{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:19:14Z","timestamp":1791901154192,"version":"4.3.4"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"16-18","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"JSPS KAKENHI","award":["JP20K12192"],"award-info":[{"award-number":["JP20K12192"]}]},{"name":"Environmental Radioactivity Research Network Center","award":["Y-22-28"],"award-info":[{"award-number":["Y-22-28"]}]},{"name":"Environmental Radioactivity Research Network Center","award":["Y-23-28"],"award-info":[{"award-number":["Y-23-28"]}]},{"name":"Environmental Radioactivity Research Network Center","award":["P-23-32"],"award-info":[{"award-number":["P-23-32"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study investigated the effects of chronic low-dose-rate radiation exposure on gene expression related to immunological defense mechanisms and epigenetic regulation in the testis of male mice. The study found that radiation exposure (4.5 mGy\/hr until 4000 mGy) led to a significant decrease in the expression of genes involved in epigenetic regulation and a significant increase in the expression of several genes linked to innate and acquired immunity, suggesting a noticeable effect on the immune response. In addition, there was a significant increase in the expression of SRY-box transcription factor 9, which plays a crucial role in testicular development, indicating a response to irradiation. These findings provide insights into the biological effects of chronic low-dose-rate radiation exposure on innate immunity and epigenetic regulation in the testis.<\/jats:p>","DOI":"10.1093\/rpd\/ncae063","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T09:42:49Z","timestamp":1709631769000},"page":"1620-1624","source":"Crossref","is-referenced-by-count":10,"title":["Effects of low-dose rate radiation on immune and epigenetic regulation of the mouse testes"],"prefix":"10.1093","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9457-3127","authenticated-orcid":false,"given":"Ippei","family":"Uemura","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Hokkaido University of Science , 7-Jo 15-4-1 Maeda, Teine-ku, Sapporo, Hokkaido 006-8585,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsuko","family":"Takahashi-Suzuki","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Hokkaido University of Science , 7-Jo 15-4-1 Maeda, Teine-ku, Sapporo, Hokkaido 006-8585,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saki","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Hokkaido University of Science , 7-Jo 15-4-1 Maeda, Teine-ku, Sapporo, Hokkaido 006-8585,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaede","family":"Kumagai","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Hokkaido University of Science , 7-Jo 15-4-1 Maeda, Teine-ku, Sapporo, Hokkaido 006-8585,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Tsutsumi","sequence":"additional","affiliation":[{"name":"Department of Radiobiology, Institute for Environmental Science , 2-121 Hachazawa, Takahoko, Rokkasho, Kamikita, Aomori 039-3212,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6716-4059","authenticated-orcid":false,"given":"Donovan","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Risk Analysis and Biodosimetry, Institute of Radiation Emergency Medicine, Hirosaki University , 66-1 Hon-cho, Hirosaki, Aomori 036-8564,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Satoh","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Hokkaido University of Science , 7-Jo 15-4-1 Maeda, Teine-ku, Sapporo, Hokkaido 006-8585,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Yamashiro","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, Niigata University , 8050 Ikarashi Ninocho Nishiku Niigata, Niigata 959-2181,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3104-2134","authenticated-orcid":false,"given":"Tomisato","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Risk Analysis and Biodosimetry, Institute of Radiation Emergency Medicine, Hirosaki University , 66-1 Hon-cho, Hirosaki, Aomori 036-8564,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8813-9802","authenticated-orcid":false,"given":"Kazumi","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Department of Radiobiology, Institute for Environmental Science , 2-121 Hachazawa, Takahoko, Rokkasho, Kamikita, Aomori 039-3212,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8728-1655","authenticated-orcid":false,"given":"Akifumi","family":"Nakata","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Hokkaido University of Science , 7-Jo 15-4-1 Maeda, Teine-ku, Sapporo, Hokkaido 006-8585,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"key":"2024111411305928200_ref1","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1038\/srep02850","article-title":"Effects of radioactive caesium on bull testes after the Fukushima nuclear plant accident","volume":"3","author":"Yamashiro","year":"2013","journal-title":"Sci. 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