{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:17:31Z","timestamp":1791418651367,"version":"4.3.3"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"13-15","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The hematopoietic stem cells (HSCs) are sensitive to radiation. Chronic exposure to low dose rate (LDR) radiation at 20\u00a0mGy\/day results in a decrease in the number of HSCs and an increase of leukemia. In this study, the proliferative capacities of ex vivo HSCs, exposed to 20\u00a0mGy\/day of gamma-rays for 20\u00a0days, were compared with those of in vivo HSCs from similarly whole-body-irradiated mice. Radiation suppressed the growth of the ex vivo HSCs after Day 16 of irradiation and until Day 7 post-exposure. Almost all types of cells, particularly multipotent progenitors, common myeloid progenitors, granulocytes and macrophages, were significantly reduced in number at Day 20 of irradiation and Day 7 post-exposure in culture. HSCs and multipotent progenitors irradiated in vivo, however, decreased transiently and recovered by Day 7 post-exposure. These findings suggest that the microenvironment in vivo protects HSCs from the effects of LDR radiation.<\/jats:p>","DOI":"10.1093\/rpd\/ncac042","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T11:23:59Z","timestamp":1648553039000},"page":"1025-1029","source":"Crossref","is-referenced-by-count":2,"title":["COMPARISON OF THE PROLIFERATIVE RESPONSES OF HEMATOPOIETIC STEM CELLS EXPOSED TO LOW DOSE RATE RADIATION <i>IN VIVO<\/i> AND <i>EX VIVO<\/i>"],"prefix":"10.1093","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4000-8907","authenticated-orcid":false,"given":"Tokuhisa","family":"Hirouchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,9]]},"reference":[{"key":"2022090915091629800_ref1","doi-asserted-by":"crossref","first-page":"216","DOI":"10.2307\/3573095","article-title":"Leukemia in atomic bomb survivors, Hiroshima and Nagasaki, 1 October 1950\u2013 30 September 1966","volume":"45","author":"Ishimaru","year":"1971","journal-title":"Radiat. 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