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Tissue stem\/progenitor cells are a supposed origin of cancer and may contribute to the dose-rate effect on carcinogenesis. The authors have shown that female rats subjected to continuous whole body \u03b3 irradiation as juveniles or young adults have a notably reduced incidence of mammary cancer as compared with those irradiated acutely. Experiments using the mammosphere formation assay suggested the presence of radioresistant progenitor cells. Cell sorting indicated that basal progenitor cells in rat mammary gland were more resistant than luminal progenitors to killing by acute radiation, especially at high doses. Thus, the evidence indicates a cell-type-dependent inactivation of mammary cells that manifests only at high acute doses, implying a link to the observed dose-rate effect on carcinogenesis.<\/jats:p>","DOI":"10.1093\/rpd\/ncac050","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T11:18:34Z","timestamp":1648639114000},"page":"1036-1046","source":"Crossref","is-referenced-by-count":3,"title":["DOSE-RATE EFFECT OF RADIATION ON RAT MAMMARY CARCINOGENESIS AND AN EMERGING ROLE FOR STEM CELL BIOLOGY"],"prefix":"10.1093","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1507-585X","authenticated-orcid":false,"given":"Tatsuhiko","family":"Imaoka","sequence":"first","affiliation":[{"name":"National Institute of Radiological Sciences, National Institutes for Quantum Science and Technology Department of Radiation Effects Research, , Chiba 263-8555, 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