{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:55:00Z","timestamp":1791618900205,"version":"4.3.4"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T00:00:00Z","timestamp":1533513600000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,12,1]]},"DOI":"10.1093\/rheumatology\/key229","type":"journal-article","created":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T21:21:05Z","timestamp":1530825665000},"page":"2145-2148","source":"Crossref","is-referenced-by-count":88,"title":["Genetic association between adiposity and gout: a Mendelian randomization study"],"prefix":"10.1093","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0118-0341","authenticated-orcid":false,"given":"Susanna C","family":"Larsson","sequence":"first","affiliation":[{"name":"Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Burgess","sequence":"additional","affiliation":[{"name":"MRC Biostatistics Unit, University of Cambridge, Cambridge, UK"},{"name":"Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Micha\u00eblsson","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Uppsala University, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,8,4]]},"reference":[{"key":"key\n\t\t\t\t2018112705033865600_key229-B1","first-page":"2039","article-title":"Gout","volume":"388","author":"Dalbeth","year":"2016","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2018112705033865600_key229-B2","first-page":"335","article-title":"Increased cardiovascular mortality associated with gout: a systematic review and meta-analysis","volume":"22","author":"Clarson","year":"2015","journal-title":"Eur J Prev Cardiol"},{"key":"key\n\t\t\t\t2018112705033865600_key229-B3","first-page":"155","article-title":"Epidemiology of gout","volume":"40","author":"Roddy","year":"2014","journal-title":"Rheum Dis Clin North Am"},{"key":"key\n\t\t\t\t2018112705033865600_key229-B4","first-page":"649","article-title":"Global epidemiology of gout: prevalence, incidence and risk factors","volume":"11","author":"Kuo","year":"2015","journal-title":"Nat Rev Rheumatol"},{"key":"key\n\t\t\t\t2018112705033865600_key229-B5","first-page":"661","article-title":"Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study","volume":"74","author":"Kuo","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"key\n\t\t\t\t2018112705033865600_key229-B6","first-page":"13","article-title":"Health effects of overweight and obesity in 195 countries over 25 years","volume":"377","author":"Afshin","year":"2017","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2018112705033865600_key229-B7","first-page":"1591","article-title":"Body mass index and the risk of gout: a systematic review and dose-response meta-analysis of prospective studies","volume":"53","author":"Aune","year":"2014","journal-title":"Eur J Nutr"},{"key":"key\n\t\t\t\t2018112705033865600_key229-B8","first-page":"1870","article-title":"Weight loss for overweight and obese individuals with gout: a systematic review of longitudinal studies","volume":"76","author":"Nielsen","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"key\n\t\t\t\t2018112705033865600_key229-B9","first-page":"j1794","article-title":"The Dietary Approaches to Stop Hypertension (DASH) diet, Western diet, and risk of gout in men: prospective cohort study","volume":"357","author":"Rai","year":"2017","journal-title":"BMJ"},{"key":"key\n\t\t\t\t2018112705033865600_key229-B10","first-page":"1","article-title":"\u2018Mendelian randomization\u2019: can genetic epidemiology contribute to understanding environmental determinants of disease?","volume":"32","author":"Smith","year":"2003","journal-title":"Int J Epidemiol"},{"key":"key\n\t\t\t\t2018112705033865600_key229-B11","first-page":"197","article-title":"Genetic studies of body mass index yield new insights for obesity biology","volume":"518","author":"Locke","year":"2015","journal-title":"Nature"},{"key":"key\n\t\t\t\t2018112705033865600_key229-B12","first-page":"187","article-title":"New genetic loci link adipose and insulin biology to body fat distribution","volume":"518","author":"Shungin","year":"2015","journal-title":"Nature"},{"key":"key\n\t\t\t\t2018112705033865600_key229-B13","first-page":"145","article-title":"Genome-wide association analyses identify 18 new loci associated with serum urate concentrations","volume":"45","author":"K\u00f6ttgen","year":"2013","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t2018112705033865600_key229-B14","first-page":"30","article-title":"Sensitivity analyses for robust causal inference from Mendelian randomization analyses with multiple genetic variants","volume":"28","author":"Burgess","year":"2017","journal-title":"Epidemiology"},{"key":"key\n\t\t\t\t2018112705033865600_key229-B15","first-page":"377","article-title":"Interpreting findings from Mendelian randomization using the MR-Egger method","volume":"32","author":"Burgess","year":"2017","journal-title":"Eur J Epidemiol"},{"key":"key\n\t\t\t\t2018112705033865600_key229-B16","first-page":"557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"key\n\t\t\t\t2018112705033865600_key229-B17","first-page":"e39321","article-title":"Serum uric acid and adiposity: deciphering causality using a bidirectional Mendelian randomization approach","volume":"7","author":"Lyngdoh","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2018112705033865600_key229-B18","first-page":"10495","article-title":"New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk","volume":"7","author":"Lu","year":"2016","journal-title":"Nat Commun"}],"container-title":["Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/rheumatology\/article-pdf\/57\/12\/2145\/26769424\/key229.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T05:04:05Z","timestamp":1543295045000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/rheumatology\/article\/57\/12\/2145\/5066615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,4]]},"references-count":18,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,8,4]]},"published-print":{"date-parts":[[2018,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/rheumatology\/key229","relation":{},"ISSN":["1462-0324","1462-0332"],"issn-type":[{"value":"1462-0324","type":"print"},{"value":"1462-0332","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,12]]},"published":{"date-parts":[[2018,8,4]]}}}