{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T18:14:49Z","timestamp":1784139289417,"version":"3.55.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["#456828204"],"award-info":[{"award-number":["#456828204"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["#491030536"],"award-info":[{"award-number":["#491030536"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NHPs","award":["P51 OD011092"],"award-info":[{"award-number":["P51 OD011092"]}]},{"name":"ONPRC\/OHSU"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In brief: The RNA-binding protein Pumilio-2 (PUM2) is expressed by human granulosa cells and granulosa cell tumor cells, including KGN cells. Fundamental roles in the regulation of the innate immune abilities, proliferation, and steroidogenesis of KGN granulosa cells became apparent upon downregulation.<\/jats:p>\n                  <jats:p>Abstract: The RNA-binding protein Pumilio-2 (PUM2), encoded by PUM2, is known as a translational repressor with important roles \u00adduring embryonic development, cell differentiation, and synapse function. Information on its roles in the ovary were sparse, yet databank mining followed by immunohistochemistry revealed expression in nonhuman primate ovarian granulosa cells (GCs). Expression was also found in human in vitro fertilization\u2013derived GCs, samples of human GC tumors (GCTs), and KGN cells, a well-established GCT-derived cell line. KGN cells were used to explore the roles of PUM2. A small interfering RNA (siRNA) targeting PUM2 reduced PUM2 levels in KGN cells, as seen in a proteomic analysis, which also revealed that a total of 51 \u00adproteins were present at lower levels, while\u00a0the abundance of 66 proteins was increased. Gene Ontology term analyses showed that the pathways mainly decreased were \u201cresponse to virus,\u201d \u201cdefence response to virus,\u201d and \u201cinnate immune response.\u201d PUM2 may thus be a regulator of the innate immune abilities of GCs. The most increased pathway was \u201ccell division,\u201d in line with increased proliferation of siRNA-transfected KGN cells. This underlies the increased ability to close the gap in scratch assays, as individual cell velocity or directionality of migration were comparable to controls. Downregulation of PUM2 also impaired the steroidogenic potential of KGN cells (lower HSD3B2 levels, lower progesterone in supernatant). Taken together, the results indicate fundamental roles of PUM2 not only in in the regulation of proliferation and steroidogenesis of human granulosa cells, but also in regulation of their innate immune abilities.<\/jats:p>","DOI":"10.1093\/reprod\/xaag075","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:20:33Z","timestamp":1781612433000},"source":"Crossref","is-referenced-by-count":0,"title":["The RNA-binding protein Pumilio-2 has roles in the regulation of proliferation and innate immunity of human KGN granulosa tumor cells"],"prefix":"10.1093","volume":"172","author":[{"given":"Katja","family":"Eubler","sequence":"first","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t (LMU) M\u00fcnchen, Cell Biology, Biomedical Center (BMC), LMU Medizin, 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Planegg-Martinsried,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Berg","sequence":"additional","affiliation":[{"name":"Fertility Centre A.R.T. , Bogenhausen, Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Berg","sequence":"additional","affiliation":[{"name":"Fertility Centre A.R.T. , Bogenhausen, Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A","family":"Dissen","sequence":"additional","affiliation":[{"name":"Molecular Virology Core, Oregon Health & Science University (OHSU), Oregon National Primate Research Center , Beaverton, OR,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Mayr","sequence":"additional","affiliation":[{"name":"Institute of Pathology, LMU University Hospital, LMU Medizin, LMU, 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