-page":"e70263","DOI":"10.1002\/cre2.70263","article-title":"FOXP3+ T Cells-An emerging evidence in periodontitis therapeutics","volume":"11","author":"\u00dcnsal","year":"2025","journal-title":"Clin Exp Dent Res"},{"key":"2026100311413518800_rbag182-B67","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1186\/s12951-024-02592-4","article-title":"A new direction in periodontitis treatment: biomaterial-mediated macrophage immunotherapy","volume":"22","author":"Peng","year":"2024","journal-title":"J Nanobiotechnology"},{"key":"2026100311413518800_rbag182-B68","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1089\/ten.teb.2023.0157","article-title":"Interaction of macrophages with bone healing microenvironment: mechanism and biomaterials","volume":"30","author":"Lu","year":"2024","journal-title":"Tissue Eng Part B Rev"},{"key":"2026100311413518800_rbag182-B69","first-page":"8","article-title":"Topographical regulation of macrophage-mediated osteoimmunomodulation for bone regeneration","volume":"3","author":"Han","year":"2026","journal-title":"Regener Med Dent"},{"key":"2026100311413518800_rbag182-B70","first-page":"457","article-title":"Dual functional properties of a probiotic biofilm-decorated bone substitute to combat infection and promote osteoimmunomodulation","volume":"57","author":"Song","year":"2026","journal-title":"Bioact Mater"},{"key":"2026100311413518800_rbag182-B71","first-page":"11","article-title":"Emerging strategies for Biomaterials-Mediated reprogramming of macrophages in tissue repair and regeneration","volume":"3","author":"Zhang","year":"2026","journal-title":"Regener Med Dent"},{"key":"2026100311413518800_rbag182-B72","doi-asserted-by":"crossref","first-page":"123024","DOI":"10.1016\/j.biomaterials.2024.123024","article-title":"A nucleoside-based supramolecular hydrogel integrating localized self-delivery and immunomodulation for periodontitis treatment","volume":"316","author":"Shuai","year":"2025","journal-title":"Biomaterials"},{"key":"2026100311413518800_rbag182-B73","doi-asserted-by":"crossref","first-page":"15345","DOI":"10.1021\/acsnano.4c14305","article-title":"Engineered macrophage membrane-camouflaged nanodecoys reshape the infectious microenvironment for efficient periodontitis treatment","volume":"19","author":"Lin","year":"2025","journal-title":"ACS Nano"},{"key":"2026100311413518800_rbag182-B74","first-page":"976","article-title":"CpG ODN\/mangiferin dual delivery through calcium alginate hydrogels inhibits Immune-Mediated osteoclastogenesis and promotes alveolar bone regeneration in mice","volume":"12","author":"Gu","year":"2023","journal-title":"Biology (Basel)"},{"key":"2026100311413518800_rbag182-B75","first-page":"239","article-title":"A five-in-one novel MOF-modified injectable hydrogel with thermo-sensitive and adhesive properties for promoting alveolar bone repair in periodontitis: antibacterial, hemostasis, immune reprogramming, pro-osteo-\/angiogenesis and recruitment","volume":"41","author":"Yang","year":"2024","journal-title":"Bioact Mater"},{"key":"2026100311413518800_rbag182-B76","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1021\/acsami.2c18893","article-title":"Periodontal Ligament-Mimetic fibrous scaffolds regulate YAP-Associated fibroblast behaviors and promote regeneration of periodontal defect in relation to the scaffold topography","volume":"15","author":"Kim","year":"2023","journal-title":"ACS Appl Mater Interfaces"},{"key":"2026100311413518800_rbag182-B77","first-page":"346","article-title":"Piezoelectric hydrogel for treatment of periodontitis through bioenergetic activation","volume":"35","author":"Liu","year":"2024","journal-title":"Bioact Mater"},{"key":"2026100311413518800_rbag182-B78","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.actbio.2009.08.024","article-title":"In vitro biocompatibility of poly(vinylidene fluoride-trifluoroethylene)\/barium titanate composite using cultures of human periodontal ligament fibroblasts and keratinocytes","volume":"6","author":"Teixeira","year":"2010","journal-title":"Acta Biomater"},{"key":"2026100311413518800_rbag182-B79","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/s41598-023-50929-0","article-title":"Fabrication and properties evaluation of chitosan\/BaTiO3 composite membranes for the periodontitis treatment","volume":"14","author":"Houshyar","year":"2024","journal-title":"Sci Rep"},{"key":"2026100311413518800_rbag182-B80","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1089\/bioe.2021.0019","article-title":"Enhancement of bone regeneration through the converse piezoelectric effect, a novel approach for applying mechanical stimulation","volume":"3","author":"Carter","year":"2021","journal-title":"Bioelectricity"},{"key":"2026100311413518800_rbag182-B81","first-page":"295","article-title":"An ultrasound-driven PLGA\/Zn-KNN hybrid piezoelectric scaffold with direct and immunoregulatory antibacterial activity for bone infection","volume":"47","author":"Zheng","year":"2025","journal-title":"Bioact Mater"},{"key":"2026100311413518800_rbag182-B82","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.actbio.2017.08.045","article-title":"Highly porous scaffolds of PEDOT: PSS for bone tissue engineering","volume":"62","author":"Guex","year":"2017","journal-title":"Acta Biomater"},{"key":"2026100311413518800_rbag182-B83","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1089\/ten.tec.2014.0338","article-title":"Electrical stimulation using conductive polymer polypyrrole promotes differentiation of human neural stem cells: a biocompatible platform for translational neural tissue engineering","volume":"21","author":"Stewart","year":"2015","journal-title":"Tissue Eng Part C Methods"},{"key":"2026100311413518800_rbag182-B84","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1089\/ten.tea.2012.0111","article-title":"Novel polypyrrole-coated polylactide scaffolds enhance adipose stem cell proliferation and early osteogenic differentiation","volume":"19","author":"Pelto","year":"2013","journal-title":"Tissue Eng Part A"},{"key":"2026100311413518800_rbag182-B85","doi-asserted-by":"crossref","first-page":"122266","DOI":"10.1016\/j.biomaterials.2023.122266","article-title":"A nano-conductive osteogenic hydrogel to locally promote calcium influx for electro-inspired bone defect regeneration","volume":"301","author":"Yu","year":"2023","journal-title":"Biomaterials"},{"key":"2026100311413518800_rbag182-B86","doi-asserted-by":"crossref","first-page":"123768","DOI":"10.1016\/j.biomaterials.2025.123768","article-title":"Hydrogel-based piezoelectric materials and devices for implantable bioelectronics","volume":"327","author":"Choudhury","year":"2026","journal-title":"Biomaterials"},{"key":"2026100311413518800_rbag182-B87","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1021\/acsnano.1c10678","article-title":"Stretchable unsymmetrical piezoelectric BaTiO3 composite hydrogel for triboelectric nanogenerators and multimodal sensors","volume":"16","author":"Wang","year":"2022","journal-title":"ACS Nano"},{"key":"2026100311413518800_rbag182-B88","first-page":"344","article-title":"Multifunctional piezoelectric hydrogels under ultrasound stimulation boost chondrogenesis by recruiting autologous stem cells and activating the Ca2+\/CaM\/CaN signaling pathway","volume":"50","author":"Liu","year":"2025","journal-title":"Bioact Mater"},{"key":"2026100311413518800_rbag182-B89","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1186\/s12951-026-04124-8","article-title":"Ultrasound-activated piezoelectric hydrogel promotes functional muscle repair by orchestrating myogenesis and reinnervation","volume":"24","author":"Lyu","year":"2026","journal-title":"J Nanobiotechnology"},{"key":"2026100311413518800_rbag182-B90","doi-asserted-by":"crossref","first-page":"e2417564","DOI":"10.1002\/adma.202417564","article-title":"From mechanoelectric conversion to tissue regeneration: translational progress in piezoelectric materials","volume":"37","author":"Wang","year":"2025","journal-title":"Adv Mater"},{"key":"2026100311413518800_rbag182-B91","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1039\/D4BM01347F","article-title":"Piezoelectric hydrogels for accelerating healing of diverse wound types","volume":"13","author":"Wei","year":"2025","journal-title":"Biomater Sci"},{"key":"2026100311413518800_rbag182-B92","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.2217\/nnm-2024-0080","article-title":"Piezoelectric nanomaterials: latest applications in biomedicine and challenges in clinical translation","volume":"19","author":"Marino","year":"2024","journal-title":"Nanomedicine (Lond)"},{"key":"2026100311413518800_rbag182-B93","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1002\/adfm.201202780","article-title":"Polymer-based magnetoelectric materials","volume":"23","author":"Martins","year":"2013","journal-title":"Adv Funct Mater"},{"key":"2026100311413518800_rbag182-B94","doi-asserted-by":"crossref","first-page":"100149","DOI":"10.1016\/j.mtbio.2021.100149","article-title":"Magnetoelectric effect: principles and applications in biology and medicine- a review","volume":"12","author":"Kopyl","year":"2021","journal-title":"Mater Today Bio"},{"key":"2026100311413518800_rbag182-B95","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.1039\/D3TB02617E","article-title":"Advances in magnetoelectric composites for promoting bone regeneration: a review","volume":"12","author":"Li","year":"2024","journal-title":"J Mater Chem B"},{"key":"2026100311413518800_rbag182-B96","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1038\/s41467-023-39744-3","article-title":"In situ activation of flexible magnetoelectric membrane enhances bone defect repair","volume":"14","author":"Liu","year":"2023","journal-title":"Nat Commun"},{"key":"2026100311413518800_rbag182-B97","doi-asserted-by":"crossref","first-page":"58054","DOI":"10.1021\/acsami.3c09428","article-title":"Enhanced proliferation and differentiation of human osteoblasts by remotely controlled magnetic-field-induced electric stimulation using flexible substrates","volume":"15","author":"Careta","year":"2023","journal-title":"ACS Appl Mater Interfaces"},{"key":"2026100311413518800_rbag182-B98","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1111\/jre.13139","article-title":"ScRNA-seq links dental fibroblasts heterogeneity with mechanoresponsiveness","volume":"58","author":"Xu","year":"2023","journal-title":"J Periodontal Res"},{"key":"2026100311413518800_rbag182-B99","doi-asserted-by":"crossref","first-page":"e0213081","DOI":"10.1371\/journal.pone.0213081","article-title":"JDP2 and ATF3 deficiencies dampen maladaptive cardiac remodeling and preserve cardiac function","volume":"14","author":"Kalfon","year":"2019","journal-title":"PLoS One"},{"key":"2026100311413518800_rbag182-B100","doi-asserted-by":"crossref","first-page":"4499","DOI":"10.3390\/ijms23094499","article-title":"Scaffold pore curvature influences \u039cSC fate through differential cellular organization and YAP\/TAZ activity","volume":"23","author":"Swanson","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2026100311413518800_rbag182-B101","doi-asserted-by":"crossref","first-page":"e0149967","DOI":"10.1371\/journal.pone.0149967","article-title":"Dynamic mechanical and nanofibrous topological combinatory cues designed for periodontal ligament engineering","volume":"11","author":"Kim","year":"2016","journal-title":"PLoS One"},{"key":"2026100311413518800_rbag182-B102","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.actbio.2023.12.017","article-title":"Rational design of viscoelastic hydrogels for periodontal ligament remodeling and repair","volume":"174","author":"Zhang","year":"2024","journal-title":"Acta Biomater"},{"key":"2026100311413518800_rbag182-B103","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1186\/s12951-022-01488-5","article-title":"Modulated nanowire scaffold for highly efficient differentiation of mesenchymal stem cells","volume":"20","author":"Perez","year":"2022","journal-title":"J Nanobiotechnology"},{"key":"2026100311413518800_rbag182-B104","doi-asserted-by":"crossref","first-page":"5161","DOI":"10.3390\/ma16145161","article-title":"Dynamic hydrogels with viscoelasticity and tunable stiffness for the regulation of cell behavior and fate","volume":"16","author":"Zhang","year":"2023","journal-title":"Materials (Basel)"},{"key":"2026100311413518800_rbag182-B105","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.actbio.2018.07.050","article-title":"Dual release of growth factor from nanocomposite fibrous scaffold promotes vascularisation and bone regeneration in rat critical sized calvarial defect","volume":"78","author":"Kuttappan","year":"2018","journal-title":"Acta Biomater"},{"key":"2026100311413518800_rbag182-B106","doi-asserted-by":"crossref","first-page":"609297","DOI":"10.3389\/fbioe.2020.609297","article-title":"Biomaterials-mediated regulation of macrophage cell fate","volume":"8","author":"Liu","year":"2020","journal-title":"Front Bioeng Biotechnol"},{"key":"2026100311413518800_rbag182-B107","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3390\/cells11020266","article-title":"Scaffold-mediated immunoengineering as innovative strategy for tendon regeneration","volume":"11","author":"Russo","year":"2022","journal-title":"Cells"},{"key":"2026100311413518800_rbag182-B108","doi-asserted-by":"crossref","first-page":"19806","DOI":"10.1039\/D4RA01459F","article-title":"Direction-oriented fiber guiding with a tunable tri-layer-3D scaffold for periodontal regeneration","volume":"14","author":"Abraham","year":"2024","journal-title":"RSC Adv"},{"key":"2026100311413518800_rbag182-B109","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3390\/jfb16030099","article-title":"Spatial platform for periodontal ligament angulation and regeneration: in vivo pilot study","volume":"16","author":"Kim","year":"2025","journal-title":"J Funct Biomater"},{"key":"2026100311413518800_rbag182-B110","doi-asserted-by":"crossref","first-page":"101015","DOI":"10.1016\/j.mtbio.2024.101015","article-title":"Cascaded controlled delivering growth factors to build vascularized and osteogenic microenvironment for bone regeneration","volume":"25","author":"Cao","year":"2024","journal-title":"Mater Today Bio"},{"key":"2026100311413518800_rbag182-B111","doi-asserted-by":"crossref","first-page":"41855","DOI":"10.1021\/acsami.4c06430","article-title":"Infection-Sensitive SPION\/PLGA scaffolds promote periodontal regeneration via antibacterial activity and macrophage-phenotype modulation","volume":"16","author":"Guo","year":"2024","journal-title":"ACS Appl Mater Interfaces"},{"key":"2026100311413518800_rbag182-B112","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.actbio.2022.07.023","article-title":"Fibre-guiding biphasic scaffold for perpendicular periodontal ligament attachment","volume":"150","author":"Staples","year":"2022","journal-title":"Acta Biomater"},{"key":"2026100311413518800_rbag182-B113","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1039\/D4BM01051E","article-title":"Development of a VEGF-activated scaffold with enhanced angiogenic and neurogenic properties for chronic wound healing applications","volume":"13","author":"Palomeque Ch\u00e1vez","year":"2025","journal-title":"Biomater Sci"},{"key":"2026100311413518800_rbag182-B114","doi-asserted-by":"crossref","first-page":"1003677","DOI":"10.3389\/fbioe.2022.1003677","article-title":"Covalent immobilization of VEGF on allogeneic bone through polydopamine coating to improve bone regeneration","volume":"10","author":"Huang","year":"2022","journal-title":"Front Bioeng Biotechnol"},{"key":"2026100311413518800_rbag182-B115","doi-asserted-by":"crossref","first-page":"5560","DOI":"10.1016\/j.biomaterials.2012.04.038","article-title":"A biphasic scaffold design combined with cell sheet technology for simultaneous regeneration of alveolar bone\/periodontal ligament complex","volume":"33","author":"Vaquette","year":"2012","journal-title":"Biomaterials"},{"key":"2026100311413518800_rbag182-B116","doi-asserted-by":"crossref","first-page":"122848","DOI":"10.1016\/j.biomaterials.2024.122848","article-title":"Immunomodulatory hydrogel orchestrates pro-regenerative response of macrophages and angiogenesis for chronic wound healing","volume":"314","author":"Kuan","year":"2025","journal-title":"Biomaterials"},{"key":"2026100311413518800_rbag182-B117","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1186\/s13287-019-1409-4","article-title":"Macrophage polarization in periodontal ligament stem cells enhanced periodontal regeneration","volume":"10","author":"Liu","year":"2019","journal-title":"Stem Cell Res Ther"},{"key":"2026100311413518800_rbag182-B118","first-page":"3288","article-title":"l-cysteine-modified chiral gold nanoparticles promote periodontal tissue regeneration","volume":"6","author":"Zhang","year":"2021","journal-title":"Bioact Mater"},{"key":"2026100311413518800_rbag182-B119","doi-asserted-by":"crossref","first-page":"e18303","DOI":"10.1002\/advs.202518303","article-title":"Sensory nerve-derived CGRP controls osteoclastogenesis by limiting macrophage bioenergetics in bone repair","volume":"13","author":"Liu","year":"2026","journal-title":"Adv Sci (Weinh)"},{"key":"2026100311413518800_rbag182-B120","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1038\/s41596-018-0035-4","article-title":"An experimental murine model to study periodontitis","volume":"13","author":"Marchesan","year":"2018","journal-title":"Nat Protoc"},{"key":"2026100311413518800_rbag182-B121","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.3390\/biomedicines13112839","article-title":"Recent advances in periodontal regenerative medicine: a focus on the role of mechanical stimulation","volume":"13","author":"Grinchevskaia","year":"2025","journal-title":"Biomedicines"},{"key":"2026100311413518800_rbag182-B122","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1021\/acsbiomaterials.0c01078","article-title":"6-Bromoindirubin-3'-oxime promotes osteogenic differentiation of periodontal ligament stem cells and facilitates bone regeneration in a mouse periodontitis model","volume":"7","author":"Shen","year":"2021","journal-title":"ACS Biomater Sci Eng"},{"key":"2026100311413518800_rbag182-B123","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1177\/00220345211005677","article-title":"Delivery of alkaline phosphatase promotes periodontal regeneration in mice","volume":"100","author":"Nagasaki","year":"2021","journal-title":"J Dent Res"},{"key":"2026100311413518800_rbag182-B124","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1089\/ten.tec.2009.0191","article-title":"Fenestration defects in the rabbit jaw: an inadequate model for studying periodontal regeneration","volume":"16","author":"Oortgiesen","year":"2010","journal-title":"Tissue Eng Part C Methods"},{"key":"2026100311413518800_rbag182-B125","doi-asserted-by":"crossref","first-page":"e18047","DOI":"10.1016\/j.heliyon.2023.e18047","article-title":"Determination of critical-sized defect of mandible in a rabbit model: micro-computed tomography, and histological evaluation","volume":"9","author":"Wang","year":"2023","journal-title":"Heliyon"},{"key":"2026100311413518800_rbag182-B126","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/j.1600-051X.2010.01544.x","article-title":"Periodontal wound healing\/regeneration following implantation of recombinant human growth\/differentiation factor-5 in a beta-tricalcium phosphate carrier into one-wall intrabony defects in dogs","volume":"37","author":"Lee","year":"2010","journal-title":"J Clin Periodontol"},{"key":"2026100311413518800_rbag182-B127","doi-asserted-by":"crossref","first-page":"9636897231198296","DOI":"10.1177\/09636897231198296","article-title":"Periodontal tissue regeneration by transplantation of autologous adipose tissue-derived multi-lineage progenitor cells with carbonate apatite","volume":"32","author":"Takedachi","year":"2023","journal-title":"Cell Transplant"},{"key":"2026100311413518800_rbag182-B128","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.1600-051X.2010.01539.x","article-title":"Regenerative effect of basic fibroblast growth factor on periodontal healing in two-wall intrabony defects in dogs","volume":"37","author":"Shirakata","year":"2010","journal-title":"J Clin Periodontol"},{"key":"2026100311413518800_rbag182-B129","doi-asserted-by":"crossref","first-page":"477","DOI":"10.4103\/0366-6999.199834","article-title":"Comparison of different periodontal healing of critical size noncontained and contained intrabony defects in beagles","volume":"130","author":"Zang","year":"2017","journal-title":"Chin Med J (Engl)"},{"key":"2026100311413518800_rbag182-B130","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1111\/j.1600-0765.2012.01475.x","article-title":"Application of collagen hydrogel\/sponge scaffold facilitates periodontal wound healing in class II furcation defects in beagle dogs","volume":"47","author":"Kosen","year":"2012","journal-title":"J Periodontal Res"},{"key":"2026100311413518800_rbag182-B131","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/jcpe.13694","article-title":"Cross-linked hyaluronic acid gel with or without a collagen matrix in the treatment of class III furcation defects: a histologic and histomorphometric study in dogs","volume":"49","author":"Shirakata","year":"2022","journal-title":"J Clin Periodontol"},{"key":"2026100311413518800_rbag182-B132","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1177\/00220345010800121001","article-title":"Periodontal regeneration by FGF-2 (bFGF) in primate models","volume":"80","author":"Takayama","year":"2001","journal-title":"J Dent Res"},{"key":"2026100311413518800_rbag182-B133","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41368-018-0020-3","article-title":"Local icariin application enhanced periodontal tissue regeneration and relieved local inflammation in a minipig model of periodontitis","volume":"10","author":"Zhang","year":"2018","journal-title":"Int J Oral Sci"},{"key":"2026100311413518800_rbag182-B134","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s13287-016-0362-8","article-title":"Periodontal regeneration in swine after cell injection and cell sheet transplantation of human dental pulp stem cells following good manufacturing practice","volume":"7","author":"Hu","year":"2016","journal-title":"Stem Cell Res Ther"},{"key":"2026100311413518800_rbag182-B135","first-page":"3960798","article-title":"Local injection of allogeneic stem cells from apical papilla enhanced periodontal tissue regeneration in minipig model of periodontitis","volume":"2018","author":"Li","year":"2018","journal-title":"Biomed Res Int"},{"key":"2026100311413518800_rbag182-B136","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1177\/00220345211028852","article-title":"Successful application of a galanin-coated scaffold for periodontal regeneration","volume":"100","author":"Ma","year":"2021","journal-title":"J Dent Res"},{"key":"2026100311413518800_rbag182-B137","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1177\/0022034511423665","article-title":"Regeneration of periodontal tissues in non-human primates with rhGDF-5 and beta-tricalcium phosphate","volume":"90","author":"Emerton","year":"2011","journal-title":"J Dent Res"},{"key":"2026100311413518800_rbag182-B138","volume-title":"Animal Models for Oral and Craniofacial Research","author":"Giannobile","year":"2019","edition":"2nd edn"},{"key":"2026100311413518800_rbag182-B139","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1177\/0022034509349748","article-title":"Pre-clinical models for oral and periodontal reconstructive therapies","volume":"88","author":"Pellegrini","year":"2009","journal-title":"J Dent Res"},{"key":"2026100311413518800_rbag182-B140","first-page":"142","article-title":"Animal models for testing biomaterials in periodontal regeneration","volume":"4","author":"Sun","year":"2023","journal-title":"Biomater Transl"},{"key":"2026100311413518800_rbag182-B141","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/prd.12052","article-title":"Animal models for periodontal regeneration and peri-implant responses","volume":"68","author":"Kantarci","year":"2015","journal-title":"Periodontol 2000"},{"key":"2026100311413518800_rbag182-B142","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3390\/gels9070573","article-title":"Evaluation of osteogenic potential of fucoidan containing chitosan hydrogel in the treatment of periodontal intra-bony defects-A randomized clinical trial","volume":"9","author":"Eshwar","year":"2023","journal-title":"Gels"},{"key":"2026100311413518800_rbag182-B143","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1111\/jre.13310","article-title":"Recombinant human fibroblast growth factor and autogenous bone for periodontal regeneration: alone or in combination? A randomized clinical trial","volume":"59","author":"Kojima","year":"2024","journal-title":"J Periodontal Res"},{"key":"2026100311413518800_rbag182-B144","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1177\/0022034510384616","article-title":"FGF-2 stimulates periodontal regeneration: results of a multi-center randomized clinical trial","volume":"90","author":"Kitamura","year":"2011","journal-title":"J Dent Res"},{"key":"2026100311413518800_rbag182-B145","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1177\/0022034516632497","article-title":"A randomized clinical trial evaluating rh-FGF-2\/\u03b2-TCP in periodontal defects","volume":"95","author":"Cochran","year":"2016","journal-title":"J Dent Res"},{"key":"2026100311413518800_rbag182-B146","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/jcpe.12406","article-title":"Human intrabony defect regeneration with rhFGF-2 and hyaluronic acid - a randomized controlled clinical trial","volume":"42","author":"de Santana","year":"2015","journal-title":"J Clin Periodontol"},{"key":"2026100311413518800_rbag182-B147","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/jcpe.13086","article-title":"Treatment of intrabony periodontal defects using rhFGF-2 in combination with deproteinized bovine bone mineral or rhFGF-2 alone: a 6-month randomized controlled trial","volume":"46","author":"Saito","year":"2019","journal-title":"J Clin Periodontol"},{"key":"2026100311413518800_rbag182-B148","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1902\/jop.2005.76.12.2205","article-title":"Platelet-derived growth factor stimulates bone fill and rate of attachment level gain: results of a large multicenter randomized controlled trial","volume":"76","author":"Nevins","year":"2005","journal-title":"J Periodontol"},{"key":"2026100311413518800_rbag182-B149","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1902\/jop.2003.74.9.1282","article-title":"Periodontal regeneration in humans using recombinant human platelet-derived growth factor-BB (rhPDGF-BB) and allogenic bone","volume":"74","author":"Nevins","year":"2003","journal-title":"J Periodontol"},{"key":"2026100311413518800_rbag182-B150","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/jre.70060","article-title":"Adjunctive therapies in periodontitis: current concepts and the future","volume":"61","author":"de Molon","year":"2026","journal-title":"J Periodontal Res"},{"key":"2026100311413518800_rbag182-B151","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s40824-022-00315-0","article-title":"Modularized bioceramic scaffold\/hydrogel membrane hierarchical architecture beneficial for periodontal tissue regeneration in dogs","volume":"26","author":"Wei","year":"2022","journal-title":"Biomater Res"},{"key":"2026100311413518800_rbag182-B152","doi-asserted-by":"crossref","first-page":"1223339","DOI":"10.3389\/fbioe.2023.1223339","article-title":"Titanium surfaces with biomimetic topography and copper incorporation to modulate behaviors of stem cells and oral bacteria","volume":"11","author":"Li","year":"2023","journal-title":"Front Bioeng Biotechnol"},{"key":"2026100311413518800_rbag182-B153","doi-asserted-by":"crossref","first-page":"16686","DOI":"10.3390\/ijms242316686","article-title":"Influence of topography and composition of commercial titanium dental implants on cell adhesion of human gingiva-derived mesenchymal stem cells: an in vitro study","volume":"24","author":"Campos-Bijit","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2026100311413518800_rbag182-B154","doi-asserted-by":"crossref","first-page":"27703","DOI":"10.1021\/acsami.2c06679","article-title":"Titanium nanosurface with a biomimetic physical microenvironment to induce endogenous regeneration of the periodontium","volume":"14","author":"Yamada","year":"2022","journal-title":"ACS Appl Mater Interfaces"},{"key":"2026100311413518800_rbag182-B155","doi-asserted-by":"crossref","first-page":"145443","DOI":"10.1016\/j.ijbiomac.2025.145443","article-title":"Collagen-enhanced piezoelectric PLLA\/ZnO microfiber barrier membranes for superior bone regeneration","volume":"319","author":"Zhou","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"2026100311413518800_rbag182-B156","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1039\/D1TB02068D","article-title":"A bioinspired Janus polyurethane membrane for potential periodontal tissue regeneration","volume":"10","author":"He","year":"2022","journal-title":"J Mater Chem B"},{"key":"2026100311413518800_rbag182-B157","first-page":"4","article-title":"Cell secretome from mesenchymal stem cells for periodontal regeneration","volume":"1","author":"Chen","year":"2024","journal-title":"Regener Med Dent"},{"key":"2026100311413518800_rbag182-B158","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3390\/medicina61010020","article-title":"Challenges and innovations in alveolar bone regeneration: a narrative review on materials, techniques, clinical outcomes, and future directions","volume":"61","author":"Marian","year":"2024","journal-title":"Medicina (Kaunas)"},{"key":"2026100311413518800_rbag182-B159","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.2174\/0113816128341715241216060613","article-title":"Recent advances in 4D printing: a review of current smart materials, technologies, and drug delivery systems","volume":"31","author":"Parhi","year":"2025","journal-title":"Curr Pharm Des"},{"key":"2026100311413518800_rbag182-B160","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.1080\/09205063.2025.2509031","article-title":"An overview of recent advancements in 4D printing of alginate hydrogels for tissue regeneration","volume":"36","author":"Liu","year":"2025","journal-title":"J Biomater Sci Polym Ed"},{"key":"2026100311413518800_rbag182-B161","doi-asserted-by":"crossref","first-page":"6005","DOI":"10.1039\/D3TB03070A","article-title":"Recent advances in injectable hydrogel therapies for periodontitis","volume":"12","author":"Ran","year":"2024","journal-title":"J Mater Chem B"},{"key":"2026100311413518800_rbag182-B162","doi-asserted-by":"crossref","first-page":"630488","DOI":"10.3389\/fbioe.2021.630488","article-title":"Bioink formulations for bone tissue regeneration","volume":"9","author":"Li","year":"2021","journal-title":"Front Bioeng Biotechnol"},{"key":"2026100311413518800_rbag182-B163","doi-asserted-by":"crossref","first-page":"114688","DOI":"10.1016\/j.biopha.2023.114688","article-title":"Smart stimuli-responsive hydrogels for drug delivery in periodontitis treatment","volume":"162","author":"Wang","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"2026100311413518800_rbag182-B164","doi-asserted-by":"crossref","first-page":"143205","DOI":"10.1016\/j.ijbiomac.2025.143205","article-title":"Injectable CuS-loaded carboxymethyl and sulfonated chitosan hydrogel with antibacterial and self-healing properties promoting periodontal tissue regeneration","volume":"310","author":"Wang","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"2026100311413518800_rbag182-B165","doi-asserted-by":"crossref","first-page":"142080","DOI":"10.1016\/j.ijbiomac.2025.142080","article-title":"Chitosan-P407-PNIPAM hydrogel loaded with AgNPs\/lipid complex for antibacterial, inflammation regulation and alveolar bone regeneration in periodontitis treatment","volume":"307","author":"Zhang","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"2026100311413518800_rbag182-B166","doi-asserted-by":"crossref","first-page":"6590","DOI":"10.3390\/app14156590","article-title":"Artificial intelligence in biomaterials: a comprehensive review","volume":"14","author":"Gokcekuyu","year":"2024","journal-title":"Appl Sci [Internet]"},{"key":"2026100311413518800_rbag182-B167","doi-asserted-by":"crossref","first-page":"e70016","DOI":"10.1111\/srt.70016","article-title":"Recent advances in artificial intelligent strategies for tissue engineering and regenerative medicine","volume":"30","author":"Gharibshahian","year":"2024","journal-title":"Skin Res Technol"},{"key":"2026100311413518800_rbag182-B168","doi-asserted-by":"crossref","first-page":"e70004","DOI":"10.1002\/bmm2.70004","article-title":"Artificial intelligence-assisted design, synthesis and analysis of smart biomaterials","volume":"3","author":"Jiang","year":"2025","journal-title":"BMEmat"},{"key":"2026100311413518800_rbag182-B169","doi-asserted-by":"crossref","first-page":"21222","DOI":"10.1007\/s10853-024-10449-2","article-title":"Review on machine learning application in tissue engineering: what has been done so far? Application areas, challenges, and perspectives","volume":"59","author":"Jeznach","year":"2024","journal-title":"J Mater Sci"},{"key":"2026100311413518800_rbag182-B170","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.3390\/microorganisms12091797","article-title":"Oral microbiome: a review of its impact on oral and systemic health","volume":"12","author":"Rajasekaran","year":"2024","journal-title":"Microorganisms"},{"key":"2026100311413518800_rbag182-B171","doi-asserted-by":"crossref","first-page":"1288722","DOI":"10.3389\/froh.2023.1288722","article-title":"Immunomodulation of periodontitis with SPMs","volume":"4","author":"Sahni","year":"2023","journal-title":"Front Oral Health"},{"key":"2026100311413518800_rbag182-B172","doi-asserted-by":"crossref","first-page":"1081977","DOI":"10.3389\/fbioe.2022.1081977","article-title":"Robust intervention for oxidative stress-induced injury in periodontitis via controllably released nanoparticles that regulate the ROS-PINK1-Parkin pathway","volume":"10","author":"Li","year":"2022","journal-title":"Front Bioeng Biotechnol"},{"key":"2026100311413518800_rbag182-B173","doi-asserted-by":"crossref","first-page":"5790","DOI":"10.3390\/ijms24065790","article-title":"The applications and potentials of extracellular vesicles from different cell sources in periodontal regeneration","volume":"24","author":"Huang","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2026100311413518800_rbag182-B174","doi-asserted-by":"crossref","first-page":"673","DOI":"10.3390\/biom13040673","article-title":"Advances focusing on the application of decellularized extracellular matrix in periodontal regeneration","volume":"13","author":"Liang","year":"2023","journal-title":"Biomolecules"},{"key":"2026100311413518800_rbag182-B175","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.3390\/antiox12091787","article-title":"Influence of reactive oxygen species on wound healing and tissue regeneration in periodontal and peri-implant tissues in diabetic patients","volume":"12","author":"Buranasin","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"2026100311413518800_rbag182-B176","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s00774-026-01706-2","article-title":"Inflammaging in periodontal, periapical, and malignancy-associated disease: drivers of alveolar bone loss and repair","volume":"44","author":"Surboyo","year":"2026","journal-title":"J Bone Miner Metab"}],"container-title":["Regenerative Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/rb\/advance-article-pdf\/doi\/10.1093\/rb\/rbag182\/70724609\/rbag182.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/rb\/article-pdf\/doi\/10.1093\/rb\/rbag182\/70724609\/rbag182.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/rb\/article-pdf\/doi\/10.1093\/rb\/rbag182\/70724609\/rbag182.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:42:26Z","timestamp":1791042146000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/rb\/article\/doi\/10.1093\/rb\/rbag182\/8767174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":176,"URL":"https:\/\/doi.org\/10.1093\/rb\/rbag182","relation":{},"ISSN":["2056-3418","2056-3426"],"issn-type":[{"value":"2056-3418","type":"print"},{"value":"2056-3426","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"rbag182"}}