{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:49:13Z","timestamp":1787856553675,"version":"build-2784847793"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Frequent monitoring of forced vital capacity at home may be of added value in patients with SSc-associated interstitial lung disease (SSc-ILD) to monitor disease progression and guide treatment decisions. The aim of this study was to evaluate the feasibility and optimal frequency of online home spirometry using a home monitoring application in patients with SSc-ILD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a prospective, observational study in patients with SSc-ILD. Patients evaluated for 3\u2009months the online home monitoring application ILD-online integrated with a Bluetooth-connected spirometer. Patients performed daily home spirometry for 6\u2009weeks and weekly home spirometry for 6\u2009weeks. In addition, patients completed an evaluation questionnaire after 3\u2009months and online patient-reported outcomes at baseline and 3\u2009months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Ten consecutive patients participated. Mean adherence to home spirometry was 98.8% (s.d. 1.5). Home and hospital spirometry were highly correlated. The mean coefficient of variation was lower for weekly [2.45% (s.d. 1.19)] than daily [3.86% (s.d. 1.45)] forced vital capacity measurements (P\u2009=\u20090.005). All patients considered the home monitoring application and spirometer easy to use and no patients considered home spirometry burdensome. All patients would recommend home monitoring to other patients with SSc.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Home spirometry using an online home monitoring application is feasible in patients with SSc-ILD, with high adherence and patient satisfaction. Larger long-term studies are needed to assess whether home spirometry can detect the progression of ILD in patients with SSc.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/rheumatology\/keaa607","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T19:12:49Z","timestamp":1598382769000},"page":"2467-2471","source":"Crossref","is-referenced-by-count":34,"title":["Feasibility of online home spirometry in systemic sclerosis\u2013associated interstitial lung disease: a pilot study"],"prefix":"10.1093","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5295-2877","authenticated-orcid":false,"given":"Catharina C","family":"Moor","sequence":"first","affiliation":[{"name":"Department of Pulmonology, Erasmus Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander I","family":"van Leuven","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlies S","family":"Wijsenbeek","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Erasmus Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madelon C","family":"Vonk","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,19]]},"reference":[{"key":"2021051419010214500_keaa607-B1","doi-asserted-by":"crossref","first-page":"15002","DOI":"10.1038\/nrdp.2015.2","article-title":"Systemic sclerosis","volume":"1","author":"Allanore","year":"2015","journal-title":"Nat Rev Dis Primers"},{"key":"2021051419010214500_keaa607-B2","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/0002-9343(69)90044-8","article-title":"Pathologic observations in systemic sclerosis (scleroderma). A study of fifty-eight autopsy cases and fifty-eight matched controls","volume":"46","author":"D\u2019Angelo","year":"1969","journal-title":"Am J Med"},{"key":"2021051419010214500_keaa607-B3","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1378\/chest.54.6.490","article-title":"Pulmonary scleroderma","volume":"54","author":"Weaver","year":"1968","journal-title":"Dis Chest"},{"key":"2021051419010214500_keaa607-B4","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1183\/09059180.00005512","article-title":"Scleroderma lung disease","volume":"22","author":"Solomon","year":"2013","journal-title":"Eur Respir Rev"},{"key":"2021051419010214500_keaa607-B5","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1136\/ard.2006.062901","article-title":"Clinical risk assessment of organ manifestations in systemic sclerosis: a report from the EULAR Scleroderma Trials and Research group database","volume":"66","author":"Walker","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"2021051419010214500_keaa607-B6","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1136\/ard.2009.114264","article-title":"Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database","volume":"69","author":"Tyndall","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"2021051419010214500_keaa607-B7","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/S2213-2600(16)30152-7","article-title":"Mycophenolate mofetil versus oral cyclophosphamide in scleroderma-related interstitial lung disease (SLS II): a randomised controlled, double-blind, parallel group trial","volume":"4","author":"Tashkin","year":"2016","journal-title":"Lancet Respir Med"},{"key":"2021051419010214500_keaa607-B8","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1056\/NEJMoa1903076","article-title":"Nintedanib for systemic sclerosis-associated interstitial lung disease","volume":"380","author":"Distler","year":"2019","journal-title":"N Engl J Med"},{"key":"2021051419010214500_keaa607-B9","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/s41584-018-0062-0","article-title":"Major lung complications of systemic sclerosis","volume":"14","author":"Denton","year":"2018","journal-title":"Nat Rev Rheumatol"},{"key":"2021051419010214500_keaa607-B10","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1002\/art.39778","article-title":"Pulmonary function parameters other than vital capacity should be considered in screening for interstitial lung disease in patients with systemic sclerosis: comment on the article by Suliman et al","volume":"68","author":"Degano","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"2021051419010214500_keaa607-B11","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1002\/art.40130","article-title":"Short-term pulmonary function trends are predictive of mortality in interstitial lung disease associated with systemic sclerosis","volume":"69","author":"Goh","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"2021051419010214500_keaa607-B12","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12931-018-0810-3","article-title":"A home monitoring program including real-time wireless home spirometry in idiopathic pulmonary fibrosis: a pilot study on experiences and barriers","volume":"19","author":"Moor","year":"2018","journal-title":"Respir Res"},{"key":"2021051419010214500_keaa607-B13","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1164\/rccm.202002-0328OC","article-title":"Home monitoring in patients with idiopathic pulmonary fibrosis: a randomized controlled trial","volume":"202","author":"Moor","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"2021051419010214500_keaa607-B14","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3390\/jpm9020023","article-title":"Feasibility of a comprehensive home monitoring program for sarcoidosis","volume":"9","author":"Moor","year":"2019","journal-title":"J Pers Med"},{"key":"2021051419010214500_keaa607-B15","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1136\/annrheumdis-2013-204424","article-title":"2013 classification criteria for systemic sclerosis: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"72","author":"van den Hoogen","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"2021051419010214500_keaa607-B16","doi-asserted-by":"crossref","first-page":"00054","DOI":"10.1183\/23120541.00054-2020","article-title":"Diurnal variation in forced vital capacity in patients with fibrotic interstitial lung disease using home spirometry","volume":"6","author":"Moor","year":"2020","journal-title":"ERJ Open Res"},{"key":"2021051419010214500_keaa607-B17","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1136\/thoraxjnl-2012-201581","article-title":"The development and validation of the King\u2019s Brief Interstitial Lung Disease (K-BILD) health status questionnaire","volume":"67","author":"Patel","year":"2012","journal-title":"Thorax"},{"key":"2021051419010214500_keaa607-B18","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0168-8510(96)00822-6","article-title":"EuroQol: the current state of play","volume":"37","author":"Brooks","year":"1996","journal-title":"Health Policy"},{"key":"2021051419010214500_keaa607-B19","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr Scand"},{"key":"2021051419010214500_keaa607-B20","doi-asserted-by":"crossref","first-page":"1602406","DOI":"10.1183\/13993003.02406-2016","article-title":"Home monitoring improves endpoint efficiency in idiopathic pulmonary fibrosis","volume":"50","author":"Johannson","year":"2017","journal-title":"Eur Respir J"},{"key":"2021051419010214500_keaa607-B21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S2213-2600(19)30341-8","article-title":"Pirfenidone in patients with unclassifiable progressive fibrosing interstitial lung disease: a double-blind, randomised, placebo-controlled, phase 2 trial","volume":"8","author":"Maher","year":"2020","journal-title":"Lancet Respir Med"},{"key":"2021051419010214500_keaa607-B22","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1164\/rccm.201511-2152OC","article-title":"Daily home spirometry: an effective tool for detecting progression in idiopathic pulmonary fibrosis","volume":"194","author":"Russell","year":"2016","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/rheumatology\/article-pdf\/60\/5\/2467\/37935984\/keaa607.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/rheumatology\/article-pdf\/60\/5\/2467\/37935984\/keaa607.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T19:02:01Z","timestamp":1621018921000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/rheumatology\/article\/60\/5\/2467\/5992345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,19]]},"references-count":22,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,11,19]]},"published-print":{"date-parts":[[2021,5,14]]}},"URL":"https:\/\/doi.org\/10.1093\/rheumatology\/keaa607","relation":{},"ISSN":["1462-0324","1462-0332"],"issn-type":[{"value":"1462-0324","type":"print"},{"value":"1462-0332","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,5,1]]},"published":{"date-parts":[[2020,11,19]]}}}