{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:30:55Z","timestamp":1791412255080,"version":"4.3.3"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T00:00:00Z","timestamp":1534896000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Vidi-grant"},{"DOI":"10.13039\/501100003246","name":"Netherlands Organisation for Scientific Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union\u2019s Horizon 2020 research","award":["714312"],"award-info":[{"award-number":["714312"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"DOI":"10.1093\/rheumatology\/key220","type":"journal-article","created":{"date-parts":[[2018,7,14]],"date-time":"2018-07-14T11:45:35Z","timestamp":1531568735000},"page":"86-93","source":"Crossref","is-referenced-by-count":21,"title":["Is joint pain in patients with arthralgia suspicious for progression to rheumatoid arthritis explained by subclinical inflammation? A cross-sectional MRI study"],"prefix":"10.1093","volume":"58","author":[{"given":"Leonie E","family":"Burgers","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin M","family":"ten Brinck","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette H M","family":"van der Helm-van Mil","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands"},{"name":"Department of Rheumatology, Erasmus Medical Centre, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,8,21]]},"reference":[{"key":"key\n\t\t\t\t2018121406542160500_key220-B1","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1136\/annrheumdis-2011-200990","article-title":"EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: report from the Study Group for Risk Factors for Rheumatoid Arthritis","volume":"71","author":"Gerlag","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B2","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1002\/art.27692","article-title":"Long-term impact of delay in assessment of patients with early arthritis","volume":"62","author":"van der Linden","year":"2010","journal-title":"Arthritis Rheum"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B3","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1136\/annrheumdis-2014-206047","article-title":"Evaluating relationships between symptom duration and persistence of rheumatoid arthritis: does a window of opportunity exist? Results on the Leiden Early Arthritis Clinic and ESPOIR cohorts","volume":"74","author":"van Nies","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B4","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1002\/art.24661","article-title":"Prevalence of and predictive factors for sustained disease-modifying antirheumatic drug-free remission in rheumatoid arthritis: results from two large early arthritis cohorts","volume":"60","author":"van der Woude","year":"2009","journal-title":"Arthritis Rheum"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B5","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.berh.2013.09.002","article-title":"Can rheumatoid arthritis be prevented?","volume":"27","author":"Deane","year":"2013","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B6","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nrrheum.2017.185","article-title":"Preventing progression from arthralgia to arthritis: targeting the right patients","volume":"14","author":"van Steenbergen","year":"2017","journal-title":"Nat Rev Rheumatol"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B7","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1136\/annrheumdis-2016-209846","article-title":"EULAR definition of arthralgia suspicious for progression to rheumatoid arthritis","volume":"76","author":"van Steenbergen","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B8","doi-asserted-by":"crossref","first-page":"e000419","DOI":"10.1136\/rmdopen-2016-000419","article-title":"Functional limitations in the phase of clinically suspect arthralgia are as serious as in early clinical arthritis; a longitudinal study","volume":"3","author":"ten Brinck","year":"2017","journal-title":"RMD Open"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.berh.2017.09.016","article-title":"Symptoms in individuals at risk of rheumatoid arthritis","volume":"31","author":"Jutley","year":"2017","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B10","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1136\/annrheumdis-2012-202628","article-title":"MRI of hand and foot joints of patients with anticitrullinated peptide antibody positive arthralgia without clinical arthritis","volume":"72","author":"Krabben","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B11","doi-asserted-by":"crossref","first-page":"R92","DOI":"10.1186\/ar4536","article-title":"Subclinical inflammation on MRI of hand and foot of anticitrullinated peptide antibody\u2013negative arthralgia patients at risk for rheumatoid arthritis","volume":"16","author":"van Steenbergen","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B12","doi-asserted-by":"crossref","first-page":"R98","DOI":"10.1186\/ar3028","article-title":"The value of ultrasonography in predicting arthritis in auto-antibody positive arthralgia patients: a prospective cohort study","volume":"12","author":"van de Stadt","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B13","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1136\/ard.2009.126821","article-title":"A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis","volume":"70","author":"Padyukov","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B14","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/art.21575","article-title":"A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA\u2013DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination","volume":"54","author":"Klareskog","year":"2006","journal-title":"Arthritis Rheum"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B15","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1136\/annrheumdis-2017-211325","article-title":"Differences in the symptomatic phase preceding ACPA-positive and ACPA-negative RA: a longitudinal study in arthralgia during progression to clinical arthritis","volume":"76","author":"Burgers","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B16","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1136\/annrheumdis-2014-205522","article-title":"Characterising arthralgia in the preclinical phase of rheumatoid arthritis using MRI","volume":"74","author":"van Steenbergen","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B17","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1093\/rheumatology\/kex324","article-title":"Validation of the EULAR definition of arthralgia suspicious for progression to rheumatoid arthritis","volume":"56","author":"Burgers","year":"2017","journal-title":"Rheumatology (Oxford)"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B18","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1002\/art.39550","article-title":"The course of bone marrow edema in early undifferentiated and rheumatoid arthritis: a longitudinal MRI study on bone level","volume":"68","author":"Nieuwenhuis","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B19","doi-asserted-by":"crossref","first-page":"i3","DOI":"10.1136\/ard.2004.031773","article-title":"An introduction to the EULAR\u2013OMERACT rheumatoid arthritis MRI reference image atlas","volume":"64(Suppl 1)","author":"\u00d8stergaard","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B20","first-page":"1385","article-title":"OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging Studies. Core set of MRI acquisitions, joint pathology definitions, and the OMERACT RA-MRI scoring system","volume":"30","author":"\u00d8stergaard","year":"2003","journal-title":"J Rheumatol"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B21","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.3899\/jrheum.100906","article-title":"Magnetic resonance imaging of the rheumatic foot according to the RAMRIS system is reliable","volume":"38","author":"Baan","year":"2011","journal-title":"J Rheumatol"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B22","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1136\/ard.2006.068361","article-title":"Introduction of a novel magnetic resonance imaging tenosynovitis score for rheumatoid arthritis: reliability in a multireader longitudinal study","volume":"66","author":"Haavardsholm","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B23","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1136\/annrheumdis-2013-204005","article-title":"Concordance between inflammation at physical examination and on MRI in patients with early arthritis","volume":"74","author":"Krabben","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B24","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/ar4035","article-title":"Bone marrow edema and osteitis in rheumatoid arthritis: the imaging perspective","volume":"14","author":"McQueen","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B25","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1136\/ard.2008.088245","article-title":"MRI bone oedema is the strongest predictor of subsequent radiographic progression in early rheumatoid arthritis. Results from a 2-year randomised controlled trial (CIMESTRA)","volume":"68","author":"Hetland","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B26","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1136\/annrheumdis-2014-205208","article-title":"MRI-detected subclinical joint inflammation is associated with radiographic progression","volume":"73","author":"Krabben","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B27","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1136\/ard.2008.096024","article-title":"Cellular characterisation of magnetic resonance imaging bone oedema in rheumatoid arthritis;implications for pathogenesis of erosive disease","volume":"68","author":"Dalbeth","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B28","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1136\/annrheumdis-2015-208094","article-title":"Autoantibodies to citrullinated proteins induce joint pain independent of inflammation via a chemokine-dependent mechanism","volume":"75","author":"Wigerblad","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B29","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/art.23148","article-title":"Differences in synovial tissue infiltrates between anti-cyclic citrullinated peptide-positive rheumatoid arthritis and anti-cyclic citrullinated peptide-negative rheumatoid arthritis","volume":"58","author":"van Oosterhout","year":"2008","journal-title":"Arthritis Rheum"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B30","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1002\/art.39749","article-title":"MR-detected features of inflammation and erosions occur in symptom-free persons from the general population","volume":"68","author":"Mangnus","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B31","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1093\/rheumatology\/kex235","article-title":"Using a reference when defining an abnormal MRI reduces false-positive MRI results\u2014a longitudinal study in two cohorts at risk for rheumatoid arthritis","volume":"56","author":"Boer","year":"2017","journal-title":"Rheumatology (Oxford)"},{"key":"key\n\t\t\t\t2018121406542160500_key220-B32","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.3899\/jrheum.161433","article-title":"The OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging (MRI) Scoring System: updated recommendations by the OMERACT MRI in Arthritis Working Group","volume":"44","author":"\u00d8stergaard","year":"2017","journal-title":"J Rheumatol"}],"container-title":["Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/rheumatology\/article-pdf\/58\/1\/86\/27145449\/key220.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T07:26:11Z","timestamp":1720423571000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/rheumatology\/article\/58\/1\/86\/5077387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,21]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,8,21]]},"published-print":{"date-parts":[[2019,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/rheumatology\/key220","relation":{},"ISSN":["1462-0324","1462-0332"],"issn-type":[{"value":"1462-0324","type":"print"},{"value":"1462-0332","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,1]]},"published":{"date-parts":[[2018,8,21]]}}}