{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:23:43Z","timestamp":1788326623591,"version":"build-2803163510"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Division of Cancer Epidemiology and Genetics"},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["H18C2257"],"award-info":[{"award-number":["H18C2257"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The use of iodine-131\u00a0S values based on reference computational phantoms with fixed thyroid model may lead to significant dosimetric errors in patients who may have different thyroid location from the reference phantoms. In the present study, we investigated individual thyroid location variation by examining the computed tomography image sets of 40 adult male and female patients. Subsequently, the thyroid location of the adult male and female mesh-type reference phantoms of the International Commission on Radiological Protection (ICRP) was adjusted to match each the highest, mean and the lowest locations of the thyroid observed in this dataset. The thyroid-adjusted phantoms were implemented into the Geant4 Monte Carlo code to calculate thyroid location-dependent iodine-131\u00a0S values (rT\u00a0\u2190\u00a0thyroid) for a total of 30 target regions. The maximum variation among the observed thyroid locations was 39\u00a0mm and 36\u00a0mm for male and female patients, respectively. The mean thyroid locations of both male and female patients showed a good agreement with the ICRP reference phantoms. The thyroid location-dependent Iodine-131\u00a0S values were significantly different from the reference phantoms for most target regions by up to a factor of 3. The use of thyroid location-dependent S values in dose reconstructions should help quantify the dosimetric uncertainty in epidemiologic investigations of patients receiving iodine-131 therapy for hyperthyroidism and thyroid cancer.<\/jats:p>","DOI":"10.1093\/rpd\/ncaa027","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T20:10:51Z","timestamp":1581624651000},"page":"163-171","source":"Crossref","is-referenced-by-count":9,"title":["INVESTIGATION OF THE INFLUENCE OF THYROID LOCATION ON IODINE-131\u00a0S VALUES"],"prefix":"10.1093","volume":"189","author":[{"given":"Yeon Soo","family":"Yeom","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville MD 20850, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphn\u00e9e","family":"Villoing","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville MD 20850, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Greenstein","sequence":"first","affiliation":[{"name":"Bethesda-Chevy Chase High School, Bethesda, MD 20852, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cari M","family":"Kitahara","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville MD 20850, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Les R","family":"Folio","sequence":"first","affiliation":[{"name":"Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD 20852, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Hyeong","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Nuclear Engineering, Hanyang University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choonsik","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville MD 20850, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,4,14]]},"reference":[{"key":"2020071309123844500_ref1","first-page":"1287","article-title":"An analysis of \u201cablation of thyroid remnants\u201d with I-131 in 511 patients from 1947-1984: experience at University of Michigan","volume":"25","author":"Beierwaltes","year":"1984","journal-title":"J. Nucl. Med."},{"key":"2020071309123844500_ref2","first-page":"856","article-title":"Procedure guideline for therapy of thyroid disease with 131I odine","volume":"43","author":"Meier","year":"2002","journal-title":"J. Nucl. Med."},{"key":"2020071309123844500_ref3","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1001\/jama.280.4.347","article-title":"Cancer mortality following treatment for adult hyperthyroidism. Cooperative thyrotoxicosis therapy follow-up study group","volume":"280","author":"Ron","year":"1998","journal-title":"JAMA"},{"key":"2020071309123844500_ref4","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/oxfordjournals.rpd.a082685","article-title":"Radiation dosimetry in the treatment of thyroid carcinoma by 131I","volume":"5","author":"Smith","year":"1983","journal-title":"Radiat. Prot. Dosim."},{"key":"2020071309123844500_ref5","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/01.HP.0000206041.25242.c0","article-title":"Evaluation of the potential absorbed doses from patients based on whole-body 131I clearance in thyroid cancer therapy","volume":"91","author":"Willegaignon","year":"2006","journal-title":"Health Phys."},{"key":"2020071309123844500_ref6","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1667\/RR14160.1","article-title":"Organ dose estimates for hyperthyroid patients treated with 131I: an update of the thyrotoxicosis follow-up study","volume":"184","author":"Melo","year":"2015","journal-title":"Radiat. Res."},{"key":"2020071309123844500_ref7","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/rpd\/ncv016","article-title":"S values for 131I based on the ICRP adult voxel phantoms","volume":"168","author":"Lamart","year":"2016","journal-title":"Radiat. Prot. Dosim."},{"key":"2020071309123844500_ref8","doi-asserted-by":"crossref","first-page":"477","DOI":"10.2967\/jnumed.108.056036","article-title":"MIRD pamphlet no. 21: A generalized schema for radiopharmaceutical Dosimetry\u2014Standardization of nomenclature","volume":"50","author":"Bolch","year":"2009","journal-title":"J. Nucl. Med."},{"key":"2020071309123844500_ref9","first-page":"1","article-title":"Adult reference computational phantoms","volume":"39","author":"ICRP","year":"2009","journal-title":"Ann. ICRP"},{"key":"2020071309123844500_ref10","doi-asserted-by":"crossref","first-page":"7317","DOI":"10.1088\/0031-9155\/56\/22\/020","article-title":"Comparison of internal dosimetry factors for three classes of adult computational phantoms with emphasis on I-131 in the thyroid","volume":"56","author":"Lamart","year":"2011","journal-title":"Phys. Med. Biol."},{"key":"2020071309123844500_ref11","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1177\/0146645318756231","article-title":"New mesh-type phantoms and their dosimetric applications, including emergencies","volume":"47","author":"Kim","year":"2018","journal-title":"Ann. ICRP"},{"key":"2020071309123844500_ref12","doi-asserted-by":"crossref","first-page":"6985","DOI":"10.1088\/0031-9155\/58\/19\/6985","article-title":"Conversion of ICRP male reference phantom to polygon-surface phantom","volume":"58","author":"Yeom","year":"2013","journal-title":"Phys. Med. Biol."},{"key":"2020071309123844500_ref13","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.nima.2016.06.125","article-title":"Recent developments in Geant4","volume":"835","author":"Allison","year":"2016","journal-title":"Nucl. Instrum. Methods Phys. Res., Sect. A"},{"key":"2020071309123844500_ref14","doi-asserted-by":"crossref","first-page":"11:1","DOI":"10.1145\/2629697","article-title":"TetGen, a Delaunay-based quality tetrahedral mesh generator","volume":"41","author":"Si","year":"2015","journal-title":"ACM Trans. Math. Softw."},{"key":"2020071309123844500_ref15","first-page":"1","article-title":"The 2007 recommendations of the international commission on radiological protection","volume":"37","author":"ICRP","year":"2007","journal-title":"Ann. ICRP"},{"key":"2020071309123844500_ref16","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1088\/0031-9155\/59\/12\/3173","article-title":"Tetrahedral-mesh-based computational human phantom for fast Monte Carlo dose calculations","volume":"59","author":"Yeom","year":"2014","journal-title":"Phys. Med. Biol."},{"key":"2020071309123844500_ref17","article-title":"Nuclear decay data for Dosimetric calculations","volume":"38","author":"ICRP","year":"2008","journal-title":"Ann. ICRP"},{"key":"2020071309123844500_ref18","doi-asserted-by":"crossref","first-page":"7054","DOI":"10.1088\/0031-9155\/61\/19\/7054","article-title":"Development of skeletal system for mesh-type ICRP reference adult phantoms","volume":"61","author":"Yeom","year":"2016","journal-title":"Phys. Med. Biol."},{"key":"2020071309123844500_ref19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.icrp.2011.10.001","article-title":"Conversion coefficients for radiological protection quantities for external radiation exposures","volume":"40","author":"ICRP","year":"2010","journal-title":"Ann. ICRP"},{"key":"2020071309123844500_ref20","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1088\/0031-9155\/56\/8\/002","article-title":"Response functions for computing absorbed dose to skeletal tissues from photon irradiation\u2014An update","volume":"56","author":"Johnson","year":"2011","journal-title":"Phys. Med. Biol."},{"key":"2020071309123844500_ref21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0146-6453(03)00002-2","article-title":"Basic anatomical and physiological data for use in radiological protection: Reference values","volume":"32","author":"ICRP","year":"2002","journal-title":"Ann. ICRP"},{"key":"2020071309123844500_ref22","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1109\/JPROC.2009.2025399","article-title":"An algorithm for lymphatic node placement in hybrid computational phantoms: applications to radionuclide therapy dosimetry","volume":"97","author":"Lee","year":"2009","journal-title":"Proc. IEEE"},{"key":"2020071309123844500_ref23","first-page":"1","article-title":"Report on the task group on reference man","volume":"23","author":"ICRP","year":"1975","journal-title":"Ann. ICRP\/ICRP Publ."},{"key":"2020071309123844500_ref24","first-page":"1","article-title":"Human respiratory tract model for radiological protection: A report of a task Group of the International Commission on radiological protection","volume":"23","author":"ICRP","year":"1994","journal-title":"Ann. ICRP"}],"container-title":["Radiation Protection Dosimetry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/rpd\/article-pdf\/189\/2\/163\/33490322\/ncaa027.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/rpd\/article-pdf\/189\/2\/163\/33490322\/ncaa027.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T13:13:26Z","timestamp":1594646006000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/rpd\/article\/189\/2\/163\/5819661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":24,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,4,14]]},"published-print":{"date-parts":[[2020,7,13]]}},"URL":"https:\/\/doi.org\/10.1093\/rpd\/ncaa027","relation":{},"ISSN":["0144-8420","1742-3406"],"issn-type":[{"value":"0144-8420","type":"print"},{"value":"1742-3406","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,4]]},"published":{"date-parts":[[2020,4]]}}}