{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T21:06:53Z","timestamp":1784322413782,"version":"3.55.0"},"reference-count":83,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC2706800"],"award-info":[{"award-number":["2024YFC2706800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301869"],"award-info":[{"award-number":["82301869"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271687"],"award-info":[{"award-number":["82271687"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274651"],"award-info":[{"award-number":["82274651"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Granulosa cells play a pivotal role in follicle initiation and development. Metabolic disorders can inflict damage on granulosa cells, ultimately leading to abnormal ovarian function. It is well established that a high dietary intake of fructose can induce a range of metabolic diseases, such as insulin resistance and non-alcoholic fatty liver disease. However, the underlying mechanism by which fructose affects ovarian function remains unclear. In this study, we subjected wild-type mice to a 30% fructose solution in their drinking water for 16\u2009weeks to establish high-fructose animal models. The results obtained showed that in mice exposed to high fructose, hormone levels and estrous cycles were abnormal, and the number of atretic follicles increased. Simultaneously, senescence and apoptosis of granulosa cells were also observed in high-fructose mice, and the level of cellular protein O-GlcNAcylation significantly increased. Treatment of granulosa cells with the O-GlcNAcylation activator Thiamet G and inhibitor OSMI-1 demonstrated that elevated O-GlcNAcylation induces granulosa cell senescence and promotes apoptosis. We utilized immunoprecipitation-mass spectrometry to investigate O-GlcNAcylated proteins in the ovaries of high-fructose mice and the results indicated that numerous proteins had significantly elevated O-GlcNAcylation levels, mainly centered on the chromatin \u201cremodeling\u201d and \u201cnucleocytoplasmic transport\u201d pathways. Among them, increases in the O-GlcNAcylation levels of nucleoporin 54 and glucose-regulated protein 78 were confirmed by co-immunopreciptitation. These results uncover a new mechanism of fructose-induced ovarian function impairment, providing potential targets for the treatment of diet-related fertility disorders.<\/jats:p>","DOI":"10.1093\/reprod\/xaag005","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T12:45:25Z","timestamp":1768394725000},"source":"Crossref","is-referenced-by-count":0,"title":["High dietary fructose induces the senescence of granulosa cells by enhancing O-GlcNAcylation"],"prefix":"10.1093","volume":"171","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1654-8986","authenticated-orcid":false,"given":"Rui","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing, Jiangsu,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing, Jiangsu,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing, Jiangsu,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing, Jiangsu,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine, Nanjing Medical University , Nanjing, Jiangsu,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine, Nanjing Medical University , Nanjing, Jiangsu,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjie","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing, Jiangsu,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing, Jiangsu,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing, Jiangsu,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing, Jiangsu,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rujun","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing, Jiangsu,","place":["China"]},{"name":"Department of Reproductive Medicine, Jinling Clinical Medical College, Nanjing University of Chinese Medicine , Nanjing, Jiangsu,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3420-2220","authenticated-orcid":false,"given":"Bing","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing, Jiangsu,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"2026071717020451400_xaag005-B1","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1210\/edrv-6-3-400","article-title":"Insulin-like growth factors as intraovarian regulators of granulosa cell growth and function","volume":"6","author":"Adashi","year":"1985","journal-title":"Endocrine Reviews"},{"key":"2026071717020451400_xaag005-B2","doi-asserted-by":"crossref","first-page":"4110","DOI":"10.3390\/ijms23084110","article-title":"Controversies in the pathogenesis, diagnosis and treatment of PCOS: Focus on insulin resistance, inflammation, and hyperandrogenism","volume":"23","author":"Armanini","year":"2022","journal-title":"International Journal of Molecular Sciences"},{"key":"2026071717020451400_xaag005-B3","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.tice.2019.07.001","article-title":"Azoramide ameliorates fructose-induced nonalcoholic fatty liver disease in mice","volume":"59","author":"Bagci","year":"2019","journal-title":"Tissue & Cell"},{"key":"2026071717020451400_xaag005-B4","doi-asserted-by":"crossref","first-page":"e35538","DOI":"10.1371\/journal.pone.0035538","article-title":"Mouse estrous cycle identification tool and images","volume":"7","author":"Byers","year":"2012","journal-title":"PLoS One"},{"key":"2026071717020451400_xaag005-B5","doi-asserted-by":"crossref","first-page":"114015","DOI":"10.1016\/j.ygcen.2022.114015","article-title":"HucMSCs-exosomes containing miR-21 promoted estrogen production in ovarian granulosa cells via LATS1-mediated phosphorylation of LOXL2 and YAP","volume":"321\u2013322","author":"Cai","year":"2022","journal-title":"General and Comparative Endocrinology"},{"key":"2026071717020451400_xaag005-B6","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1093\/gerona\/gln073","article-title":"How does proliferative homeostasis change with age? What causes it and how does it contribute to aging?","volume":"64","author":"Campisi","year":"2009","journal-title":"The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences"},{"key":"2026071717020451400_xaag005-B7","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2174\/1389450116666150202155915","article-title":"Roles of apoptosis and cellular senescence in cancer and aging","volume":"17","author":"Cerella","year":"2016","journal-title":"Current Drug Targets"},{"key":"2026071717020451400_xaag005-B8","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1038\/s41380-025-02943-z","article-title":"Brain O-GlcNAcylation: Bridging physiological functions, disease mechanisms, and therapeutic applications","volume":"30","author":"Chen","year":"2025","journal-title":"Molecular Psychiatry"},{"key":"2026071717020451400_xaag005-B9","doi-asserted-by":"crossref","first-page":"e2422749","DOI":"10.1001\/jamanetworkopen.2024.22749","article-title":"Essential nutrients, added sugar intake, and epigenetic age in midlife black and white women: NIMHD social epigenomics program","volume":"7","author":"Chiu","year":"2024","journal-title":"JAMA Network Open"},{"key":"2026071717020451400_xaag005-B10","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.2174\/1389557519666190410125910","article-title":"Recent advances in apoptosis: The role of hydrazones","volume":"19","author":"\u00c7\u0131kla-S\u00fczg\u00fcn","year":"2019","journal-title":"Mini Reviews in Medicinal Chemistry"},{"key":"2026071717020451400_xaag005-B11","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1126\/science.adj7050","article-title":"Cellular senescence in normal physiology","volume":"384","author":"de Magalh\u00e3es","year":"2024","journal-title":"Science (New York, N.Y.)"},{"key":"2026071717020451400_xaag005-B12","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s12974-023-02824-8","article-title":"Ogt-mediated O-GlcNAcylation inhibits astrocytes activation through modulating NF-\u03baB signaling pathway","volume":"20","author":"Dong","year":"2023","journal-title":"Journal of Neuroinflammation"},{"key":"2026071717020451400_xaag005-B13","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicologic Pathology"},{"key":"2026071717020451400_xaag005-B14","doi-asserted-by":"crossref","DOI":"10.3390\/nu17010124","article-title":"Fructose-induced metabolic dysfunction is dependent on the baseline diet, the length of the dietary exposure, and sex of the mice","volume":"17,","author":"Fadhul","year":"2024","journal-title":"Nutrients"},{"key":"2026071717020451400_xaag005-B15","doi-asserted-by":"crossref","first-page":"33","DOI":"10.33549\/physiolres.934233","article-title":"Metabolic cooperation in the ovarian follicle","volume":"69","author":"Fontana","year":"2020","journal-title":"Physiological Research"},{"key":"2026071717020451400_xaag005-B16","doi-asserted-by":"crossref","first-page":"617225","DOI":"10.3389\/fcell.2021.617225","article-title":"Telomere dysfunction in oocytes and embryos from obese mice","volume":"9","author":"Ge","year":"2021","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"2026071717020451400_xaag005-B17","doi-asserted-by":"crossref","first-page":"25166","DOI":"10.1074\/jbc.M114.589341","article-title":"Binding of tissue-type plasminogen activator to the glucose-regulated protein 78 (GRP78) modulates plasminogen activation and promotes human neuroblastoma cell proliferation in vitro","volume":"289","author":"Gonzalez-Gronow","year":"2014","journal-title":"The Journal of Biological Chemistry"},{"key":"2026071717020451400_xaag005-B18","doi-asserted-by":"crossref","first-page":"R67","DOI":"10.1530\/RAF-21-0014","article-title":"Pathophysiology and management of classic galactosemic primary ovarian insufficiency","volume":"2","author":"Hagen-Lillevik","year":"2021","journal-title":"Reproduction & Fertility"},{"key":"2026071717020451400_xaag005-B19","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1146\/annurev-biophys-052118-115308","article-title":"Structure and assembly of the nuclear pore complex","volume":"48","author":"Hampoelz","year":"2019","journal-title":"Annual Review of Biophysics"},{"key":"2026071717020451400_xaag005-B20","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1172\/JCI96702","article-title":"Fructose metabolism and metabolic disease","volume":"128","author":"Hannou","year":"2018","journal-title":"The Journal of Clinical Investigation"},{"key":"2026071717020451400_xaag005-B21","doi-asserted-by":"crossref","first-page":"216258","DOI":"10.1016\/j.canlet.2023.216258","article-title":"O-GlcNAcylation in cancer development and immunotherapy","volume":"566","author":"He","year":"2023","journal-title":"Cancer Letters"},{"key":"2026071717020451400_xaag005-B22","doi-asserted-by":"crossref","first-page":"105768","DOI":"10.1016\/j.yrtph.2024.105768","article-title":"Rodent estrous cycle pattern: Harmonizing the cycle evaluation and interpretation","volume":"156","author":"Holalagoudar","year":"2025","journal-title":"Regulatory Toxicology and Pharmacology: RTP"},{"key":"2026071717020451400_xaag005-B23","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.lfs.2019.04.022","article-title":"GRP78: A cell\u2019s response to stress","volume":"226","author":"Ibrahim","year":"2019","journal-title":"Life Sciences"},{"key":"2026071717020451400_xaag005-B24","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1262\/jrd.10-198E","article-title":"Role of cell-death ligand-receptor system of granulosa cells in selective follicular atresia in porcine ovary","volume":"57","author":"Inoue","year":"2011","journal-title":"The Journal of Reproduction and Development"},{"key":"2026071717020451400_xaag005-B25","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.cell.2015.05.013","article-title":"Allosteric regulation in gating the central channel of the nuclear pore complex","volume":"161","author":"Koh","year":"2015","journal-title":"Cell"},{"key":"2026071717020451400_xaag005-B26","doi-asserted-by":"crossref","first-page":"e13270","DOI":"10.1111\/acel.13270","article-title":"On the evolution of cellular senescence","volume":"19","author":"Kowald","year":"2020","journal-title":"Aging Cell"},{"key":"2026071717020451400_xaag005-B27","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1016\/j.cell.2025.03.011","article-title":"From geroscience to precision geromedicine: Understanding and managing aging","volume":"188","author":"Kroemer","year":"2025","journal-title":"Cell"},{"key":"2026071717020451400_xaag005-B28","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.canlet.2016.04.035","article-title":"The phosphorylation-specific association of STMN1 with GRP78 promotes breast cancer metastasis","volume":"377","author":"Kuang","year":"2016","journal-title":"Cancer Letters"},{"key":"2026071717020451400_xaag005-B29","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1038\/s12276-021-00709-5","article-title":"O-GlcNAcylation in health and neurodegenerative diseases","volume":"53","author":"Lee","year":"2021","journal-title":"Experimental & Molecular Medicine"},{"key":"2026071717020451400_xaag005-B30","doi-asserted-by":"crossref","DOI":"10.1530\/REP-24-0138","article-title":"O-GlcNAc participates in the meiosis of aging oocytes by mediating mitochondrial function","volume":"168","author":"Li","year":"2024","journal-title":"Reproduction (Cambridge, England)"},{"key":"2026071717020451400_xaag005-B31","doi-asserted-by":"crossref","first-page":"e2218332120","DOI":"10.1073\/pnas.2218332120","article-title":"OGT controls mammalian cell viability by regulating the proteasome\/mTOR\/mitochondrial axis","volume":"120","author":"Li","year":"2023","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"2026071717020451400_xaag005-B32","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neo.2016.11.007","article-title":"GALNT6 Stabilizes GRP78 protein by o-glycosylation and enhances its activity to suppress apoptosis under stress condition","volume":"19","author":"Lin","year":"2017","journal-title":"Neoplasia (New York, N.Y.)"},{"key":"2026071717020451400_xaag005-B33","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.devcel.2017.08.020","article-title":"Mitotic disassembly of nuclear pore complexes involves CDK1- and PLK1-mediated phosphorylation of key interconnecting nucleoporins","volume":"43","author":"Linder","year":"2017","journal-title":"Developmental Cell"},{"key":"2026071717020451400_xaag005-B34","doi-asserted-by":"crossref","first-page":"105616","DOI":"10.1016\/j.jbc.2023.105616","article-title":"Regulation of protein O-GlcNAcylation by circadian, metabolic, and cellular signals","volume":"300","author":"Liu","year":"2024","journal-title":"The Journal of Biological Chemistry"},{"key":"2026071717020451400_xaag005-B35","doi-asserted-by":"crossref","first-page":"e2303448120","DOI":"10.1073\/pnas.2303448120","article-title":"ER chaperone GRP78\/BiP translocates to the nucleus under stress and acts as a transcriptional regulator","volume":"120","author":"Liu","year":"2023","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"2026071717020451400_xaag005-B36","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1038\/cdd.2017.35","article-title":"Activation of cell surface GRP78 decreases endoplasmic reticulum stress and neuronal death","volume":"24","author":"Louessard","year":"2017","journal-title":"Cell Death and Differentiation"},{"key":"2026071717020451400_xaag005-B37","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/procel\/pwad063","article-title":"Aging hallmarks of the primate ovary revealed by spatiotemporal transcriptomics","volume":"15","author":"Lu","year":"2024","journal-title":"Protein & Cell"},{"key":"2026071717020451400_xaag005-B38","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.devcel.2017.09.019","article-title":"Channel nucleoporins recruit PLK-1 to nuclear pore complexes to direct nuclear envelope breakdown in C. elegans","volume":"43","author":"Martino","year":"2017","journal-title":"Developmental Cell"},{"key":"2026071717020451400_xaag005-B39","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1093\/biolre\/ioab013","article-title":"Evidence and manipulation of O-GlcNAcylation in granulosa cells of bovine antral follicles\u2020","volume":"104","author":"Maucieri","year":"2021","journal-title":"Biology of Reproduction"},{"key":"2026071717020451400_xaag005-B40","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1210\/jcem-49-5-687","article-title":"The production of progesterone, androgens, and estrogens by granulosa cells, thecal tissue, and stromal tissue from human ovaries in vitro","volume":"49","author":"McNatty","year":"1979","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"2026071717020451400_xaag005-B41","doi-asserted-by":"crossref","first-page":"7415","DOI":"10.1007\/s11356-022-22258-8","article-title":"Increased risk of primary ovarian insufficiency by high-fructose diet consumption: A 90-day study in female rats","volume":"30","author":"Mirzaei","year":"2023","journal-title":"Environmental Science and Pollution Research International"},{"key":"2026071717020451400_xaag005-B42","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1016\/j.bbamcr.2013.06.008","article-title":"Quantitative regulation of nuclear pore complex proteins by O-GlcNAcylation","volume":"1833","author":"Mizuguchi-Hata","year":"2013","journal-title":"Biochimica et biophysica acta"},{"key":"2026071717020451400_xaag005-B43","article-title":"A single-cell atlas of the cycling murine ovary","volume":"11, e77239","author":"Morris","year":"2022","journal-title":"eLife"},{"key":"2026071717020451400_xaag005-B44","doi-asserted-by":"crossref","first-page":"eadf7826","DOI":"10.1126\/sciadv.adf7826","article-title":"Mechanisms of nuclear pore complex disassembly by the mitotic Polo-like kinase 1 (PLK-1) in C. elegans embryos","volume":"9","author":"Nkombo Nkoula","year":"2023","journal-title":"Science Advances"},{"key":"2026071717020451400_xaag005-B45","doi-asserted-by":"crossref","first-page":"e13338","DOI":"10.1111\/acel.13338","article-title":"Cellular aging beyond cellular senescence: Markers of senescence prior to cell cycle arrest in vitro and in vivo","volume":"20","author":"Ogrodnik","year":"2021","journal-title":"Aging Cell"},{"key":"2026071717020451400_xaag005-B46","doi-asserted-by":"crossref","DOI":"10.3390\/genes14040933","article-title":"The hexosamine biosynthesis pathway: Regulation and function","volume":"14","author":"Paneque","year":"2023","journal-title":"Genes (Basel)"},{"key":"2026071717020451400_xaag005-B47","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1038\/s12276-021-00643-6","article-title":"Disruption of nucleocytoplasmic trafficking as a cellular senescence driver","volume":"53","author":"Park","year":"2021","journal-title":"Experimental & Molecular Medicine"},{"key":"2026071717020451400_xaag005-B48","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41420-023-01433-x","article-title":"Age-related elevation of O-GlcNAc causes meiotic arrest in male mice","volume":"9","author":"Qian","year":"2023","journal-title":"Cell Death Discovery"},{"key":"2026071717020451400_xaag005-B49","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1002\/ijc.27316","article-title":"Cellular senescence and tumor suppressor gene p16","volume":"130","author":"Rayess","year":"2012","journal-title":"International Journal of Cancer"},{"key":"2026071717020451400_xaag005-B50","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s13048-019-0565-6","article-title":"Induced premature ovarian insufficiency by using D galactose and its effects on reproductive profiles in small laboratory animals: a systematic review","volume":"12","author":"Rostami Dovom","year":"2019","journal-title":"Journal of Ovarian Research"},{"key":"2026071717020451400_xaag005-B51","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s12195-016-0440-0","article-title":"O-GlcNAc-ylation in the nuclear pore complex","volume":"9","author":"Ruba","year":"2016","journal-title":"Cellular and Molecular Bioengineering"},{"key":"2026071717020451400_xaag005-B52","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1101\/gad.235184.113","article-title":"Cellular senescence and its effector programs","volume":"28","author":"Salama","year":"2014","journal-title":"Genes & Development"},{"key":"2026071717020451400_xaag005-B53","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1006\/excr.1993.1060","article-title":"Modulation of the phosphorylation of glucose-regulated protein, GRP78, by transformation and inhibition of glycosylation","volume":"205","author":"Satoh","year":"1993","journal-title":"Experimental Cell Research"},{"key":"2026071717020451400_xaag005-B54","doi-asserted-by":"crossref","first-page":"18370","DOI":"10.1074\/jbc.M115.663500","article-title":"Ordered regions of channel nucleoporins Nup62, Nup54, and Nup58 form dynamic complexes in solution","volume":"290","author":"Sharma","year":"2015","journal-title":"The Journal of Biological Chemistry"},{"key":"2026071717020451400_xaag005-B55","doi-asserted-by":"crossref","first-page":"31","DOI":"10.33549\/physiolres.935485","article-title":"Mechanisms of granulosa cell programmed cell death and follicular atresia in polycystic ovary syndrome","volume":"74","author":"Shen","year":"2025","journal-title":"Physiological Research"},{"key":"2026071717020451400_xaag005-B56","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ydbio.2004.11.027","article-title":"Oocyte control of metabolic cooperativity between oocytes and companion granulosa cells: energy metabolism","volume":"279","author":"Sugiura","year":"2005","journal-title":"Developmental Biology"},{"key":"2026071717020451400_xaag005-B57","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/s41580-024-00738-8","article-title":"SenNet recommendations for detecting senescent cells in different tissues","volume":"25","author":"Suryadevara","year":"2024","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"2026071717020451400_xaag005-B58","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1016\/j.ajpath.2024.08.012","article-title":"Testosterone-induced H3K27 deacetylation participates in granulosa cell proliferation suppression and pathogenesis of polycystic ovary syndrome","volume":"194","author":"Tong","year":"2024","journal-title":"The American Journal of Pathology"},{"key":"2026071717020451400_xaag005-B59","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25042103","article-title":"Special issue \u201crole of apoptosis and cellular senescence in cancer and aging\u201d","volume":"25","author":"Tzoneva","year":"2024","journal-title":"International Journal of Molecular Sciences"},{"key":"2026071717020451400_xaag005-B60","doi-asserted-by":"crossref","first-page":"e13303","DOI":"10.1111\/cpr.13303","article-title":"Administration of nicotinamide mononucleotide improves oocyte quality of obese mice","volume":"55","author":"Wang","year":"2022","journal-title":"Cell Proliferation"},{"key":"2026071717020451400_xaag005-B61","doi-asserted-by":"crossref","first-page":"e359","DOI":"10.1002\/ctm2.359","article-title":"PIM2-mediated phosphorylation contributes to granulosa cell survival via resisting apoptosis during folliculogenesis","volume":"11","author":"Wang","year":"2021","journal-title":"Clinical and Translational Medicine"},{"key":"2026071717020451400_xaag005-B62","doi-asserted-by":"crossref","first-page":"e37427","DOI":"10.1371\/journal.pone.0037427","article-title":"Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates Akt signaling","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"key":"2026071717020451400_xaag005-B63","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.cell.2020.01.009","article-title":"Single-cell transcriptomic atlas of primate ovarian aging","volume":"180","author":"Wang","year":"2020","journal-title":"Cell"},{"key":"2026071717020451400_xaag005-B64","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.gene.2018.10.006","article-title":"miR-323-3p regulates the steroidogenesis and cell apoptosis in polycystic ovary syndrome (PCOS) by targeting IGF-1","volume":"683","author":"Wang","year":"2019","journal-title":"Gene"},{"key":"2026071717020451400_xaag005-B65","article-title":"Disruption of O-GlcNAcylation homeostasis induced ovarian granulosa cell injury in bovine","volume":"23","author":"Wang","year":"2022","journal-title":"International Journal of Molecular Sciences"},{"key":"2026071717020451400_xaag005-B66","doi-asserted-by":"crossref","first-page":"13793","DOI":"10.1073\/pnas.0806216105","article-title":"Cross-talk between GlcNAcylation and phosphorylation: site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc","volume":"105","author":"Wang","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"2026071717020451400_xaag005-B67","doi-asserted-by":"crossref","first-page":"ra2","DOI":"10.1126\/scisignal.2000526","article-title":"Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis","volume":"3","author":"Wang","year":"2010","journal-title":"Science Signaling"},{"key":"2026071717020451400_xaag005-B68","first-page":"E3723","article-title":"Bidirectional communication between oocytes and ovarian follicular somatic cells is required for meiotic arrest of mammalian oocytes","volume":"110","author":"Wigglesworth","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"2026071717020451400_xaag005-B69","doi-asserted-by":"crossref","first-page":"107141","DOI":"10.1016\/j.jbc.2024.107141","article-title":"OGT and OGA: Sweet guardians of the genome","volume":"300","author":"Wu","year":"2024","journal-title":"The Journal of Biological Chemistry"},{"key":"2026071717020451400_xaag005-B70","doi-asserted-by":"crossref","first-page":"20764","DOI":"10.1038\/srep20764","article-title":"Effects of glucose metabolism during in vitro maturation on cytoplasmic maturation of mouse oocytes","volume":"6","author":"Xie","year":"2016","journal-title":"Scientific Reports"},{"key":"2026071717020451400_xaag005-B71","doi-asserted-by":"crossref","first-page":"e456","DOI":"10.1002\/mco2.456","article-title":"O-GlcNAcylation: Cellular physiology and therapeutic target for human diseases","volume":"4","author":"Ye","year":"2023","journal-title":"MedComm (2020)"},{"key":"2026071717020451400_xaag005-B72","doi-asserted-by":"crossref","first-page":"366","DOI":"10.7150\/ijms.80189","article-title":"Role of obesity in female reproduction","volume":"20","author":"Yong","year":"2023","journal-title":"International Journal of Medical Sciences"},{"key":"2026071717020451400_xaag005-B73","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202010141","article-title":"O-GlcNAc modification of nuclear pore complexes accelerates bidirectional transport","volume":"220","author":"Yoo","year":"2021","journal-title":"The Journal of Cell Biology"},{"key":"2026071717020451400_xaag005-B74","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/nchembio.96","article-title":"A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo","volume":"4","author":"Yuzwa","year":"2008","journal-title":"Nature Chemical Biology"},{"key":"2026071717020451400_xaag005-B75","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1242\/jcs.053678","article-title":"The intersections between O-GlcNAcylation and phosphorylation: implications for multiple signaling pathways","volume":"123","author":"Zeidan","year":"2010","journal-title":"Journal of Cell Science"},{"key":"2026071717020451400_xaag005-B76","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/s41401-023-01218-z","article-title":"O-GlcNAcylation mediates H(2)O(2)-induced apoptosis through regulation of STAT3 and FOXO1","volume":"45","author":"Zhang","year":"2024","journal-title":"Acta Pharmacologica Sinica"},{"key":"2026071717020451400_xaag005-B77","article-title":"Essential role of granulosa cell glucose and lipid metabolism on oocytes and the potential metabolic imbalance in polycystic ovary syndrome","volume":"24","author":"Zhang","year":"2023","journal-title":"International Journal of Molecular Sciences"},{"key":"2026071717020451400_xaag005-B78","doi-asserted-by":"crossref","first-page":"109886","DOI":"10.1016\/j.cbi.2022.109886","article-title":"OGT as potential novel target: Structure, function and inhibitors","volume":"357","author":"Zhang","year":"2022","journal-title":"Chemico-Biological Interactions"},{"key":"2026071717020451400_xaag005-B79","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s41419-022-04541-1","article-title":"Enhanced glycolysis in granulosa cells promotes the activation of primordial follicles through mTOR signaling","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death & Disease"},{"key":"2026071717020451400_xaag005-B80","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13048-025-01651-0","article-title":"Granulosa cell-specific FOXJ2 overexpression induces premature ovarian insufficiency by triggering apoptosis via mitochondrial calcium overload","volume":"18","author":"Zhang","year":"2025","journal-title":"Journal of Ovarian Research"},{"key":"2026071717020451400_xaag005-B81","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1002\/mrd.23131","article-title":"Disruption of O-GlcNAc homeostasis during mammalian oocyte meiotic maturation impacts fertilization","volume":"86","author":"Zhou","year":"2019","journal-title":"Molecular Reproduction and Development"},{"key":"2026071717020451400_xaag005-B82","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/j.cmet.2023.09.009","article-title":"High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate","volume":"35","author":"Zhou","year":"2023","journal-title":"Cell Metabolism"},{"key":"2026071717020451400_xaag005-B83","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/jmcb\/mjv033","article-title":"Post-translational O-GlcNAcylation is essential for nuclear pore integrity and maintenance of the pore selectivity filter","volume":"8","author":"Zhu","year":"2016","journal-title":"Journal of Molecular Cell Biology"}],"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/reproduction\/advance-article-pdf\/doi\/10.1093\/reprod\/xaag005\/66557929\/xaag005.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/171\/2\/xaag005\/66557929\/xaag005.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/171\/2\/xaag005\/66557929\/xaag005.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T21:02:21Z","timestamp":1784322141000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/doi\/10.1093\/reprod\/xaag005\/8439660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,23]]},"references-count":83,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,5]]}},"URL":"https:\/\/doi.org\/10.1093\/reprod\/xaag005","relation":{},"ISSN":["1741-7899"],"issn-type":[{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,2]]},"published":{"date-parts":[[2026,1,23]]},"article-number":"xaag005"}}