{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:42:16Z","timestamp":1785796936156,"version":"3.56.0"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"14","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U19-AI067773"],"award-info":[{"award-number":["U19-AI067773"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["HHSN272201600040C"],"award-info":[{"award-number":["HHSN272201600040C"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Testing and validation of biodosimetry assays is routinely performed using conventional dose rate irradiation platforms, at a dose rate of approximately 1\u00a0Gy\/min. In contrast, the exposures from an improvised nuclear device will be delivered over a large range of dose rates with a prompt irradiation component, delivered in less than 1\u00a0\u03bcs, and a protracted component delivered over hours and days. We present preliminary data from a large demographic study we have undertaken for investigation of age, sex and dose rate effects on dicentric and micronucleus yields. Our data demonstrate reduced dicentric and micronucleus yields at very high dose rates. Additionally, we have seen small differences between males and females, with males having slightly fewer micronuclei and slightly more dicentrics than females, at high doses.<\/jats:p>","DOI":"10.1093\/rpd\/ncac286","type":"journal-article","created":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T07:46:53Z","timestamp":1695023213000},"page":"1495-1500","source":"Crossref","is-referenced-by-count":10,"title":["Sex and dose rate effects in automated cytogenetics"],"prefix":"10.1093","volume":"199","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5683-7318","authenticated-orcid":false,"given":"Guy","family":"Garty","sequence":"first","affiliation":[{"name":"Columbia University Radiological Research Accelerator Facility, , Irvington, NY 10027 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Royba","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center Center for Radiological Research, , New York, NY 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail","family":"Repin","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center Center for Radiological Research, , New York, NY 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9314-5708","authenticated-orcid":false,"given":"Igor","family":"Shuryak","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center Center for Radiological Research, , New York, NY 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naresh","family":"Deoli","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center Center for Radiological Research, , New York, NY 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razib","family":"Obaid","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center Center for Radiological Research, , New York, NY 10032 , USA"},{"name":"SLAC National Accelerator Laboratory , Menlo Park, CA 94025 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen C","family":"Turner","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center Center for Radiological Research, , New York, NY 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Brenner","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center Center for Radiological Research, , New York, NY 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,9,18]]},"reference":[{"key":"2023091807452985000_ref1","volume-title":"National Planning Scenarios (final version 21.3)","author":"Homeland Security Council","year":"2006"},{"issue":"2","key":"2023091807452985000_ref2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1097\/01.HP.0000348001.60905.c0","article-title":"Rapid radiation dose assessment for radiological public health emergencies: role of NIAID and BARDA","volume":"98","author":"Grace","year":"2010","journal-title":"Health Phys."},{"issue":"4","key":"2023091807452985000_ref3","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1667\/RR008CC.1","article-title":"Mice and the A-bomb: irradiation systems for realistic exposure scenarios","volume":"187","author":"Garty","year":"2017","journal-title":"Radiat. 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