{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:57:04Z","timestamp":1781715424816,"version":"3.54.5"},"reference-count":60,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Hatch Project","award":["WIS01240 to M.C.W."],"award-info":[{"award-number":["WIS01240 to M.C.W."]}]},{"name":"USDA-NIFA project","award":["2019\u201367015-29704"],"award-info":[{"award-number":["2019\u201367015-29704"]}]},{"name":"USDA-NIFA project","award":["2022\u201367015-36372 to M.C.W."],"award-info":[{"award-number":["2022\u201367015-36372 to M.C.W."]}]},{"name":"Judge John J. Crown Chair in Dairy Physiology, Nutrition, and Management to M.C.W."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In brief: Intrauterine infusion of PAGs maintains the bovine corpus luteum through a local ipsilateral mechanism.<\/jats:p>\n                  <jats:p>Abstract: Embryonic interferon-tau suppresses oxytocin-induced endometrial prostaglandin F2\u03b1 pulses, likely involved in maintaining the bovine corpus luteum (CL) during early pregnancy. After day 21 of bovine pregnancy, oxytocin-induced prostaglandin F2\u03b1 pulses are observed, yet luteal persistence continues through unknown mechanisms. Pregnancy-associated glycoproteins (PAGs), reported over 40\u2009years ago, increase as interferon-tau declines, but their physiological role remains undefined. We hypothesized that PAGs prevent CL regression. Holstein heifers were synchronized to ovulate on day 0. In study 1 (n\u2009=\u200912), heifers received ipsilateral intrauterine infusions every 48\u2009hr from days 14\u201324: saline (Control, n\u2009=\u20094), low-dose PAGs (0.635\u2009mg, n\u2009=\u20094), or high-dose PAGs (1.3\u2009mg, n\u2009=\u20094). Study 2 (n\u2009=\u200911) characterized natural circulating progesterone (P4) and PAG profiles from days 14 to 60 in pregnant heifers. Study 3 (n\u2009=\u200925) compared daily ipsilateral (n\u2009=\u20098) or contralateral (n\u2009=\u20099) intrauterine infusions of PAGs (2\u2009mg) versus bovine serum albumin control (2\u2009mg, n\u2009=\u20098). Luteal blood flow (color Doppler), plasma P4 (radioimmunoassay ), and PAG concentrations (enzyme-linked immunosorbent assay) were assessed. Results indicated luteal maintenance by PAGs. In study 1, PAG treatment delayed luteolysis (day 22 and 23 vs day 17 in Control; p\u2009&amp;lt;\u2009.0001). PAG concentrations during natural pregnancy (study 2) far exceeded those achieved by infusion (study 1). In study 3, luteal lifespan was prolonged in ipsilateral (day 25) relative to contralateral (day 20) PAG infusions or Control (day 16; p\u2009&amp;lt;\u2009.0001); however, oxytocin increased prostaglandin F metabolite in all groups. These results introduce a potential novel, local, intrauterine, antiluteolytic role for PAGs in the maintenance of the bovine CL of pregnancy.<\/jats:p>","DOI":"10.1093\/reprod\/xaag061","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:59:25Z","timestamp":1778673565000},"source":"Crossref","is-referenced-by-count":0,"title":["Evidence for a novel role of pregnancy-associated glycoproteins in maintenance of the bovine corpus luteum of pregnancy"],"prefix":"10.1093","author":[{"given":"Livia","family":"Martino-Duarte","sequence":"first","affiliation":[{"name":"Department of Animal and Dairy Sciences, University of Wisconsin-Madison , Madison, WI,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Paulo N","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences, University of Wisconsin-Madison , Madison, WI,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro L J","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences, University of Wisconsin-Madison , Madison, WI,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackson F","family":"Gille","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences, University of Wisconsin-Madison , Madison, WI,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Autumn R","family":"Joy","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences, University of Wisconsin-Madison , Madison, WI,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo S","family":"El Azzi","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences, University of Wisconsin-Madison , Madison, WI,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia N","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences, University of Wisconsin-Madison , Madison, WI,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasey L","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences, University of Wisconsin-Madison , Madison, WI,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Varelis","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences, University of Wisconsin-Madison , Madison, WI,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3481-5318","authenticated-orcid":false,"given":"Hilario C","family":"Mantovani","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences, University of Wisconsin-Madison , Madison, WI,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8188-0991","authenticated-orcid":false,"given":"Milo C","family":"Wiltbank","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences, University of Wisconsin-Madison , Madison, WI,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"2026061711583185200_xaag061-B1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.theriogenology.2024.08.014","article-title":"Identification of nonpregnant beef cows based on CL size vs. luteal blood perfusion at 21 days after timed artificial 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