{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T10:41:14Z","timestamp":1756464074666,"version":"3.44.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"13-14","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Swedish government and the county councils\u2014the ALF-agreement","award":["ALFGBG-966074"],"award-info":[{"award-number":["ALFGBG-966074"]}]},{"DOI":"10.13039\/501100002794","name":"Swedish Cancer Society","doi-asserted-by":"publisher","award":["20 1293"],"award-info":[{"award-number":["20 1293"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2021-02636"],"award-info":[{"award-number":["2021-02636"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>131I (iodide) accumulates in the thyroid and may affect thyroid tissue. Mechanisms behind such effects are not known. The aim was to investigate early changes in protein expression in thyroid and plasma from mice injected with 131I as iodide. Female Balb\/c nude mice were i.v. injected with 0 or 490\u00a0kBq 131I and killed after 24\u00a0h. Thyroid and blood samples were collected from each animal. Protein levels were determined by mass spectrometry. Data are available via ProteomeXchange with identifier PXD062861. Altogether, 17 and 20 proteins showed statistically significant altered levels in thyroid gland and plasma, respectively, after 131I exposure. Most of these proteins had decreased and increased levels in thyroid and plasma, respectively. Few of them were previously proposed radiation responsive proteins. Functional annotation suggests impact on haematopoiesis, reduced oxygen levels, and hypothyroidism. The role of CHIA and PGAM2 in radiation-induced response should be further examined, together with identification and validation of biomarkers of 131I exposure.<\/jats:p>","DOI":"10.1093\/rpd\/ncaf057","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T09:36:42Z","timestamp":1747993002000},"page":"887-898","source":"Crossref","is-referenced-by-count":1,"title":["Early proteomic response in thyroid gland after 131I administration in female Balb\/c mice"],"prefix":"10.1093","volume":"201","author":[{"given":"Nils","family":"Rudqvist","sequence":"first","affiliation":[{"name":"Department of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy, University of Gothenburg , Sahlgrenska University Hospital, SE-413 45 Gothenburg,","place":["Sweden"]},{"name":"Sahlgrenska Cancer Center, Sahlgrenska Academy, University of Gothenburg , Box 425, SE-405 30 Gothenburg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Spetz","sequence":"additional","affiliation":[{"name":"Department of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy, University of Gothenburg , Sahlgrenska University Hospital, SE-413 45 Gothenburg,","place":["Sweden"]},{"name":"Sahlgrenska Cancer Center, Sahlgrenska Academy, University of Gothenburg , Box 425, SE-405 30 Gothenburg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emil","family":"Sch\u00fcler","sequence":"additional","affiliation":[{"name":"Department of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy, University of Gothenburg , Sahlgrenska University Hospital, SE-413 45 Gothenburg,","place":["Sweden"]},{"name":"Sahlgrenska Cancer Center, Sahlgrenska Academy, University of Gothenburg , Box 425, SE-405 30 Gothenburg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshima Z","family":"Parris","sequence":"additional","affiliation":[{"name":"Sahlgrenska Cancer Center, Sahlgrenska Academy, University of Gothenburg , Box 425, SE-405 30 Gothenburg,","place":["Sweden"]},{"name":"Department of Oncology, Institute of Clinical Sciences, University of Gothenburg , Sahlgrenska University Hospital, SE-413 45 Gothenburg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britta","family":"Langen","sequence":"additional","affiliation":[{"name":"Department of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy, University of Gothenburg , Sahlgrenska University Hospital, SE-413 45 Gothenburg,","place":["Sweden"]},{"name":"Sahlgrenska Cancer Center, Sahlgrenska Academy, University of Gothenburg , Box 425, SE-405 30 Gothenburg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carina Sihlbom","family":"Wallem","sequence":"additional","affiliation":[{"name":"Sambio Core Facilities, Sahlgrenska Academy, University of Gothenburg , Box 413, SE-405 30 Gothenburg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalil","family":"Helou","sequence":"additional","affiliation":[{"name":"Sahlgrenska Cancer Center, Sahlgrenska Academy, University of Gothenburg , Box 425, SE-405 30 Gothenburg,","place":["Sweden"]},{"name":"Department of Oncology, Institute of Clinical Sciences, University of Gothenburg , Sahlgrenska University Hospital, SE-413 45 Gothenburg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7558-4368","authenticated-orcid":false,"given":"Eva","family":"Forssell-Aronsson","sequence":"additional","affiliation":[{"name":"Department of Medical Radiation Sciences, 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