{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:58:37Z","timestamp":1785218317193,"version":"3.55.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171642"],"award-info":[{"award-number":["82171642"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170641"],"award-info":[{"award-number":["32170641"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170612"],"award-info":[{"award-number":["32170612"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301825"],"award-info":[{"award-number":["82301825"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In brief: We present the first single-cell transcriptomic atlas of follicular fluid from an ovarian endometrioma (OMA) patient, revealing a novel TCR+ macrophage subtype, aberrant granulosa cell developmental trajectories, immune dysregulation, and enhanced MIF\/MK signaling, providing new insights into mechanisms underlying impaired follicular development in OMA.<\/jats:p>\n                  <jats:p>Abstract: Ovarian endometrioma (OMA), an endometriosis subtype, involves hemorrhagic cysts formed by ectopic endometrial-like tissue, causing pelvic pain, inflammation, and infertility by disrupting ovarian function. Despite its impact, the single-cell dynamics in OMA follicular fluid are poorly understood. We performed single-cell RNA sequencing (10x Genomics) on follicular fluid from a patient\u2019s affected (2,793 cells) and unaffected (4,699 cells; control) ovaries. Analysis revealed four cell types, including a novel TCR+ macrophage subtype. Affected-side granulosa cells showed abnormal developmental trajectories linked to dysregulated steroid pathways. Immune cells exhibited heightened inflammation and reduced macrophage phagocytosis. Cell\u2013cell communication highlighted prominent Macrophage Migration Inhibitory Factor and Midkine signaling from granulosa cells. This study provides the first single-cell transcriptomic profile of OMA follicular fluid, elucidating aberrant granulosa cell development, immune dysregulation, and distinctive cellular interactions, enhancing understanding of OMA\u2019s impact on follicular development and suggesting potential diagnostic\/therapeutic targets.<\/jats:p>","DOI":"10.1093\/reprod\/xaag083","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:41:58Z","timestamp":1783428118000},"source":"Crossref","is-referenced-by-count":0,"title":["Single-cell transcriptomic atlas of ovarian endometriosis patient\u2019s follicular fluid: unraveling novel insights into abnormal follicular development"],"prefix":"10.1093","volume":"172","author":[{"given":"Meng","family":"Zhang","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University , Guangzhou,","place":["China"]},{"name":"Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases , Guangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0346-684X","authenticated-orcid":false,"given":"Xinye","family":"Hu","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University , Guangzhou,","place":["China"]},{"name":"Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases , Guangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Lin","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University , Guangzhou,","place":["China"]},{"name":"Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases , Guangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Yang","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University , Guangzhou,","place":["China"]},{"name":"Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases , Guangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Ji","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University , Guangzhou,","place":["China"]},{"name":"Medical College, Jinan University , Guangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoqiu","family":"Wu","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University , Guangzhou,","place":["China"]},{"name":"Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases , Guangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunwei","family":"Cao","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University , Guangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yabin","family":"Guo","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University , Guangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingxue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University , Guangzhou,","place":["China"]},{"name":"Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases , Guangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"2026072801012982000_xaag083-B1","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/s41590-018-0276-y","article-title":"Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage","volume":"20","author":"Aran","year":"2019","journal-title":"Nature Immunology"},{"key":"2026072801012982000_xaag083-B2","doi-asserted-by":"publisher","first-page":"263","DOI":"10.3389\/fimmu.2015.00263","article-title":"Much more than M1 and M2 macrophages, there are also CD169(+) and TCR(+) macrophages","volume":"6","author":"Ch\u00e1vez-Gal\u00e1n","year":"2015","journal-title":"Frontiers in Immunology"},{"key":"2026072801012982000_xaag083-B3","doi-asserted-by":"publisher","first-page":"245","DOI":"10.3389\/fonc.2015.00245","article-title":"The extracellular matrix in epithelial ovarian cancer - a piece of a puzzle","volume":"5","author":"Cho","year":"2015","journal-title":"Frontiers in Oncology"},{"key":"2026072801012982000_xaag083-B4","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1126\/science.1116995","article-title":"Tissue cells feel and respond to the stiffness of their substrate","volume":"310","author":"Discher","year":"2005","journal-title":"Science (New York, N.Y.)"},{"key":"2026072801012982000_xaag083-B5","doi-asserted-by":"publisher","first-page":"114592","DOI":"10.1016\/j.ecoenv.2023.114592","article-title":"Microcystin-LR accelerates follicular atresia in mice via JNK-mediated adherent junction damage of ovarian granulosa cells","volume":"252","author":"Du","year":"2023","journal-title":"Ecotoxicology and Environmental Safety"},{"key":"2026072801012982000_xaag083-B6","doi-asserted-by":"publisher","first-page":"1226687","DOI":"10.3389\/fendo.2023.1226687","article-title":"Decreased oocyte quality in patients with endometriosis is closely related to abnormal granulosa cells","volume":"14","author":"Fan","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2026072801012982000_xaag083-B7","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1093\/humrep\/dez053","article-title":"Single-cell RNA sequencing of oocytes from ovarian endometriosis patients reveals a differential transcriptomic profile associated with lower quality","volume":"34","author":"Ferrero","year":"2019","journal-title":"Human Reproduction (Oxford, England)"},{"key":"2026072801012982000_xaag083-B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/humupd\/dmac031","article-title":"Biomechanical forces and signals operating in the ovary during folliculogenesis and their dysregulation: implications for fertility","volume":"29","author":"Fiorentino","year":"2023","journal-title":"Human Reproduction Update"},{"key":"2026072801012982000_xaag083-B9","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s13048-017-0342-3","article-title":"Follicular fluid redox involvement for ovarian follicle growth","volume":"10","author":"Freitas","year":"2017","journal-title":"Journal of Ovarian Research"},{"key":"2026072801012982000_xaag083-B10","doi-asserted-by":"publisher","first-page":"2784","DOI":"10.1074\/jbc.M703265200","article-title":"Macrophage migration inhibitory factor induces B cell survival by activation of a CD74-CD44 receptor complex","volume":"283","author":"Gore","year":"2008","journal-title":"The Journal of Biological Chemistry"},{"key":"2026072801012982000_xaag083-B11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s12916-019-1470-y","article-title":"Mass cytometry analysis reveals a distinct immune environment in peritoneal fluid in endometriosis: a characterisation study","volume":"18","author":"Guo","year":"2020","journal-title":"BMC Medicine"},{"key":"2026072801012982000_xaag083-B12","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1111\/j.1600-0897.2007.00522.x","article-title":"The presence of midkine and its possible implication in human ovarian follicles","volume":"58","author":"Hirota","year":"2007","journal-title":"American Journal of Reproductive Immunology (New York, N.Y.: 1989)"},{"key":"2026072801012982000_xaag083-B13","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1111\/bph.12311","article-title":"Midkine and cytoplasmic maturation of mammalian oocytes in the context of ovarian follicle physiology","volume":"171","author":"Ikeda","year":"2014","journal-title":"British Journal of Pharmacology"},{"key":"2026072801012982000_xaag083-B14","doi-asserted-by":"publisher","first-page":"2420","DOI":"10.1038\/onc.2010.615","article-title":"p70 S6 kinase in the control of actin cytoskeleton dynamics and directed migration of ovarian cancer cells","volume":"30","author":"Ip","year":"2011","journal-title":"Oncogene"},{"key":"2026072801012982000_xaag083-B15","doi-asserted-by":"publisher","first-page":"1030222","DOI":"10.3389\/fimmu.2022.1030222","article-title":"Single-cell RNA sequencing reveals TCR(+) macrophages in HPV-related head and neck squamous cell carcinoma","volume":"13","author":"Jiang","year":"2022","journal-title":"Frontiers in Immunology"},{"key":"2026072801012982000_xaag083-B16","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nature Communications"},{"key":"2026072801012982000_xaag083-B17","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/s41586-018-0806-7","article-title":"Metabolic heterogeneity underlies reciprocal fates of T(H)17 cell stemness and plasticity","volume":"565","author":"Karmaus","year":"2019","journal-title":"Nature"},{"key":"2026072801012982000_xaag083-B18","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1016\/j.fertnstert.2013.12.049","article-title":"Enhanced follicular recruitment and atresia in cortex derived from ovaries with endometriomas","volume":"101","author":"Kitajima","year":"2014","journal-title":"Fertility and Sterility"},{"key":"2026072801012982000_xaag083-B19","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nature Methods"},{"key":"2026072801012982000_xaag083-B20","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18122673","article-title":"Expression profile of genes regulating steroid biosynthesis and metabolism in human ovarian granulosa cells-a primary culture approach","volume":"18","author":"Kranc","year":"2017","journal-title":"International Journal of Molecular Sciences"},{"key":"2026072801012982000_xaag083-B21","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s12958-015-0091-3","article-title":"Correlation of cumulus gene expression of GJA1, PRSS35, PTX3, and SERPINE2 with oocyte maturation, fertilization, and embryo development","volume":"13","author":"Li","year":"2015","journal-title":"Reproductive Biology and Endocrinology: RB&E"},{"key":"2026072801012982000_xaag083-B22","doi-asserted-by":"publisher","first-page":"110476","DOI":"10.1016\/j.biopha.2020.110476","article-title":"Possible involvement of crosstalk between endometrial cells and mast cells in the development of endometriosis via CCL8\/CCR1","volume":"129","author":"Li","year":"2020","journal-title":"Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie"},{"key":"2026072801012982000_xaag083-B23","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.fertnstert.2019.07.007","article-title":"Investigating the impact of local inflammation on granulosa cells and follicular development in women with ovarian endometriosis","volume":"112","author":"Li","year":"2019","journal-title":"Fertility and Sterility"},{"key":"2026072801012982000_xaag083-B24","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s13578-021-00637-x","article-title":"Single-cell transcriptomic analysis of endometriosis provides insights into fibroblast fates and immune cell heterogeneity","volume":"11","author":"Ma","year":"2021","journal-title":"Cell & Bioscience"},{"key":"2026072801012982000_xaag083-B25","doi-asserted-by":"publisher","first-page":"R455","DOI":"10.1530\/erc-16-0285","article-title":"Metabolic profiling of cholesterol and sex steroid hormones to monitor urological diseases","volume":"23","author":"Moon","year":"2016","journal-title":"Endocrine-Related Cancer"},{"key":"2026072801012982000_xaag083-B26","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12051858","article-title":"Expectant, medical, and surgical management of ovarian endometriomas","volume":"12","author":"Muzii","year":"2023","journal-title":"Journal of Clinical Medicine"},{"key":"2026072801012982000_xaag083-B27","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqab166","article-title":"LH induces de novo cholesterol biosynthesis via SREBP activation in granulosa cells during ovulation in female mice","volume":"162","author":"Nakanishi","year":"2021","journal-title":"Endocrinology"},{"key":"2026072801012982000_xaag083-B28","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.mce.2012.07.009","article-title":"Spatial differences within the membrana granulosa in the expression of focimatrix and steroidogenic capacity","volume":"363","author":"Nguyen","year":"2012","journal-title":"Molecular and Cellular Endocrinology"},{"key":"2026072801012982000_xaag083-B29","doi-asserted-by":"publisher","first-page":"E137","DOI":"10.1016\/j.fertnstert.2019.08.082","article-title":"Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries","volume":"112","author":"Nnoaham","year":"2019","journal-title":"Fertility and Sterility"},{"key":"2026072801012982000_xaag083-B30","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10071699","article-title":"Dissecting the miR-451a-Mif pathway in endometriosis pathophysiology using a syngeneic mouse model: temporal expression of lesion Mif receptors, Cd74 and Cxcr4","volume":"10","author":"Nothnick","year":"2022","journal-title":"Biomedicines"},{"key":"2026072801012982000_xaag083-B31","doi-asserted-by":"publisher","first-page":"6182","DOI":"10.1210\/jc.2019-00780","article-title":"Gene expression in granulosa cells from small antral follicles from women with or without polycystic ovaries","volume":"104","author":"Owens","year":"2019","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"2026072801012982000_xaag083-B32","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/j.rbmo.2020.09.002","article-title":"The follicular fluid metabolome differs according to the endometriosis phenotype","volume":"41","author":"Pocate-Cheriet","year":"2020","journal-title":"Reproductive Biomedicine Online"},{"key":"2026072801012982000_xaag083-B33","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1038\/nmeth.4402","article-title":"Reversed graph embedding resolves complex single-cell trajectories","volume":"14","author":"Qiu","year":"2017","journal-title":"Nature Methods"},{"key":"2026072801012982000_xaag083-B34","doi-asserted-by":"publisher","first-page":"2671","DOI":"10.1080\/15548627.2022.2046457","article-title":"Mitochondrial depolarization after acute ethanol treatment drives mitophagy in living mice","volume":"18","author":"Samuvel","year":"2022","journal-title":"Autophagy"},{"key":"2026072801012982000_xaag083-B35","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1093\/humrep\/det466","article-title":"Iron availability","volume":"29","author":"Sanchez","year":"2014","journal-title":"Human Reproduction (Oxford, England)"},{"key":"2026072801012982000_xaag083-B36","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.jsbmb.2015.07.023","article-title":"Endometriosis as a detrimental condition for granulosa cell steroidogenesis and development: From molecular alterations to clinical impact","volume":"155","author":"Sanchez","year":"2016","journal-title":"The Journal of Steroid Biochemistry and Molecular Biology"},{"key":"2026072801012982000_xaag083-B37","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1093\/humupd\/dmt053","article-title":"The distinguishing cellular and molecular features of the endometriotic ovarian cyst: from pathophysiology to the potential endometrioma-mediated damage to the ovary","volume":"20","author":"Sanchez","year":"2014","journal-title":"Human Reproduction Update"},{"key":"2026072801012982000_xaag083-B38","doi-asserted-by":"publisher","first-page":"19453","DOI":"10.1038\/s41598-020-76659-1","article-title":"Unveiling the heterogeneity of NKT cells in the liver through single cell RNA sequencing","volume":"10","author":"Shen","year":"2020","journal-title":"Scientific Reports"},{"key":"2026072801012982000_xaag083-B39","doi-asserted-by":"publisher","first-page":"3512","DOI":"10.7150\/thno.55241","article-title":"Ovarian hormones-autophagy-immunity axis in menstruation and endometriosis","volume":"11","author":"Shen","year":"2021","journal-title":"Theranostics"},{"key":"2026072801012982000_xaag083-B40","doi-asserted-by":"publisher","first-page":"200","DOI":"10.2174\/092986711794088416","article-title":"Role of natural killer cell activity in the pathogenesis of endometriosis","volume":"18","author":"Sikora","year":"2011","journal-title":"Current Medicinal Chemistry"},{"key":"2026072801012982000_xaag083-B41","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1016\/j.cell.2020.08.002","article-title":"Elevated calprotectin and abnormal myeloid cell subsets discriminate severe from mild COVID-19","volume":"182","author":"Silvin","year":"2020","journal-title":"Cell"},{"key":"2026072801012982000_xaag083-B7181934","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1007\/s00011-014-0762-0","article-title":"Complement protein C1q promotes macrophage anti-inflammatory M2-like polarization during the clearance of atherogenic lipoproteins","volume":"63","author":"Spivia","year":"2014","journal-title":"Inflammation Research"},{"key":"2026072801012982000_xaag083-B42","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.cell.2020.11.041","article-title":"Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma","volume":"184","author":"Sun","year":"2021","journal-title":"Cell"},{"key":"2026072801012982000_xaag083-B43","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1038\/s41556-022-00961-5","article-title":"Single-cell analysis of endometriosis reveals a coordinated transcriptional programme driving immunotolerance and angiogenesis across eutopic and ectopic tissues","volume":"24","author":"Tan","year":"2022","journal-title":"Nature Cell Biology"},{"key":"2026072801012982000_xaag083-B44","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/s0140-6736(21)00389-5","article-title":"Endometriosis is a chronic systemic disease: clinical challenges and novel innovations","volume":"397","author":"Taylor","year":"2021","journal-title":"Lancet (London, England)"},{"key":"2026072801012982000_xaag083-B45","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1186\/s12916-022-02359-4","article-title":"Deep immunophenotyping reveals endometriosis is marked by dysregulation of the mononuclear phagocytic system in endometrium and peripheral blood","volume":"20","author":"Vallv\u00e9-Juanico","year":"2022","journal-title":"BMC Medicine"},{"key":"2026072801012982000_xaag083-B46","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1093\/humupd\/dmz018","article-title":"The endometrial immune environment of women with endometriosis","volume":"25","author":"Vallv\u00e9-Juanico","year":"2019","journal-title":"Human Reproduction Update"},{"key":"2026072801012982000_xaag083-B47","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/nrendo.2013.255","article-title":"Endometriosis: pathogenesis and treatment","volume":"10","author":"Vercellini","year":"2014","journal-title":"Nature Reviews. Endocrinology"},{"key":"2026072801012982000_xaag083-B48","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17103641","article-title":"The impact of endometriosis on the quality of life and the incidence of depression-a cohort study","volume":"17","author":"Warzecha","year":"2020","journal-title":"International Journal of Environmental Research and Public Health"},{"key":"2026072801012982000_xaag083-B49","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1093\/humupd\/dmv007","article-title":"Gap junction connexins in female reproductive organs: implications for women\u2019s reproductive health","volume":"21","author":"Winterhager","year":"2015","journal-title":"Human Reproduction Update"},{"key":"2026072801012982000_xaag083-B50","doi-asserted-by":"publisher","DOI":"10.3390\/biom12020231","article-title":"Single-cell sequencing reveals an intrinsic heterogeneity of the preovulatory follicular microenvironment","volume":"12","author":"Wu","year":"2022","journal-title":"Biomolecules"},{"key":"2026072801012982000_xaag083-B51","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.freeradbiomed.2022.12.105","article-title":"Iron overload modulates follicular microenvironment via ROS\/HIF-1\u03b1\/FSHR signaling","volume":"196","author":"Wu","year":"2023","journal-title":"Free Radical Biology & Medicine"},{"key":"2026072801012982000_xaag083-B52","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1038\/s41590-020-0736-z","article-title":"Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection","volume":"21","author":"Xie","year":"2020","journal-title":"Nature Immunology"},{"key":"2026072801012982000_xaag083-B53","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1093\/humupd\/dmt024","article-title":"The role of the peritoneum in the pathogenesis of endometriosis","volume":"19","author":"Young","year":"2013","journal-title":"Human Reproduction Update"},{"key":"2026072801012982000_xaag083-B54","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1007\/s10815-024-03092-y","article-title":"Follicular fluid-derived exosomal LncRNA LIPE-AS1 modulates steroid metabolism and survival of granulosa cells leading to oocyte maturation arrest in polycystic ovary syndrome","volume":"41","author":"Yu","year":"2024","journal-title":"Journal of Assisted Reproduction and Genetics"}],"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/reproduction\/advance-article-pdf\/doi\/10.1093\/reprod\/xaag083\/68707429\/xaag083.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/172\/1\/xaag083\/68707429\/xaag083.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/172\/1\/xaag083\/68707429\/xaag083.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:01:40Z","timestamp":1785214900000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/doi\/10.1093\/reprod\/xaag083\/8726066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7,3]]}},"URL":"https:\/\/doi.org\/10.1093\/reprod\/xaag083","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7]]},"published":{"date-parts":[[2026,7]]},"article-number":"xaag083"}}