{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T01:00:29Z","timestamp":1794013229811,"version":"4.8.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T00:00:00Z","timestamp":1609200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the reliability of the OMERACT paediatric ultrasound (US) synovitis definitions and scoring system in JIA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirteen sonographers analysed 75 images for the presence\/absence of elementary lesions (binary scoring) and for grading synovitis, synovial hypertrophy, effusion and Doppler signals. Static US images of the second metacarpophalangeal joint (MCP-II), wrist, elbow, knee and ankle in JIA patients at different ages and different disease stages were collected with standardized scanning by two experienced sonographers. Intra- and inter-reader reliability were analysed with kappa coefficients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Intra-reader reliability was good for binary scoring (Cohen\u2019s kappa 0.62, range 0.47\u20130.75), synovitis and synovial hypertrophy; excellent for Doppler signals (quadratic weighted kappa 0.77, 0.66\u20130.86; 0.76, 0.61\u20130.84; and 0.87, 0.77\u20130.94, respectively); and moderate for effusion (0.55, 0.24\u20130.76). Inter-reader reliability was good for synovitis and synovial hypertrophy (Light\u2019s kappa 0.68, 95% CI: 0.61, 0.75 and 0.63, 0.54\u20130.71, respectively), excellent for Doppler signals (0.85, 95% CI: 0.77, 0.90), and moderate for binary scoring and effusion (0.48, 95% CI: 0.36, 0.64 and 0.49, 0.40\u20130.60, respectively). We obtained the best scores for the knee (0.71, 0.54\u20130.85) except for Doppler signals, with reliability higher for MCP-II. We found a trend toward better results in older children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first study establishing the reliability of the OMERACT paediatric US synovitis definitions and scoring system in the five most commonly affected joints in JIA. The reliability was good among a large group of sonographers. These results support the applicability of these definitions and scoring system in clinical practice and multicentre studies.<\/jats:p><\/jats:sec>","DOI":"10.1093\/rheumatology\/keaa804","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T20:12:12Z","timestamp":1605298332000},"page":"3579-3587","source":"Crossref","is-referenced-by-count":34,"title":["Application of the OMERACT synovitis ultrasound scoring system in juvenile idiopathic arthritis: a multicenter reliability exercise"],"prefix":"10.1093","volume":"60","author":[{"given":"Linda","family":"Rossi-Semerano","sequence":"first","affiliation":[{"name":"Department of Pediatric Rheumatology, National Reference Centre for Auto-Inflammatory Diseases and Amyloidosis of Inflammatory origin (CEREMAIA), Bic\u00eatre Hospital, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Le Kremlin Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Breton","sequence":"additional","affiliation":[{"name":"Service de Radiologie P\u00e9diatrique, H\u00f4pital Necker Enfants Malades, AP-HP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Semerano","sequence":"additional","affiliation":[{"name":"Inserm UMR 1125, Sorbonne Paris Cit\u00e9, Universit\u00e9 Paris 13, Service de Rhumatologie, Groupe Hospitalier Avicenne\u2009-\u2009Jean-Verdier-Ren\u00e9-Muret, Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marouane","family":"Boubaya","sequence":"additional","affiliation":[{"name":"Clinical Research Unit and Clinical Research Center, Avicenne Hospital, AP-HP, Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haykanush","family":"Ohanyan","sequence":"additional","affiliation":[{"name":"Clinical Research Unit and Clinical Research Center, Avicenne Hospital, AP-HP, Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Bossert","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie H\u00f4pital Nord Franche Comt\u00e9, Tr\u00e9venans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorina","family":"Boiu","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Unit, Third Department of Pediatrics, National and Kapodistrian University of Athens, \u2018Attikon\u2019 General University Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Chatelus","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, H\u00f4pitaux Universitaires de Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raldine","family":"Durand","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, CHU de Poitiers, Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Jean","sequence":"additional","affiliation":[{"name":"Service de P\u00e9diatrie, CHR Rennes, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Goumy","sequence":"additional","affiliation":[{"name":"Service de P\u00e9diatrie, CHU de Angers, Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Mathiot","sequence":"additional","affiliation":[{"name":"Service de Radiologie p\u00e9diatrique, CHU de Bic\u00eatre, Le Kremlin Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00ebl","family":"Mouterde","sequence":"additional","affiliation":[{"name":"Rheumatology Department, CHU Montpellier, Montpellier University, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Nugues","sequence":"additional","affiliation":[{"name":"Clinique Universitaire d'Imagerie P\u00e9diatrique - 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