{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:04:39Z","timestamp":1767906279458,"version":"3.49.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"14","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Scientific Research Projects Coordination Unit","award":["18401142"],"award-info":[{"award-number":["18401142"]}]},{"name":"Sel\u00e7uk University in T\u00fcrkiye"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Among many sterilization methods, radiosterilization is a preferred method in the pharmaceutical industry because of its advantages. However, the detection of radiosterilization of drugs is a growing concern for many government regulatory agencies around the world because of changes in the drug\u2019s structure because of exposure to radiation. Electron Paramagnetic Resonance (EPR) proved to be a very sensitive technique to discriminate between irradiated and nonirradiated drugs and detect radicals for days even to years. In this study, the focus is on the detection of radiosterilization of irradiated three asthma drugs (Airfix, Ventolin and Prednol) by using EPR spectroscopy. Regarding the commercial aspects of drugs, it was found that radicals can be detected at least 2\u00a0y after irradiation. Therefore, paramagnetic centers formed by the effect of radiation in the samples were determined and the stability of these centers was examined for 2\u00a0y by performing the fading study.<\/jats:p>","DOI":"10.1093\/rpd\/ncad165","type":"journal-article","created":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T07:49:16Z","timestamp":1695023356000},"page":"1600-1604","source":"Crossref","is-referenced-by-count":6,"title":["Gamma irradiation effect on some asthma drugs: EPR detection of radiosterilization"],"prefix":"10.1093","volume":"199","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5954-3689","authenticated-orcid":false,"given":"Ece","family":"Emel","sequence":"first","affiliation":[{"name":"Karamano\u011flu Mehmetbey University Kamil \u00d6zda\u011f Faculty of Science, Department of Physics, , Karaman 70100 , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozmen","family":"Ayhan","sequence":"additional","affiliation":[{"name":"Sel\u00e7uk University Faculty of Science, Department of Physics, , Konya 42200 , T\u00fcrkiye"},{"name":"Sel\u00e7uk University Advanced Technology Research and Application Center, , Konya 42200 , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biyik","family":"Recep","sequence":"additional","affiliation":[{"name":"Turkish Energy, Nuclear and Mineral Research Agency , \u0130stanbul 34303 , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayin","family":"Ulku","sequence":"additional","affiliation":[{"name":"Sel\u00e7uk University Faculty of Science, Department of Physics, , Konya 42200 , T\u00fcrkiye"},{"name":"Sel\u00e7uk University Advanced Technology Research and Application Center, , Konya 42200 , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,9,18]]},"reference":[{"issue":"2","key":"2023091807463425000_ref1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0378-5173(96)04661-3","article-title":"Radiosterilization dosimetry by ESR spectroscopy: application to terbutaline","volume":"142","author":"Basly","year":"1996","journal-title":"Int. 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