{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T06:02:01Z","timestamp":1768888921653,"version":"3.49.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"15-16","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Accidental inhalation intake of plutonium isotopes and 241Am occurred at a Pu research facility in Japan in 2017, and the five workers involved in this accident were treated by the administration of Ca\/Zn-diethylenetriaminepentaacetic acid (DTPA). For the worker who was most internally exposed, the therapy was continued over 1 y after the accident. Urinary samples collected before and after each administration were subject to bioassay to evaluate the efficacy of the dose reduction. This study performed numerical analyses using a biokinetic model dealing with 241Am-DTPA with reference to the European Coordinated Network on Radiation Dosimetry approach, which assumes that the complex of actinides and Ca\/Zn-DTPA is generated in the designated compartments in the biokinetic model. The results of the model prediction well captured the trend of the observed urinary excretion in the long-term bioassay and would be useful to evaluate the efficacy of the Ca\/Zn-DTPA administration for the worker involved in the accident.<\/jats:p>","DOI":"10.1093\/rpd\/ncac224","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T22:50:04Z","timestamp":1697064604000},"page":"2025-2029","source":"Crossref","is-referenced-by-count":1,"title":["Biokinetic model analysis with DTPA administration for a case of accidental inhalation of actinides in Japan"],"prefix":"10.1093","volume":"199","author":[{"given":"Kotaro","family":"Tani","sequence":"first","affiliation":[{"name":"National Institute of Radiological Sciences (NIRS), National Institutes for Quantum Science and Technology (QST) Department of Radiation Measurement and Dose Assessment, , 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhito","family":"Ishigure","sequence":"additional","affiliation":[{"name":"National Institute of Radiological Sciences (NIRS), National Institutes for Quantum Science and Technology (QST) Department of Radiation Measurement and Dose Assessment, , 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9339-8705","authenticated-orcid":false,"given":"Eunjoo","family":"Kim","sequence":"additional","affiliation":[{"name":"National Institute of Radiological Sciences (NIRS), National Institutes for Quantum Science and Technology (QST) Department of Radiation Measurement and Dose Assessment, , 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takako","family":"Tominaga","sequence":"additional","affiliation":[{"name":"National Institute of Radiological Sciences (NIRS), National Institutes for Quantum Science and Technology (QST) Department of Radiation Emergency Medicine, , 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Tatsuzaki","sequence":"additional","affiliation":[{"name":"National Institute of Radiological Sciences (NIRS), National Institutes for Quantum Science and Technology (QST) Department of Radiation Emergency Medicine, , 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Akashi","sequence":"additional","affiliation":[{"name":"National Institute of Radiological Sciences (NIRS), National Institutes for Quantum Science and Technology (QST) Department of Radiation Emergency Medicine, , 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Kurihara","sequence":"additional","affiliation":[{"name":"National Institute of Radiological Sciences (NIRS), National Institutes for Quantum Science and Technology (QST) Department of Radiation Measurement and Dose Assessment, , 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,10,11]]},"reference":[{"key":"2023101113581466600_ref1","article-title":"Contamination and exposure accidents of workers in \u201cFuel Research Facility\u201d at Oarai Research and Development Center","author":"Japan Atomic Energy Agency"},{"issue":"4","key":"2023101113581466600_ref2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.5453\/jhps.53.271","article-title":"Report of the JHPS working group for plutonium intake accident","volume":"53","author":"Iwai","year":"2018","journal-title":"Jpn. 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