{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:49:34Z","timestamp":1792043374705,"version":"4.4.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Advances in oncology have significantly improved survival, particularly among children and adolescents with cancer. However, many anti-cancer treatments are gonadotoxic and pose a significant risk to future fertility with important psychosocial consequences for both patients and their families. Fertility preservation should therefore be addressed at diagnosis and prior to treatment initiation. Established strategies include embryo and mature oocyte preservation; however, these options are not feasible for pre-pubertal patients or for those requiring immediate chemotherapy. In such cases ovarian tissue cryopreservation with auto transplantation following remission represents the only available option. This approach can restore both endocrine and fertility. Once considered experimental, ovarian tissue cryopreservation is now considered an established technique, however, further optimization is required to improve efficacy and long-term outcomes, as well as to develop alternative strategies for utilizing tissue unsuitable for transplantation.<\/jats:p>","DOI":"10.1093\/reprod\/xaag123","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:48:57Z","timestamp":1791978537000},"source":"Crossref","is-referenced-by-count":0,"title":["Advances in Fertility Preservation for Women Undergoing Cancer Treatment: From Cryopreservation to Novel Therapies"],"prefix":"10.1093","author":[{"given":"R","family":"Antol\u00edn","sequence":"first","affiliation":[{"name":"University of Zaragoza Faculty of Medicine, , 50018 Zaragoza,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Gargallo-Alonso","sequence":"additional","affiliation":[{"name":"Institute for Health Research Arag\u00f3n (IIS Arag\u00f3n) , 50009 Zaragoza,","place":["Spain"]},{"name":"University of Zaragoza Tissue Microenvironment (TME) Lab, Arag\u00f3n Institute of Engineering Research (I3A), , 50018 Zaragoza,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Lacueva-Aparicio","sequence":"additional","affiliation":[{"name":"Institute for Health Research Arag\u00f3n (IIS Arag\u00f3n) , 50009 Zaragoza,","place":["Spain"]},{"name":"University of Zaragoza Tissue Microenvironment (TME) Lab, Arag\u00f3n Institute of Engineering Research (I3A), , 50018 Zaragoza,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E E","family":"Telfer","sequence":"additional","affiliation":[{"name":"University of Edinburgh Institute of Cell Biology, School of Biological Sciences, , Edinburgh,","place":["United Kingdom"]},{"name":"University of Edinburgh Centre for Reproductive Health, Institute of Regeneration and Repair, , Edinburgh,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Ochoa","sequence":"additional","affiliation":[{"name":"Institute for Health Research Arag\u00f3n (IIS Arag\u00f3n) , 50009 Zaragoza,","place":["Spain"]},{"name":"University of Zaragoza Tissue Microenvironment (TME) Lab, Arag\u00f3n Institute of Engineering Research (I3A), , 50018 Zaragoza,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN) , 28029 Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Malo","sequence":"additional","affiliation":[{"name":"Institute for Health Research Arag\u00f3n (IIS Arag\u00f3n) , 50009 Zaragoza,","place":["Spain"]},{"name":"University of Zaragoza Tissue Microenvironment (TME) Lab, Arag\u00f3n Institute of Engineering Research (I3A), , 50018 Zaragoza,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,14]]},"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/reproduction\/advance-article-pdf\/doi\/10.1093\/reprod\/xaag123\/71954799\/xaag123.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/advance-article-pdf\/doi\/10.1093\/reprod\/xaag123\/71954799\/xaag123.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:38:12Z","timestamp":1792042692000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/advance-article\/doi\/10.1093\/reprod\/xaag123\/8916735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,14]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/reprod\/xaag123","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,14]]},"article-number":"xaag123"}}