{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:40:48Z","timestamp":1765546848157,"version":"3.37.3"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"3-4","funder":[{"DOI":"10.13039\/100000015","name":"United States Department of Energy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Federal Medical Biological Agency"},{"name":"Joint Coordinating Committee for Radiation Effects Research","award":["AU0000902"],"award-info":[{"award-number":["AU0000902"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chelation therapy is sometimes used after potential exposures to plutonium to increase urinary excretion of the radionuclide to improve the accuracy of bioassay measurements. The purpose of this report is to describe the enhancement of urinary excretion of plutonium during and after the administration of the trisodium salt of calcium diethylenetriaminepentaacetate (Ca-DTPA) daily for 3\u00a0d to a group of male and female plutonium workers from the Mayak Production Association in Ozyorsk, Russia. One-hundred and two cases (18 females and 84 males) were selected where urinary contents of plutonium, prior to chelation, exceeded the detection threshold. Daily urine collections were obtained during the 3\u00a0d of Ca-DTPA treatments. In addition, 58 of these cases had urine bioassays at 1\u201345\u00a0d after chelation. The daily enhancement over baseline values excretion of plutonium was found to be 50.4\u00d7\/1.4 (geometric mean and geometric standard deviation); 58.9\u00d7\/1.2; 72.9\u00d7\/1.4 in the first, second and third days of Ca-DTPA administration. The mean enhancement for the 3-d period was 60.1\u00d7\/1.7. The rate of plutonium excretion from 1 to 45\u00a0d after chelation decreased with a half-period of 3.9\u00a0d and the chelation enhancement factor (\u041aenh-i) is described by the function \u041aenh-i\u00a0=\u00a0(0.79\u00a0\u00b1\u00a00.24)\u00a0+\u00a0(42.9\u00a0\u00b1\u00a01.2)\u00a0\u00d7\u00a0e\u2212(0.18\u00a0\u00b1\u00a00.01)\u00a0\u00d7\u00a0day.<\/jats:p>","DOI":"10.1093\/rpd\/ncab176","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T22:02:39Z","timestamp":1638309759000},"page":"154-162","source":"Crossref","is-referenced-by-count":2,"title":["URINARY EXCRETION OF PLUTONIUM IN MAYAK WORKERS DURING AND AFTER CA-DTPA ADMINISTRATION"],"prefix":"10.1093","volume":"197","author":[{"given":"Alexandra B","family":"Sokolova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klara G","family":"Suslova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2127-1243","authenticated-orcid":false,"given":"Scott C","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,12,26]]},"reference":[{"key":"2022020205052979700_ref1","first-page":"56","article-title":"Effectiveness of an urgent DTPA therapeutic treatment following penetration of 239Pu via skin","volume":"46","author":"Khokhryakov","year":"2001","journal-title":"Med. 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(Moscow: State Atomic Energy Corporation).","year":"2014","author":"ROSATOM","key":"2022020205052979700_ref11"},{"volume-title":"FDA Approved Drugs to Treat Internal Contamination from Radioactive Elements","year":"2004","author":"United States Food and Drug Administration (USFDA)","key":"2022020205052979700_ref12"},{"key":"2022020205052979700_ref13","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1667\/RR3371","article-title":"Mayak worker study: an improved biokinetic model for reconstructing doses from internally deposited plutonium","volume":"164","author":"Leggett","year":"2005","journal-title":"Radiat. 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Dosim."},{"key":"2022020205052979700_ref17","first-page":"123","article-title":"Effect of pentacyn and tetoxacyn on acceleration of plutonium elimination from human organism","volume":"3","author":"Plotnikova","year":"1962","journal-title":"Bull. Radiat. Risk"},{"key":"2022020205052979700_ref18","first-page":"23","article-title":"DTPA inhalation in diagnostic and treatment after Pu intake","volume":"2","author":"Plotnikova","year":"1980","journal-title":"Bull. Radiat. Med."},{"key":"2022020205052979700_ref19","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1093\/rpd\/ncx014","article-title":"The Mayak worker dosimetry system (MWDS-2013) for internally deposited plutonium: an overview","volume":"176","author":"Birchall","year":"2017","journal-title":"Radiat. Prot. 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Res."}],"container-title":["Radiation Protection Dosimetry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/rpd\/article-pdf\/197\/3-4\/154\/42356526\/ncab176.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/rpd\/article-pdf\/197\/3-4\/154\/42356526\/ncab176.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T05:12:50Z","timestamp":1643778770000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/rpd\/article\/197\/3-4\/154\/6483069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":42,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2021,12,26]]},"published-print":{"date-parts":[[2021,12,30]]}},"URL":"https:\/\/doi.org\/10.1093\/rpd\/ncab176","relation":{},"ISSN":["0144-8420","1742-3406"],"issn-type":[{"type":"print","value":"0144-8420"},{"type":"electronic","value":"1742-3406"}],"subject":[],"published-other":{"date-parts":[[2021,12]]},"published":{"date-parts":[[2021,12]]}}}