{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T10:19:25Z","timestamp":1783333165906,"version":"3.54.6"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"JSPS KAKENHI","award":["22K07751"],"award-info":[{"award-number":["22K07751"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Recent Boron neutron capture therapy (BNCT) has shifted to accelerator-based systems. One of them is a compact neutron generator developed using silicon carbide (SiC) semiconductors by Fukushima SiC Applied Technology Co. However, neutron penetration remains a critical challenge for treating deep-seated tumors. This study investigated the potential of neutron sieve therapy, originally developed to enhance the depth dose distribution in X-ray therapy, to improve BNCT dose distribution via Monte Carlo simulations based on the Fukushima SiC BNCT system. Dose distribution changes were investigated using polyethylene and 6LiF-plastic in block and sieve shapes. The results show that the maximum thermal neutron fluence depth was shallower (deeper) with polyethylene (6LiF-plastic) filters. The sieve filter moderately altered the dose distribution compared to the block filter due to density differences. The maximum dose point shifted 8\u00a0mm deeper using a sieve filter composed of 6LiF-plastic and polyethylene, with a 5.5% increase at 20\u00a0mm depth in neutron fluence at the same skin dose.<\/jats:p>","DOI":"10.1093\/rpd\/ncag018","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T12:50:14Z","timestamp":1770900614000},"page":"845-849","source":"Crossref","is-referenced-by-count":0,"title":["Impact of neutron sieve therapy for deep site in boron neutron capture therapy using Monte Carlo calculation"],"prefix":"10.1093","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8155-5758","authenticated-orcid":false,"given":"Keiichiro","family":"Matsushita","sequence":"first","affiliation":[{"name":"Fukui Prefectural Hospital , 2-8-1 Yotsui, Fukui City, Fukui 910-8526 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7508-7217","authenticated-orcid":false,"given":"Hideya","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , 465 Kajiicho Kawaramachi Hirokoji, Kamigyo-ku, Kyoto 602-8566 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Matsubara","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Fujita Health University , 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"2026070606011010000_ref1","author":"Fukushima SiC Applied Engineering Inc","year":"2019"},{"key":"2026070606011010000_ref2"},{"key":"2026070606011010000_ref3","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1038\/bjc.1961.55","article-title":"X-ray sieve therapy of bronchial carcinoma","volume":"15","author":"Jolles","year":"1961","journal-title":"Br J Cancer"},{"key":"2026070606011010000_ref4","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.ijrobp.2019.01.073","article-title":"A current review of spatial fractionation: back to the future?","volume":"104","author":"Billena","year":"2019","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2026070606011010000_ref5","doi-asserted-by":"publisher","first-page":"7409","DOI":"10.1088\/0031-9155\/52\/24\/014","article-title":"Improvement of dose distribution by central beam shielding in boron neutron capture therapy","volume":"52","author":"Sakurai","year":"2007","journal-title":"Phys Med Biol"},{"key":"2026070606011010000_ref6","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1016\/j.ijrobp.2006.11.022","article-title":"Improved dose targeting for a clinical epithermal neutron capture beam using optional (6) Li filtration","volume":"67","author":"Binns","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2026070606011010000_ref7","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/S0168-9002(03)01368-8","article-title":"Geant 4\u2014a simulation toolkit","volume":"506","author":"Agostinelli","year":"2003","journal-title":"Nucl Instrum Methods Phys Res Sect A"}],"container-title":["Radiation Protection Dosimetry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/rpd\/article-pdf\/202\/11\/845\/67201368\/ncag018.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/rpd\/article-pdf\/202\/11\/845\/67201368\/ncag018.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T10:01:17Z","timestamp":1783332077000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/rpd\/article\/202\/11\/845\/8503612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,2]]},"references-count":7,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,3,2]]},"published-print":{"date-parts":[[2026,7,6]]}},"URL":"https:\/\/doi.org\/10.1093\/rpd\/ncag018","relation":{},"ISSN":["0144-8420","1742-3406"],"issn-type":[{"value":"0144-8420","type":"print"},{"value":"1742-3406","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7]]},"published":{"date-parts":[[2026,3,2]]}}}