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Cardiovascular disease, infections, musculoskeletal conditions or malignancy are likely the most relevant comorbid conditions in pSS. Different infections (particularly oral candidal infections) and fibromyalgia are extremely frequent in the daily clinical practice. On the other hand, the incidence of cardiovascular events and cancer in pSS is low, so information about them comes from large epidemiological studies or meta-analysis. For this reason, preclinical vascular disease is investigated by different techniques, demonstrating the presence of early atherosclerosis in pSS patients. Coronary events could be slightly more frequent in pSS than in the general population. The overall risk of malignancy in pSS patients seems to be slightly increased, likely due to excess occurrence of lymphoma. An association between pSS and thyroid cancer might exist, although it should be confirmed by further investigations.<\/jats:p>","DOI":"10.1093\/rheumatology\/key329","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T19:15:18Z","timestamp":1539717318000},"page":"2075-2084","source":"Crossref","is-referenced-by-count":38,"title":["Comorbidities (excluding lymphoma) in Sj\u00f6gren\u2019s syndrome"],"prefix":"10.1093","volume":"60","author":[{"given":"Jos\u00e9 M.","family":"Pego-Reigosa","sequence":"first","affiliation":[{"name":"Rheumatology Department, University Hospital Complex of Vigo, Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Restrepo V\u00e9lez","sequence":"additional","affiliation":[{"name":"Rheumatology Department, University Hospital Complex of Vigo, Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Baldini","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00cd\u00f1igo","family":"R\u00faa-Figueroa Fern\u00e1ndez de Larrinoa","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Doctor Negr\u00edn University Hospital of Gran Canaria, Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,5,13]]},"reference":[{"key":"2021051418584154800_key329-B1","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1056\/NEJMcp1702514","article-title":"Primary Sj\u00f6gren\u2019s syndrome","volume":"378","author":"Mariette","year":"2018","journal-title":"N Engl J Med"},{"key":"2021051418584154800_key329-B2","article-title":"Association between primary Sj\u00f6gren\u2019s syndrome, cardiovascular 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