{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T03:45:55Z","timestamp":1793245555248,"version":"4.5.0"},"reference-count":147,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["FT# FT210100193"],"award-info":[{"award-number":["FT# FT210100193"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Preeclampsia is a life-threatening pregnancy complication, resulting in &amp;gt;70,000 maternal deaths and &amp;gt;500,000 fetal and neonatal deaths worldwide each year. Despite its prevalence and devastating consequences, there is still no medical therapy to halt disease progression and thus a vital need for novel treatments remains. The urgent demand for effective therapies for preeclampsia first necessitates a deeper understanding of the pathogenesis that underpins the condition. Understanding the coordinated interactions between the maternal vasculature and circulating pathogenic factors released from the placenta is a key focus in preeclampsia research. Extracellular vesicles are membrane-bound vesicles that act as essential mediators of cell\u2013cell signalling. Extracellular vesicles are proposed to play a crucial role as regulators in placental\u2013maternal vascular communication. This \u00adreview explores contemporary literature investigating the role of placental-derived extracellular vesicles and their contribution to preeclampsia. Importantly, we provide a summary of key literature that should assist decision making for selection of models to study the role of extracellular vesicles in preeclampsia progression and their potential as therapeutic targets.<\/jats:p>","DOI":"10.1093\/reprod\/xaag011","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T12:34:36Z","timestamp":1768307676000},"source":"Crossref","is-referenced-by-count":8,"title":["Exploring placental dysfunction: models of extracellular vesicle action in preeclampsia"],"prefix":"10.1093","volume":"171","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1908-784X","authenticated-orcid":false,"given":"Bianca R","family":"Fato","sequence":"first","affiliation":[{"name":"Therapeutics Discovery and Vascular Function in Pregnancy Group, University of Melbourne , Heidelberg, Victoria 3084,","place":["Australia"]},{"name":"Department of Obstetrics, Gynaecology and Newborn Health, Mercy Hospital for Women, University of Melbourne , Heidelberg, Victoria 3084,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8376-0096","authenticated-orcid":false,"given":"Natasha","family":"de Alwis","sequence":"additional","affiliation":[{"name":"Therapeutics Discovery and Vascular Function in Pregnancy Group, University of Melbourne , Heidelberg, Victoria 3084,","place":["Australia"]},{"name":"Department of Obstetrics, Gynaecology and Newborn Health, Mercy Hospital for Women, University of Melbourne , Heidelberg, Victoria 3084,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8446-2250","authenticated-orcid":false,"given":"Natalie J","family":"Hannan","sequence":"additional","affiliation":[{"name":"Therapeutics Discovery and Vascular Function in Pregnancy Group, University of Melbourne , Heidelberg, Victoria 3084,","place":["Australia"]},{"name":"Department of Obstetrics, Gynaecology and Newborn Health, Mercy Hospital for Women, University of Melbourne , Heidelberg, Victoria 3084,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"2026041912170053000_xaag011-B1","doi-asserted-by":"publisher","first-page":"e0140879","DOI":"10.1371\/journal.pone.0140879","article-title":"Development of non-viral, trophoblast-\u00adspecific gene delivery for placental therapy","volume":"10","author":"Abd Ellah","year":"2015","journal-title":"PLoS One"},{"key":"2026041912170053000_xaag011-B2","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s10571-016-0366-z","article-title":"Introduction to extracellular vesicles: Biogenesis, RNA cargo selection, content, release, and uptake","volume":"36","author":"Abels","year":"2016","journal-title":"Cellular and Molecular 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