{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T08:53:35Z","timestamp":1794560015083,"version":"4.9.1"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Group for Research and Assessment of Psoriasis and Psoriatic Arthritis"},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG034676"],"award-info":[{"award-number":["R01AG034676"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1 TR002377"],"award-info":[{"award-number":["UL1 TR002377"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Rheumatology Research Foundation Scientist Development"},{"name":"Group for Research and Assessment of Psoriasis and Psoriatic Arthritis"},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["1K23AR082990-01"],"award-info":[{"award-number":["1K23AR082990-01"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Rheumatology Research Foundation Scientist Development"},{"name":"Center for the Science of Health Care Delivery"},{"name":"Women\u2019s Health Career Enhancement"},{"name":"Eaton Family Career Development"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To examine multimorbidity in psoriasis and its association with the development of psoriatic arthritis (PsA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective cohort study was performed using the Rochester Epidemiology Project. Population-based incidence (2000\u201309) and prevalence (1 January 2010) cohorts of psoriasis were identified by manual chart review. A cohort of individuals without psoriasis (comparators) were identified (1:1 matched on age, sex and county). Morbidities were defined using two or more Clinical Classification Software codes \u226530\u2009days apart within prior 5\u2009years. PsA was defined using ClASsification of Psoriatic ARthritis (CASPAR) criteria. \u03c72 and rank-sum tests were used to compare morbidities, and age-, sex- and race-adjusted Cox models to examine the association of baseline morbidities in psoriasis with development of PsA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 817 incident psoriasis patients, the mean age was 45.2\u2009years with 52.0% females, and 82.0% moderate\/severe psoriasis. No multimorbidity differences were found between incident psoriasis patients and comparators. However, in the 1088 prevalent psoriasis patients, multimorbidity was significantly more common compared with 1086 comparators (odds ratio 1.35 and 1.48 for two or more and five or more morbidities, respectively). Over a median 13.3-year follow-up, 23 patients (cumulative incidence: 2.9% by 15\u2009years) developed PsA. Multimorbidity (two or more morbidities) was associated with a 3-fold higher risk of developing PsA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Multimorbidity was more common in the prevalent but not incident cohort of psoriasis compared with the general population, suggesting that patients with psoriasis may experience accelerated development of multimorbidity. Moreover, multimorbidity at psoriasis onset significantly increased the risk of developing PsA, highlighting the importance of monitoring multimorbid psoriasis patients for the development of PsA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/rheumatology\/keae040","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T08:09:58Z","timestamp":1706688598000},"page":"2199-2203","source":"Crossref","is-referenced-by-count":6,"title":["Multimorbidity in psoriasis as a risk factor for psoriatic arthritis: a population-based study"],"prefix":"10.1093","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1034-1530","authenticated-orcid":false,"given":"Paras","family":"Karmacharya","sequence":"first","affiliation":[{"name":"Division of Rheumatology & Immunology, Vanderbilt University Medical Center , Nashville, TN,","place":["USA"]},{"name":"Division of Rheumatology, Mayo Clinic , Rochester, MN,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikesh","family":"Chakradhar","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Mayo Clinic , Rochester, MN,","place":["USA"]},{"name":"Department of Psychiatry, MetroHealth Medical Center , Psychiatry, Cleveland, OH,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassondra A","family":"Hulshizer","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Mayo Clinic , Rochester, MN,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina M","family":"Gunderson","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Mayo Clinic , Rochester, MN,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4639-0775","authenticated-orcid":false,"given":"Alexis","family":"Ogdie","sequence":"additional","affiliation":[{"name":"Departments of Medicine\/Rheumatology and Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M","family":"Davis III","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Mayo Clinic , Rochester, MN,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"Wright","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Mayo Clinic , Rochester, MN,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megha M","family":"Tollefson","sequence":"additional","affiliation":[{"name":"Departments of Dermatology and Pediatric and Adolescent Medicine, Mayo Clinic , Rochester, MN,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1749-5719","authenticated-orcid":false,"given":"Al\u00ed","family":"Duarte-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Mayo Clinic , Rochester, MN,","place":["USA"]},{"name":"Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic , Rochester, MN,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1907-0864","authenticated-orcid":false,"given":"Delamo","family":"Bekele","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Mayo Clinic , Rochester, MN,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilal","family":"Maradit-Kremers","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Mayo Clinic , Rochester, MN,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5847-7475","authenticated-orcid":false,"given":"Cynthia S","family":"Crowson","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Mayo Clinic , Rochester, MN,","place":["USA"]},{"name":"Department of Quantitative Health Sciences, Mayo Clinic , Rochester, 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