{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T03:47:11Z","timestamp":1784864831068,"version":"3.55.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universit\u00e9 Sherbrooke, Centre de Recherche de l\u2019H\u00f4pital Universitaire de Sherbrooke and Diab\u00e8te Qu\u00e9b\u00e9c"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,15]]},"abstract":"<jats:title>In brief<\/jats:title>\n                  <jats:p>Testosterone and lipids concentrations are higher in the follicular fluid of women with polycystic ovary syndrome. In addition, lipid metabolism seems to be dysfunctional in women affected by polycystic ovary syndrome.<\/jats:p>\n                  <jats:p>Abstract<\/jats:p>\n                  <jats:p>Evidence suggests that lipotoxicity can cause hyperandrogenesis, but little is known about the intra-ovarian environment of women with polycystic ovary syndrome (PCOS) and whether it displays features associated with lipotoxicity. The objective of this secondary analysis was to compare follicular fluid concentrations of testosterone, markers of lipid, lipid metabolism, and inflammation between women with PCOS and without PCOS. We conducted a controlled cross-sectional study on 80 participants. Medical records were used to determine PCOS diagnosis: 15 women were identified as having PCOS, while 65 had a negative diagnosis. Inclusion criteria were age between 18 and 40\u2009years old with a body mass index raging between 18 and 40\u2009kg\/m2. Follicular fluid was analysed for total testosterone, non-esterified fatty acids (NEFA), triglycerides, NEFA metabolites (acylcarnitines and C16\/C13 ratio), and inflammatory cytokines. Compared to women without PCOS, women with PCOS had increased follicular fluid levels of testosterone (7.08\u2009nM versus 0.29\u2009nM), triglycerides (0.30\u2009nM versus 0.17\u2009nM), palmitoylcarnitine (43.7\u2009nM versus 28.4\u2009nM), and interleukin (IL)-6 (13.04\u2009pg\/ml versus 8.9\u2009pg\/ml), while tumor necrosis factor alpha remained similar. These differences remained statistically different after adjustment for body mass index, except for IL-6. These group differences were also confirmed in paired analyses of 13 body mass index-matched pairs of PCOS versus non-PCOS women, with the exception of IL-6. In conclusion, intra-ovarian inflammation, but more importantly, lipid overexposure, may play a role in the pathogenesis of PCOS, probably through lipotoxic effects.<\/jats:p>","DOI":"10.1093\/reprod\/xaag025","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T12:39:14Z","timestamp":1771072754000},"source":"Crossref","is-referenced-by-count":1,"title":["Comparison of intra-ovarian metabolic environment between women with or without polycystic ovary syndrome undergoing in vitro fertilization"],"prefix":"10.1093","volume":"171","author":[{"given":"Alexandre","family":"Gervais","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Universit\u00e9 de Sherbrooke , Sherbrooke, Quebec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giada","family":"Ostinelli","sequence":"additional","affiliation":[{"name":"University of Montreal Hospital Research Centre and Department of Medecine, University of Montreal , Montr\u00e9al, Quebec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanie","family":"Faubert","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Universit\u00e9 de Sherbrooke , Sherbrooke, Quebec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Claude","family":"Battista","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Universit\u00e9 de Sherbrooke , Sherbrooke, Quebec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belina","family":"Carranza-Mamane","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Universit\u00e9 de Sherbrooke , Sherbrooke, Quebec,","place":["Canada"]},{"name":"PROCR\u00c9A Fertilit\u00e9 Montreal , Qu\u00e9bec,","place":["Canada"]},{"name":"Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke , Sherbrooke, Quebec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne B","family":"Lavoie","sequence":"additional","affiliation":[{"name":"PROCR\u00c9A Fertilit\u00e9 Montreal , Qu\u00e9bec,","place":["Canada"]},{"name":"Centre Hospitalier Universitaire de Montr\u00e9al Division of Endocrinology, , Montr\u00e9al, Quebec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1336-081X","authenticated-orcid":false,"given":"Jean-Patrice","family":"Baillargeon","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Universit\u00e9 de Sherbrooke , Sherbrooke, Quebec,","place":["Canada"]},{"name":"Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke , Sherbrooke, Quebec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,2,15]]},"reference":[{"key":"2026031613114456900_xaag025-B1","doi-asserted-by":"publisher","first-page":"105","DOI":"10.22074\/ijfs.2017.4704","article-title":"Evaluation of relationship between body mass index with vitamin D receptor gene expression and vitamin D levels of follicular fluid in overweight patients with polycystic ovary syndrome","volume":"11","author":"Aghadavod","year":"2017","journal-title":"International Journal of Fertility & Sterility"},{"key":"2026031613114456900_xaag025-B2","doi-asserted-by":"publisher","first-page":"4237","DOI":"10.1210\/jc.2006-0178","article-title":"Positions statement: Criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: An androgen excess society guideline","volume":"91","author":"Azziz","year":"2006","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"2026031613114456900_xaag025-B3","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.jsbmb.2009.12.010","article-title":"Insulin and hyperandrogenism in women with polycystic ovary syndrome","volume":"122","author":"Baptiste","year":"2010","journal-title":"The Journal of Steroid Biochemistry and Molecular Biology"},{"key":"2026031613114456900_xaag025-B4","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.steroids.2011.12.017","article-title":"Saturated fatty acid exposure induces androgen overproduction in bovine adrenal cells","volume":"77","author":"Bellanger","year":"2012","journal-title":"Steroids"},{"key":"2026031613114456900_xaag025-B5","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1016\/j.mcna.2008.04.008","article-title":"Basic infertility including polycystic ovary syndrome","volume":"92","author":"Brassard","year":"2008","journal-title":"The Medical Clinics of North America"},{"key":"2026031613114456900_xaag025-B6","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.3390\/biomedicines10061254","article-title":"Follicular fluid: a powerful tool for the understanding and diagnosis of polycystic ovary syndrome","volume":"10","author":"Brinca","year":"2022","journal-title":"Biomedicines"},{"key":"2026031613114456900_xaag025-B7","doi-asserted-by":"publisher","first-page":"399","DOI":"10.2337\/diabetes.49.3.399","article-title":"Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes","volume":"49","author":"Carpentier","year":"2000","journal-title":"Diabetes"},{"key":"2026031613114456900_xaag025-B8","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.diabet.2007.10.009","article-title":"Postprandial fatty acid metabolism in the development of lipotoxicity and type 2 diabetes","volume":"34","author":"Carpentier","year":"2008","journal-title":"Diabetes & Metabolism"},{"key":"2026031613114456900_xaag025-B9","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.steroids.2013.05.001","article-title":"Androgens inhibit adipogenesis during human adipose stem cell commitment to preadipocyte formation","volume":"78","author":"Chazenbalk","year":"2013","journal-title":"Steroids"},{"key":"2026031613114456900_xaag025-B10","doi-asserted-by":"publisher","first-page":"5324","DOI":"10.1210\/jcem.86.11.8060","article-title":"Metabolic and endocrine consequences of acute suppression of ffas by acipimox in polycystic ovary syndrome","volume":"86","author":"Ciampelli","year":"2001","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"2026031613114456900_xaag025-B11","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/s40618-017-0762-3","article-title":"Androgen excess and metabolic disorders in women with pcos: Beyond the body mass index","volume":"41","author":"Condorelli","year":"2018","journal-title":"Journal of Endocrinological Investigation"},{"key":"2026031613114456900_xaag025-B12","doi-asserted-by":"publisher","first-page":"4315413","DOI":"10.1155\/2018\/4315413","article-title":"Role of lipotoxicity and contribution of the renin-angiotensin system in the development of polycystic ovary syndrome","volume":"2018","author":"Connolly","year":"2018","journal-title":"International Journal of Endocrinology"},{"key":"2026031613114456900_xaag025-B13","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1002\/iub.142","article-title":"Intramuscular lipid metabolism, insulin action, and obesity","volume":"61","author":"Consitt","year":"2009","journal-title":"IUBMB Life"},{"key":"2026031613114456900_xaag025-B14","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1093\/humrep\/des349","article-title":"The follicular hormonal profile in low-responder patients undergoing unstimulated cycles: Is it hypoandrogenic?","volume":"28","author":"de los Santos","year":"2013","journal-title":"Human Reproduction (Oxford, England)"},{"key":"2026031613114456900_xaag025-B15","doi-asserted-by":"publisher","first-page":"960274","DOI":"10.3389\/fendo.2022.960274","article-title":"Follicular fluid lipidomic profiling reveals potential biomarkers of polycystic ovary syndrome: A pilot study","volume":"13","author":"Ding","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2026031613114456900_xaag025-B16","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.2527\/jas.2015-0089","article-title":"Physiology and endocrinology symposium: Insulin action and lipotoxicity in the development of polycystic ovary syndrome: A review","volume":"94","author":"Faubert","year":"2016","journal-title":"Journal of Animal Science"},{"key":"2026031613114456900_xaag025-B17","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1210\/jc.2014-3649","article-title":"Follicular fluid concentrations of lipids and their metabolites are associated with intraovarian gonadotropin-stimulated androgen production in women undergoing in vitro fertilization","volume":"100","author":"Gervais","year":"2015","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"2026031613114456900_xaag025-B6612952","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1677\/joe.1.06579","article-title":"In vitro evidence that hyperglycemia stimulates tumor necrosis factor-alpha release in obese women with polycystic ovary syndrome","volume":"188","author":"Gonz\u00e1lez","year":"2006","journal-title":"The Journal of Endocrinology"},{"key":"2026031613114456900_xaag025-B18","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1093\/humupd\/dmi036","article-title":"A meta-analysis of outcomes of conventional ivf in women with polycystic ovary syndrome","volume":"12","author":"Heijnen","year":"2006","journal-title":"Human Reproduction Update"},{"key":"2026031613114456900_xaag025-B19","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1111\/j.1365-2265.1994.tb02577.x","article-title":"Serum lipoprotein lipid profile in women with the polycystic ovary syndrome: Relation to anthropometric, endocrine and metabolic variables","volume":"41","author":"Holte","year":"1994","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2026031613114456900_xaag025-B20","doi-asserted-by":"publisher","first-page":"4103","DOI":"10.1210\/jcem.81.11.8923867","article-title":"Ovarian 17-hydroxyprogesterone hyperresponsiveness to gonadotropin-releasing hormone (gnrh) agonist challenge in women with polycystic ovary syndrome is not mediated by luteinizing hormone hypersecretion: Evidence from gnrh agonist and human chorionic gonadotropin stimulation testing","volume":"81","author":"Iba\u00f1ez","year":"1996","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"2026031613114456900_xaag025-B21","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/s2213-8587(22)00163-2","article-title":"Polycystic ovary syndrome","volume":"10","author":"Joham","year":"2022","journal-title":"The Lancet. Diabetes & Endocrinology"},{"key":"2026031613114456900_xaag025-B22","doi-asserted-by":"publisher","first-page":"1970","DOI":"10.1016\/j.fertnstert.2011.01.154","article-title":"Associations between free fatty acids, cumulus oocyte complex morphology and ovarian function during in vitro fertilization","volume":"95","author":"Jungheim","year":"2011","journal-title":"Fertility and Sterility"},{"key":"2026031613114456900_xaag025-B23","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1161\/circresaha.106.142851","article-title":"Toll-like receptor-4 mediates vascular inflammation and \u00adinsulin \u00adresistance in diet-induced obesity","volume":"100","author":"Kim","year":"2007","journal-title":"Circulation Research"},{"key":"2026031613114456900_xaag025-B24","doi-asserted-by":"publisher","first-page":"13523","DOI":"10.1038\/s41598-020-70347-w","article-title":"Metformin reduces saturated fatty acid-induced lipid accumulation and inflammatory response by restoration of autophagic flux in endothelial cells","volume":"10","author":"Kim","year":"2020","journal-title":"Scientific Reports"},{"key":"2026031613114456900_xaag025-B25","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.cmet.2007.10.013","article-title":"Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance","volume":"7","author":"Koves","year":"2008","journal-title":"Cell Metabolism"},{"key":"2026031613114456900_xaag025-B26","doi-asserted-by":"publisher","first-page":"423","DOI":"10.3109\/09513590.2014.895981","article-title":"Interleukin-6 levels in relation with hormonal and metabolic profile in patients with polycystic ovary syndrome","volume":"30","author":"K\u00fc\u00e7\u00fck","year":"2014","journal-title":"Gynecological Endocrinology: The Official Journal of the International Society of Gynecological Endocrinology"},{"key":"2026031613114456900_xaag025-B27","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1210\/clinem\/dgac281","article-title":"Elevated levels of follicular fatty acids induce ovarian inflammation via erk1\/2 and inflammasome activation in pcos","volume":"107","author":"Lai","year":"2022","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"2026031613114456900_xaag025-B28","doi-asserted-by":"publisher","first-page":"3684","DOI":"10.1210\/en.2014-1185","article-title":"Angiotensin ii type 2 receptor stimulation improves fatty acid ovarian uptake and hyperandrogenemia in an obese rat model of polycystic ovary syndrome","volume":"155","author":"Leblanc","year":"2014","journal-title":"Endocrinology"},{"key":"2026031613114456900_xaag025-B29","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1139\/y08-014","article-title":"Lipid and lipoprotein profile in women with polycystic ovary syndrome","volume":"86","author":"Macut","year":"2008","journal-title":"Canadian Journal of Physiology and Pharmacology"},{"key":"2026031613114456900_xaag025-B30","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1210\/jc.2005-2069","article-title":"Free fatty acids increase androgen precursors in vivo","volume":"91","author":"Mai","year":"2006","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"2026031613114456900_xaag025-B31","doi-asserted-by":"publisher","first-page":"3900","DOI":"10.1210\/jc.2008-0714","article-title":"Intravenous lipid and heparin infusion-induced elevation in free fatty acids and triglycerides modifies circulating androgen levels in women: A randomized, controlled trial","volume":"93","author":"Mai","year":"2008","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"2026031613114456900_xaag025-B32","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1016\/j.fertnstert.2013.01.095","article-title":"Cost-effectiveness comparison between pituitary down-regulation with a gonadotropin-releasing hormone agonist short regimen on alternate days and an antagonist protocol for assisted fertilization treatments","volume":"99","author":"Maldonado","year":"2013","journal-title":"Fertility and Sterility"},{"key":"2026031613114456900_xaag025-B33","doi-asserted-by":"publisher","first-page":"1984","DOI":"10.1093\/humrep\/dez161","article-title":"Mitochondria-targeted therapy rescues development and quality of embryos derived from oocytes matured under oxidative stress conditions: A bovine in vitro model","volume":"34","author":"Marei","year":"2019","journal-title":"Human Reproduction (Oxford, England)"},{"key":"2026031613114456900_xaag025-B34","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/s13287-018-0950-x","article-title":"New insights into the genic and metabolic characteristics of induced pluripotent stem cells from polycystic ovary syndrome women","volume":"9","author":"Min","year":"2018","journal-title":"Stem Cell Research & Therapy"},{"key":"2026031613114456900_xaag025-B35","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1093\/humrep\/15.6.1266","article-title":"Insulin sensitivity, insulin secretion, and metabolic and hormonal parameters in healthy women and women with polycystic ovarian syndrome","volume":"15","author":"Morin-Papunen","year":"2000","journal-title":"Human Reproduction (Oxford, England)"},{"key":"2026031613114456900_xaag025-B36","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.fertnstert.2023.11.008","article-title":"Fertility treatment pathways and births for women with and without polycystic ovary syndrome-a retrospective population linked data study","volume":"121","author":"Moss","year":"2024","journal-title":"Fertility and Sterility"},{"key":"2026031613114456900_xaag025-B37","doi-asserted-by":"publisher","first-page":"2228","DOI":"10.1016\/j.fertnstert.2009.12.081","article-title":"Steroid profiles in ovarian follicular fluid in women with and without polycystic ovary syndrome, analyzed by liquid chromatography-tandem mass spectrometry","volume":"94","author":"Naessen","year":"2010","journal-title":"Fertility and Sterility"},{"key":"2026031613114456900_xaag025-B38","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1007\/s001250051041","article-title":"Lowering fatty acids potentiates acute insulin response in first degree relatives of people with type ii diabetes","volume":"41","author":"Paolisso","year":"1998","journal-title":"Diabetologia"},{"key":"2026031613114456900_xaag025-B39","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2021"},{"key":"2026031613114456900_xaag025-B40","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s13048-019-0606-1","article-title":"Lipid droplets in granulosa cells are correlated with reduced pregnancy rates","volume":"13","author":"Raviv","year":"2020","journal-title":"Journal of Ovarian Research"},{"key":"2026031613114456900_xaag025-B41","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1095\/biolreprod.109.082941","article-title":"Formation of the ovarian follicular antrum and follicular fluid","volume":"82","author":"Rodgers","year":"2010","journal-title":"Biology of Reproduction"},{"key":"2026031613114456900_xaag025-B42","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/j.jpeds.2012.11.019","article-title":"Using the androgen excess-pcos society criteria to diagnose polycystic ovary syndrome and the risk of metabolic syndrome in adolescents","volume":"162","author":"Roe","year":"2013","journal-title":"The Journal of Pediatrics"},{"key":"2026031613114456900_xaag025-B43","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","author":"Rotterdam ESHRE\/ASRM-Sponsored PCOS consensus workshop group","year":"2004","journal-title":"Fertil Steril"},{"key":"2026031613114456900_xaag025-B44","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/s0026-0495(03)00102-1","article-title":"Insulin secretion after short- and long-term low-grade free fatty acid infusion in men with increased risk of developing type 2 diabetes","volume":"52","author":"Storgaard","year":"2003","journal-title":"Metabolism: clinical and Experimental"},{"key":"2026031613114456900_xaag025-B45","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1080\/09513590701507817","article-title":"Impaired growth hormone secretion after glucose loading in non-obese women with polycystic ovary syndrome, possibly related to androgen but not insulin and free fatty acids","volume":"23","author":"Takeuchi","year":"2007","journal-title":"Gynecological Endocrinology: The Official Journal of the International Society of Gynecological Endocrinology"},{"key":"2026031613114456900_xaag025-B46","doi-asserted-by":"publisher","first-page":"2471","DOI":"10.1093\/humrep\/15.12.2471","article-title":"Comparison of follicle steroidogenesis from normal and polycystic ovaries in women undergoing ivf: Relationship between steroid concentrations, follicle size, oocyte quality and fecundability","volume":"15","author":"Teissier","year":"2000","journal-title":"Human Reproduction (Oxford, England)"},{"key":"2026031613114456900_xaag025-B47","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1093\/humrep\/deu044","article-title":"Gonadotrophin stimulation for in vitro fertilization significantly alters the hormone milieu in follicular fluid: A comparative study between natural cycle ivf and conventional ivf","volume":"29","author":"von Wolff","year":"2014","journal-title":"Human Reproduction (Oxford, England)"},{"key":"2026031613114456900_xaag025-B48","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/j.rbmo.2017.07.012","article-title":"Serum and follicular fluid testosterone concentrations do not correlate, questioning the impact of androgen supplementation on the follicular endocrine milieu","volume":"35","author":"von Wolff","year":"2017","journal-title":"Reproductive Biomedicine Online"},{"key":"2026031613114456900_xaag025-B49","doi-asserted-by":"publisher","first-page":"E658","DOI":"10.1152\/ajpendo.00511.2013","article-title":"Early mitochondrial dysfunction in glycolytic muscle, but not oxidative muscle, of the fructose-fed insulin-resistant rat","volume":"306","author":"Warren","year":"2014","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"key":"2026031613114456900_xaag025-B50","doi-asserted-by":"publisher","first-page":"5438","DOI":"10.1210\/en.2010-0551","article-title":"High-fat diet causes lipotoxicity responses in cumulus-oocyte complexes and decreased fertilization rates","volume":"151","author":"Wu","year":"2010","journal-title":"Endocrinology"},{"key":"2026031613114456900_xaag025-B51","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.fertnstert.2007.11.031","article-title":"Increased acylation-stimulating protein, c-reactive protein, and lipid levels in young women with polycystic ovary syndrome","volume":"91","author":"Wu","year":"2009","journal-title":"Fertility and Sterility"},{"key":"2026031613114456900_xaag025-B52","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.ejogrb.2011.07.012","article-title":"Low-grade chronic inflammation in the peripheral blood and ovaries of women with polycystic ovarian syndrome","volume":"159","author":"Xiong","year":"2011","journal-title":"European Journal of Obstetrics, Gynecology, and Reproductive Biology"},{"key":"2026031613114456900_xaag025-B53","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.rbmo.2020.09.024","article-title":"Fatty acids of follicular fluid phospholipids and triglycerides display distinct association with ivf outcomes","volume":"42","author":"Zarezadeh","year":"2021","journal-title":"Reproductive Biomedicine Online"}],"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/reproduction\/advance-article-pdf\/doi\/10.1093\/reprod\/xaag025\/66903651\/xaag025.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/171\/3\/xaag025\/66903651\/xaag025.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/171\/3\/xaag025\/66903651\/xaag025.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:11:53Z","timestamp":1773681113000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/doi\/10.1093\/reprod\/xaag025\/8484135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,15]]},"references-count":54,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3,15]]}},"URL":"https:\/\/doi.org\/10.1093\/reprod\/xaag025","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,3]]},"published":{"date-parts":[[2026,2,15]]},"article-number":"xaag025"}}