{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:15:43Z","timestamp":1761092143726,"version":"build-2065373602"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"17","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100013318","name":"Shanxi Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["202303021222406"],"award-info":[{"award-number":["202303021222406"]}],"id":[{"id":"10.13039\/501100013318","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The dicentric chromosome assay serves as the \u201cgold standard\u201d for biodosimetry, playing a crucial role in rapid clinical decision-making during extensive nuclear radiation incidents. This study aimed to develop a semi-automated dose\u2013response curve for the analysis of dicentric chromosomes induced by irradiation of human peripheral blood lymphocytes with 60Co gamma rays. Blood samples were collected from three healthy donors and subjected to irradiation, culture, and harvesting, following International Atomic Energy Agency standard protocols. The Metafer4 system, an automatic scoring system, was utilized to acquire images of the metaphase chromosome segregation phase, and the dose\u2013response curve was constructed through automatic analysis of dicentric chromosomes supplemented by manual verification. The curve was subsequently validated through blind scoring. The results demonstrated that the semi-automated scoring method provides quick and precise dose estimations and offers a viable alternative to manual dicentric chromosome assay. This approach holds significant potential for application in the nuclear emergency management of large-scale radiological events.<\/jats:p>","DOI":"10.1093\/rpd\/ncaf101","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T19:49:21Z","timestamp":1758224961000},"page":"1152-1158","source":"Crossref","is-referenced-by-count":0,"title":["Establishment and validation of a dose\u2013response curve for semi-automated analysis of dicentric chromosomes induced by 60Co \u03b3-rays"],"prefix":"10.1093","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5723-4356","authenticated-orcid":false,"given":"Qian-Qian","family":"Meng","sequence":"first","affiliation":[{"name":"China Institute for Radiation Protection (CIRP) , 102 Xuefu Street, Taiyuan City, Shanxi Province, 030006 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Ren","sequence":"additional","affiliation":[{"name":"China Institute for 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