{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T11:11:23Z","timestamp":1793272283901,"version":"4.5.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T00:00:00Z","timestamp":1522195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council, UK","doi-asserted-by":"crossref","award":["G0800629"],"award-info":[{"award-number":["G0800629"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,1]]},"DOI":"10.1093\/rheumatology\/key063","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T15:15:25Z","timestamp":1519398925000},"page":"1222-1227","source":"Crossref","is-referenced-by-count":31,"title":["B-cell activity markers are associated with different disease activity domains in primary Sj\u00f6gren\u2019s syndrome"],"prefix":"10.1093","volume":"57","author":[{"given":"Katherine","family":"James","sequence":"first","affiliation":[{"name":"Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle, UK"},{"name":"Interdisciplinary Computing and Complex BioSystems (ICOS) Research Group, Newcastle University, Newcastle, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chimwemwe","family":"Chipeta","sequence":"additional","affiliation":[{"name":"Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony","family":"Parker","sequence":"additional","affiliation":[{"name":"Department of Clinical R&D, The Binding Site Group Ltd, Edgbaston, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Harding","sequence":"additional","affiliation":[{"name":"Department of Clinical R&D, The Binding Site Group Ltd, Edgbaston, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J","family":"Cockell","sequence":"additional","affiliation":[{"name":"Bioinformatics Support Unit, Newcastle University, Newcastle, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin S","family":"Gillespie","sequence":"additional","affiliation":[{"name":"School of Mathematics & Statistics, Newcastle University, Newcastle, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Hallinan","sequence":"additional","affiliation":[{"name":"Interdisciplinary Computing and Complex BioSystems (ICOS) Research Group, Newcastle University, Newcastle, UK"},{"name":"Department of Biological Sciences, Macquarie University, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Barone","sequence":"additional","affiliation":[{"name":"Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J","family":"Bowman","sequence":"additional","affiliation":[{"name":"Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK"},{"name":"Rheumatology Department, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Fai","family":"Ng","sequence":"additional","affiliation":[{"name":"Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4631-549X","authenticated-orcid":false,"given":"Benjamin A","family":"Fisher","sequence":"additional","affiliation":[{"name":"Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK"},{"name":"Rheumatology Department, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"UK Primary Sj\u00f6gren\u2019s Syndrome Registry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,3,28]]},"reference":[{"key":"key\n\t\t\t\t20180622035839_key063-B1","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1136\/annrheumdis-2012-202293","article-title":"Efficacy of rituximab in systemic manifestations of primary Sjogren's syndrome: results in 78 patients of the AutoImmune and Rituximab registry","volume":"72","author":"Gottenberg","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"key\n\t\t\t\t20180622035839_key063-B2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1172\/JCI0214121","article-title":"Association of BAFF\/BLyS overexpression and altered B cell differentiation with Sj\u00f6gren's syndrome","volume":"109","author":"Groom","year":"2002","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20180622035839_key063-B3","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1136\/ard.2009.110619","article-title":"EULAR Sjogren's syndrome disease activity index: development of a consensus systemic disease activity index for primary Sjogren's syndrome","volume":"69","author":"Seror","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"key\n\t\t\t\t20180622035839_key063-B4","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1136\/annrheumdis-2015-208504","article-title":"Development of the ClinESSDAI: a clinical score without biological domain. A tool for biological studies","volume":"75","author":"Seror","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"key\n\t\t\t\t20180622035839_key063-B5","first-page":"544","article-title":"Eligibility for clinical trials in primary Sjogren's syndrome: lessons from the UK Primary Sj\u00f6gren's Syndrome Registry","volume":"55","author":"Oni","year":"2016","journal-title":"Rheumatology"},{"key":"key\n\t\t\t\t20180622035839_key063-B6","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1136\/annrheumdis-2015-207499","article-title":"A review of salivary gland histopathology in primary Sj\u00f6gren's syndrome with a focus on its potential as a clinical trials biomarker","volume":"74","author":"Fisher","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"key\n\t\t\t\t20180622035839_key063-B7","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1136\/annrheumdis-2016-210448","article-title":"Standardisation of labial salivary gland histopathology in clinical trials in primary Sj\u00f6gren's syndrome","volume":"76","author":"Fisher","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"key\n\t\t\t\t20180622035839_key063-B8","doi-asserted-by":"crossref","first-page":"e000364","DOI":"10.1136\/rmdopen-2016-000364","article-title":"Salivary gland ultrasound abnormalities in primary Sj\u00f6gren's syndrome: consensual US-SG core items definition and reliability","volume":"3","author":"Jousse-Joulin","year":"2017","journal-title":"RMD Open"},{"key":"key\n\t\t\t\t20180622035839_key063-B9","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1136\/annrheumdis-2017-212268","article-title":"Effect of rituximab on a salivary gland ultrasound score in primary Sjogren's syndrome: results of the TRACTISS randomised double-blind multicentre substudy","volume":"77","author":"Fisher","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"key\n\t\t\t\t20180622035839_key063-B10","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s13075-016-1006-1","article-title":"Identification of definitive serum biomarkers associated with disease activity in primary Sj\u00f6gren's syndrome","volume":"18","author":"Nishikawa","year":"2016","journal-title":"Arthritis Res Therapy"},{"key":"key\n\t\t\t\t20180622035839_key063-B11","doi-asserted-by":"crossref","first-page":"e59868","DOI":"10.1371\/journal.pone.0059868","article-title":"Serum levels of beta2-microglobulin and free light chains of immunoglobulins are associated with systemic disease activity in primary Sj\u00f6gren's syndrome. Data at enrollment in the prospective ASSESS cohort","volume":"8","author":"Gottenberg","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180622035839_key063-B12","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1136\/ard.2011.153098","article-title":"Serum \u03b22 microglobulin correlates with the new ESSDAI in patients with Sj\u00f6gren's syndrome","volume":"70","author":"Pertovaara","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"key\n\t\t\t\t20180622035839_key063-B13","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.cca.2011.03.007","article-title":"Free immunoglobulin light chain: its biology and implications in diseases","volume":"412","author":"Nakano","year":"2011","journal-title":"Clin Chim Acta"},{"key":"key\n\t\t\t\t20180622035839_key063-B14","doi-asserted-by":"crossref","first-page":"e000022","DOI":"10.1136\/rmdopen-2014-000022","article-title":"EULAR Sj\u00f6gren's syndrome disease activity index (ESSDAI): a user guide","volume":"1","author":"Seror","year":"2015","journal-title":"RMD Open"},{"key":"key\n\t\t\t\t20180622035839_key063-B15","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.1002\/art.39315","article-title":"CXCL13 and CCL11 serum levels and lymphoma and disease activity in primary Sj\u00f6gren's syndrome","volume":"67","author":"Nocturne","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"key\n\t\t\t\t20180622035839_key063-B16","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/rheumatology\/kes180","article-title":"BLyS upregulation in Sjogren's syndrome associated with lymphoproliferative disorders, higher ESSDAI score and B-cell clonal expansion in the salivary glands","volume":"52","author":"Quartuccio","year":"2013","journal-title":"Rheumatology"},{"key":"key\n\t\t\t\t20180622035839_key063-B17","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jneuroim.2013.01.001","article-title":"Intravenous immunoglobulin inhibits BAFF production in chronic inflammatory demyelinating polyneuropathy - a new mechanism of action?","volume":"256","author":"Bick","year":"2013","journal-title":"J Neuroimmunol"},{"key":"key\n\t\t\t\t20180622035839_key063-B18","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jneuroim.2014.06.007","article-title":"IVIG regulates BAFF expression in patients with chronic inflammatory demyelinating polyneuropathy (CIDP)","volume":"274","author":"Ritter","year":"2014","journal-title":"J Neuroimmunol"},{"key":"key\n\t\t\t\t20180622035839_key063-B19","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1136\/jnnp-2017-315878","article-title":"Lymphocyte antigens targetable by monoclonal antibodies in non-systemic vasculitic neuropathy","volume":"88","author":"Schneider","year":"2017","journal-title":"J Neurol Neurosurgery Psychiatry"},{"key":"key\n\t\t\t\t20180622035839_key063-B20","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/nrneph.2015.174","article-title":"Renal involvement in primary Sj\u00f6gren syndrome","volume":"12","author":"Fran\u00e7ois","year":"2016","journal-title":"Nat Rev Nephrol"},{"key":"key\n\t\t\t\t20180622035839_key063-B21","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.autrev.2016.01.008","article-title":"Secreted autoantibody repertoires in Sj\u00f6gren's syndrome and systemic lupus erythematosus: a proteomic approach","volume":"15","author":"Al Kindi","year":"2016","journal-title":"Autoimmun Rev"}],"container-title":["Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/rheumatology\/article-pdf\/57\/7\/1222\/25068739\/key063.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T15:02:32Z","timestamp":1570806152000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/rheumatology\/article\/57\/7\/1222\/4955850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,28]]},"references-count":21,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,3,28]]},"published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/rheumatology\/key063","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.732962337.793564238","asserted-by":"object"}]},"ISSN":["1462-0324","1462-0332"],"issn-type":[{"value":"1462-0324","type":"print"},{"value":"1462-0332","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,7]]},"published":{"date-parts":[[2018,3,28]]}}}