{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:39:08Z","timestamp":1791589148986,"version":"4.3.4"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071830"],"award-info":[{"award-number":["82071830"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008750","name":"Shanghai Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC22020CR1013"],"award-info":[{"award-number":["SHDC22020CR1013"]}],"id":[{"id":"10.13039\/501100008750","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["20204Y0428B"],"award-info":[{"award-number":["20204Y0428B"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010120","name":"Huashan Hospital","doi-asserted-by":"publisher","award":["2020QD006"],"award-info":[{"award-number":["2020QD006"]}],"id":[{"id":"10.13039\/501100010120","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Pujiang Young Rheumatologists Training Program","award":["SPROG2106"],"award-info":[{"award-number":["SPROG2106"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Spontaneous serum uric acid (SUA) decrease has been found in many patients during acute gout attacks, but its mechanism remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The spontaneous regulation of SUA during a gout attack and its possible causes were evaluated in patients with gout. The mechanism of the spontaneous SUA decrease was further studied in Caco2 cells and a monosodium urate (MSU)-induced gout model of wild-type mice and ABCG2\u2212\/\u2212 mice. The urate transport function of intestinal epithelial cells was detected by transwell culture of Caco2 cells. Expression of ATP-binding cassette super-family G member 2 (ABCG2), IL-1\u03b2 and phosphoinositide 3-kinase (PI3K)\/Akt was analysed using real-time PCR, western blotting, or immunofluorescence assays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SUA decreased during acute gout attacks in both the gout patients and MSU-induced gouty mice. Increased serum CRP and IL-1\u03b2 levels were correlated with the SUA decrease. Intestinal uric acid excretion and expression of ABCG2 were upregulated in the mice during acute gout attacks. In the ABCG2\u2212\/\u2212 mice, intestinal uric acid excretion significantly decreased during gout attacks. In an in vitro study of a transwell culture, ABCG2 and its upstream PI3K\/Akt pathway were significantly upregulated in intestinal epithelial cells. However, ABCG2 expression and its associated intestinal uric acid transport were inhibited when PI3K\/Akt was blocked by a PI3K inhibitor, LY294002.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Increased intestinal urate excretion resulted in spontaneous SUA downregulation during acute gout attacks. Inflammation-induced PI3K\/Akt activation and ABCG2 expression in epithelial cells might contribute to the upregulation of intestinal uric acid excretion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/rheumatology\/kead139","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T09:23:52Z","timestamp":1681291432000},"page":"3984-3992","source":"Crossref","is-referenced-by-count":25,"title":["Intestinal uric acid excretion contributes to serum uric acid decrease during acute gout attack"],"prefix":"10.1093","volume":"62","author":[{"given":"Tianyi","family":"Zhao","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Huashan Hospital, Fudan University , Shanghai, China"},{"name":"Institute of Rheumatology, Immunology and Allergy, Fudan University , Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Cao","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Huashan 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