{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:49:11Z","timestamp":1789148951745,"version":"build-2803163510"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"National Key Research and Development Plan of China","award":["2022YFC3601900"],"award-info":[{"award-number":["2022YFC3601900"]}]},{"name":"National Key Research and Development Plan of China","award":["2022YFC2505500"],"award-info":[{"award-number":["2022YFC2505500"]}]},{"name":"Scientific Research Program of FuRong Laboratory","award":["2023SK2100"],"award-info":[{"award-number":["2023SK2100"]}]},{"name":"Scientific Research Program of FuRong Laboratory","award":["2024PT5108"],"award-info":[{"award-number":["2024PT5108"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,4]]},"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n Genetic predisposition increases the risk of gout, while walking activity may reduce it. We evaluated whether genetic predisposition modifies the association between walking activity and gout risk.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We included gout-free participants aged 40\u201370\u2009years from the UK Biobank. Polygenic risk scores (PRS) were calculated using gout-associated single nucleotide polymorphisms, and participants were stratified into three strata according to PRS tertiles. Walking activity data were obtained from 7-day accelerometer recordings. Hazard ratios (HRs), risk differences (RDs) and 95% CIs for incident gout were estimated for moderate and high walking activity levels compared with the low activity within each PRS stratum.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Among 86\u2009930 participants (mean age: 61.9\u2009years; 57.3% women), 672 developed gout over a 7-year follow-up. In the high PRS stratum, participants with moderate and high walking volumes had significantly lower rates of incident gout than those with low walking volumes, with HRs (95% CIs) of 0.68 (0.53, 0.87) and 0.55 (0.40, 0.75), respectively. The corresponding 7-year RDs (95% CIs) were \u20130.64% (\u20131.00%, \u20130.27%) and \u20130.81% (\u20131.18%, \u20130.45%). Similar inverse associations were observed in the moderate and low PRS strata. Additionally, higher walking intensity was associated with reduced gout risk across all PRS strata, with the protective effect being more pronounced in the high PRS stratum (P for additive interaction = 0.05).<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Higher walking activity was associated with a lower risk of gout across all levels of genetic predisposition, with the strongest effects observed in individuals with high genetic susceptibility.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/rheumatology\/keaf690","type":"journal-article","created":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T12:46:58Z","timestamp":1766666818000},"source":"Crossref","is-referenced-by-count":2,"title":["Genetic susceptibility, walking activity and the risk of incident gout"],"prefix":"10.1093","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5127-5253","authenticated-orcid":false,"given":"Ziying","family":"Wu","sequence":"first","affiliation":[{"name":"Department of 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Changsha,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7638-0888","authenticated-orcid":false,"given":"Yuqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School , Boston, MA,","place":["USA"]},{"name":"The Mongan Institute, Massachusetts General Hospital, Harvard Medical School , Boston, MA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5883-5399","authenticated-orcid":false,"given":"Hongyi","family":"He","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Xiangya Hospital Central South University , Changsha,","place":["China"]},{"name":"Bioinformatics Center, Xiangya Hospital Central South University , 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Changsha,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2987-138X","authenticated-orcid":false,"given":"Guanghua","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Xiangya Hospital Central South University , Changsha,","place":["China"]},{"name":"Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Central South University , Changsha,","place":["China"]},{"name":"Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital Central South University , Changsha,","place":["China"]},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University , Changsha,","place":["China"]},{"name":"FuRong Laboratory , Changsha,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3510-8241","authenticated-orcid":false,"given":"Jie","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Xiangya Hospital Central South University , Changsha,","place":["China"]},{"name":"Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Central South University , Changsha,","place":["China"]},{"name":"Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital Central South University , Changsha,","place":["China"]},{"name":"Department of Epidemiology and Health Statistics, Central South University Xiangya School of Public Health , Changsha,","place":["China"]},{"name":"FuRong Laboratory , 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