{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:57:32Z","timestamp":1740139052276,"version":"3.37.3"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:00:00Z","timestamp":1678752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["NRF-2020M2C8A2069337","NRF-2020R1A2C1004272"],"award-info":[{"award-number":["NRF-2020M2C8A2069337","NRF-2020R1A2C1004272"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Inflammatory bowel diseases could be diagnosed in major measure by diagnostic imaging; however, radiation exposure in the intestine may also contribute to the progression of these pathologies. To better understand the impact of radiation in the presence of bowel disease, we administered dextran sodium sulfate (DSS) to C57BL\/6 mice to induce colitis and exposed to radiation at abdominal area. We observed that abdominal irradiation (13\u00a0Gy) aggravates the DSS-induced decrease in survival rate (0%), body weight (74.54\u00a0\u00b1\u00a03.59%) and colon length (4.98\u00a0\u00b1\u00a00.14\u00a0cm). Additionally, abdominal irradiation markedly increased in colonic inflammation levels (3.16\u00a0\u00b1\u00a00.16) compared with that of DSS-induced sham mice. Furthermore, abdominal irradiation also increased the mRNA expression levels of inflammatory genes, such as cyclooxygenase-2 (13.10 folds), interleukin-6 (48.83 folds) and tumor necrosis factor-alpha (42.97 folds). We conclude that abdominal irradiation aggravates the detrimental effects of DSS-induced colitis in mice, which might be a useful guideline for inflammatory bowel disease patients.<\/jats:p>","DOI":"10.1093\/rpd\/ncad051","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T21:26:17Z","timestamp":1678829177000},"page":"564-571","source":"Crossref","is-referenced-by-count":3,"title":["EFFECT OF ABDOMINAL IRRADIATION IN MICE MODEL OF INFLAMMATORY BOWEL DISEASE"],"prefix":"10.1093","volume":"199","author":[{"given":"Sohi","family":"Kang","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University , Gwangju 61186, The Republic o f Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeonghoon","family":"Son","sequence":"additional","affiliation":[{"name":"Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences , Seoul 01812, The Republic o f Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In-Sik","family":"Shin","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University , Gwangju 61186, The Republic o f Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changjong","family":"Moon","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University , Gwangju 61186, The Republic o f Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Y","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University , Daegu 41566, The Republic o f Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung S","family":"Lim","sequence":"additional","affiliation":[{"name":"Futuristic Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology , Ochang 28116, Chungbuk, The Republic o f Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Jin","family":"Park","sequence":"additional","affiliation":[{"name":"Futuristic Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology , Ochang 28116, Chungbuk, The Republic o f Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Geun","family":"Lee","sequence":"additional","affiliation":[{"name":"Research Center, Dongnam Institute of Radiological & Medical Sciences , Busan 46033, The Republic o f Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wol S","family":"Jo","sequence":"additional","affiliation":[{"name":"Research Center, Dongnam Institute of Radiological & Medical Sciences , Busan 46033, The Republic o f Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hae-June","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences , Seoul 01812, The Republic o f Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2180-4860","authenticated-orcid":false,"given":"Joong S","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University , Gwangju 61186, The Republic o f Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,3,14]]},"reference":[{"issue":"2","key":"2023041910490116200_ref1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.25122\/jml-2018-0075","article-title":"A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease","volume":"12","author":"Seyedian","year":"2019","journal-title":"J. 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Pharmacol."},{"issue":"2","key":"2023041910490116200_ref31","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1572-0241.2006.00384.x","article-title":"The gastrointestinal safety and effect on disease activity of etoricoxib, a selective cox-2 inhibitor in inflammatory bowel diseases","volume":"101","author":"El Miedany","year":"2006","journal-title":"Off. J. Am. Coll. Gastroenterol."},{"issue":"3","key":"2023041910490116200_ref32","doi-asserted-by":"crossref","first-page":"e00213","DOI":"10.1128\/mSystems.00213-17","article-title":"Interleukin 1\u03b1-deficient mice have an altered gut microbiota leading to protection from dextran sodium sulfate-induced colitis","volume":"3","author":"Nunberg","year":"2018","journal-title":"MSystems"},{"issue":"52","key":"2023041910490116200_ref33","doi-asserted-by":"crossref","first-page":"26717","DOI":"10.1073\/pnas.1915043116","article-title":"Neutralization of IL-1\u03b1 ameliorates Crohn\u2019s disease-like ileitis by functional alterations of the gut microbiome","volume":"116","author":"Menghini","year":"2019","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"5","key":"2023041910490116200_ref34","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1172\/JCI21404","article-title":"IL-23 is essential for T cell\u2013mediated colitis and promotes inflammation via IL-17 and IL-6","volume":"116","author":"Yen","year":"2006","journal-title":"J. Clin. Invest."},{"issue":"8","key":"2023041910490116200_ref35","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.3390\/ijms19082244","article-title":"Anti-TNF therapy in Crohn\u2019s disease","volume":"19","author":"Adegbola","year":"2018","journal-title":"Int. J. Mol. 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Pharmacol."},{"issue":"1","key":"2023041910490116200_ref39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-017-0763-3","article-title":"BCN057 induces intestinal stem cell repair and mitigates radiation-induced intestinal injury","volume":"9","author":"Bhanja","year":"2018","journal-title":"Stem Cell Res. Ther."},{"issue":"2","key":"2023041910490116200_ref40","first-page":"89","article-title":"Dose-response curves of mouse Jejunal crypt cells by Multifrationated Irrdiation","volume":"4","author":"Hong","year":"1986","journal-title":"J. Korean Soc. Ther. Radiol."},{"issue":"3","key":"2023041910490116200_ref41","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2307\/3573432","article-title":"Intestinal crypt survival and total and per crypt levels of proliferative cellularity following irradiation: single x-ray exposures","volume":"46","author":"Hagemann","year":"1971","journal-title":"Radiat. 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