{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:31:58Z","timestamp":1792794718776,"version":"4.5.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institute of Health Research","doi-asserted-by":"crossref","award":["180509"],"award-info":[{"award-number":["180509"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institute of Health Research","doi-asserted-by":"crossref","award":["177939"],"award-info":[{"award-number":["177939"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Recruitment Scholarship from the R\u00e9seau en reproduction du Qu\u00e9bec"},{"DOI":"10.13039\/100030922","name":"Research Institute of the McGill University Health Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030922","id-type":"DOI","asserted-by":"publisher"}]},{"name":"RI-MUHC Desjardins Studentship"},{"name":"Faculty of Medicine and Health Sciences of McGill University"},{"name":"Milne Research Award from Victoria College at the University of Toronto","id":[{"id":"https:\/\/ror.org\/03dbr7087","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Helicase for meiosis 1 (HFM1) is an ATP-dependent DNA helicase expressed primarily in the germ cells and plays a conserved role in meiotic synapsis and recombination. Biallelic HFM1 mutations are responsible for female infertility and various forms of pregnancy loss associated with primary ovarian insufficiency (POI), whereas monoallelic HFM1 mutations are found in women with milder forms of reproductive failures. Homozygous null mutation of Hfm1 in the female mouse exhibited severe defects in the meiotic synapsis and crossovers in oocytes, leading to aberrant chromosome segregation at the first meiotic division. However, the Hfm1 null female mouse loses all its oocytes prior to puberty, precluding further studies on the role of HFM1 in female reproduction. In the current study, we examined various fertility parameters in the heterozygous Hfm1 mutant mouse, which did not exhibit aberrant meiotic synapsis or recombination. Our results indicated largely normal ovarian development, consistent with their fertility. Nonetheless, we found (1) mild defects in follicle formation and recruitment, (2) delay in the initial increase in reproductive capacity and faster decline in fertility with age, (3) slower preimplantation development of embryos in culture, and (4) smaller ovarian reserve near the end of the reproductive life, compared to wild-type mice. We suggest that similar defects may underlie the reproductive failure of women with monoallelic HFM1 mutations.<\/jats:p>","DOI":"10.1093\/reprod\/xaaf023","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T12:23:42Z","timestamp":1767615822000},"source":"Crossref","is-referenced-by-count":1,"title":["Mild defects in follicular development and reproductive performance in the heterozygous\n                    <i>Hfm1<\/i>\n                    female mouse"],"prefix":"10.1093","volume":"171","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6029-4038","authenticated-orcid":false,"given":"Lavi","family":"Bhati","sequence":"first","affiliation":[{"name":"Department of Human Genetics, McGill University Health Centre , Montr\u00e9al, Qu\u00e9bec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3705-5633","authenticated-orcid":false,"given":"Adriana C","family":"Ene","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, McGill University Health Centre , Montr\u00e9al, Qu\u00e9bec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3875-5043","authenticated-orcid":false,"given":"Jessy","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, McGill University Health Centre , Montr\u00e9al, Qu\u00e9bec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6118-7425","authenticated-orcid":false,"given":"Manqi","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, McGill University Health Centre , Montr\u00e9al, Qu\u00e9bec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8723-793X","authenticated-orcid":false,"given":"Parinaz","family":"Kazemi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, McGill University Health Centre , Montr\u00e9al, Qu\u00e9bec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0876-5150","authenticated-orcid":false,"given":"Jacinta H","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, McGill University Health Centre , Montr\u00e9al, Qu\u00e9bec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4060-2159","authenticated-orcid":false,"given":"Rima","family":"Slim","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, McGill University Health Centre , Montr\u00e9al, Qu\u00e9bec,","place":["Canada"]},{"name":"Department of Obstetrics and Gynecology, McGill University Health Centre , Montr\u00e9al, Qu\u00e9bec,","place":["Canada"]},{"name":"Department of Surgery, McGill University Health Centre , Montr\u00e9al, Qu\u00e9bec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7077-3768","authenticated-orcid":false,"given":"Teruko","family":"Taketo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, McGill University Health Centre , Montr\u00e9al, Qu\u00e9bec,","place":["Canada"]},{"name":"Department of Surgery, McGill University Health Centre , Montr\u00e9al, Qu\u00e9bec,","place":["Canada"]},{"name":"Research Institute of McGill University Health Centre , Montr\u00e9al, 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