{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:39:40Z","timestamp":1792013980149,"version":"4.4.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51473164"],"award-info":[{"award-number":["51473164"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51673186"],"award-info":[{"award-number":["51673186"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chinese Academy of Sciences and Japan Society for the Promotion of Science","award":["GJHZ1519"],"award-info":[{"award-number":["GJHZ1519"]}]},{"name":"Special Fund for Industrialization of Science and Technology Cooperation between Jilin Province and Chinese Academy of Sciences","award":["2017SYHZ0021"],"award-info":[{"award-number":["2017SYHZ0021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Reusable microcarriers with appropriate surface topography, mechanical properties, as well as biological modification through decellularization facilitating repeated cell culture are crucial for tissue engineering applications. Herein, we report the preparation of topological polyetheretherketone (PEEK) microcarriers via gas-driven and solvent exchange method followed by hydrothermal treatment at high temperature and pressure. After hydrothermal treated for 8\u2009h, the resulting topological PEEK microcarriers exhibit walnut-like surface topography and good sphericity as well as uniform size distribution of 350.24\u2009\u00b1\u200919.44\u2009\u00b5m. And the average width between ravine-patterned surface of PEEK microcarriers is 780\u2009\u00b1\u2009290\u2009nm. After repeated steam sterilization by autoclaving for three times, topological PEEK microcarriers show nearly identical results compared with previous ones indicating strong tolerance to high temperature and pressure. This is a unique advantage for large-scale cell expansion and clinical applications. Moreover, PEEK microcarriers with special topography possess higher protein adsorption efficiency. In addition, the reutilization and biofunctionalization with repeated decellularization of topological PEEK microcarriers show highly beneficial for cell adhesion and proliferation. Therefore, our study is of great importance for new generation microcarriers with micro-and nano-scale surface feature for a broad application prospect in tissue engineering.<\/jats:p>","DOI":"10.1093\/rb\/rbz032","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T03:23:25Z","timestamp":1569900205000},"source":"Crossref","is-referenced-by-count":3,"title":["Biomimetic polyetheretherketone microcarriers with specific surface topography and self-secreted extracellular matrix for large-scale cell expansion"],"prefix":"10.1093","author":[{"given":"Qingming","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Spine Surgery, The First Hospital of Jilin University, Changchun, PR China"},{"name":"Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, PR 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Changchun, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, The First Hospital of Jilin University, Changchun, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peibiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,9,30]]},"reference":[{"key":"2019093009315440800_rbz032-B1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1741-7015-9-52","article-title":"Clinical trials for stem cell therapies","volume":"9","author":"Trounson","year":"2011","journal-title":"BMC Med"},{"key":"2019093009315440800_rbz032-B2","first-page":"S014296121730755X","article-title":"Strategies for MSC 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