{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:39:49Z","timestamp":1792600789216,"version":"4.5.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sentinel lymph node biopsy is critical for breast cancer staging and management. While 99mTc-Phytate is the established standard radiotracer, 99mTc-Antimony Trisulfide has limited clinical application due to radiopharmaceutical supply constraints. This proof-of-concept study evaluates both radiotracers\u2019 diagnostic effectiveness and validates 99mTc-Antimony Trisulfide as a viable alternative. This institutional study included 39 breast cancer patients undergoing sentinel lymph node biopsy. Patients received either 99mTc-Phytate (n\u00a0=\u00a028; 71.8%) or 99mTc-Antimony Trisulfide (n\u00a0=\u00a010; 25.6%) via periareolar (n\u00a0=\u00a024) or peritumoral (n\u00a0=\u00a015) injection. Sentinel lymph node identification and gamma probe concordance were analyzed. Mean patient age was 53.5\u00a0\u00b1\u00a09.5\u00a0years. Invasive ductal carcinoma predominated (87%). 99mTc-Phytate achieved 100% detection (28 of 28 patients), while 99mTc-Antimony Trisulfide achieved 90.9% (10 of 11 patients). Intraoperative gamma probe concordance was 100% in all successfully visualized cases (38 of 38). Both radiotracers effectively identify sentinel lymph nodes with high diagnostic accuracy. While 99mTc-Phytate remains the preferred first-line agent, 99mTc-Antimony Trisulfide represents a validated alternative, particularly valuable in resource-limited settings or during radiopharmaceutical supply disruptions.<\/jats:p>","DOI":"10.1093\/rpd\/ncag058","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:46:09Z","timestamp":1792583169000},"source":"Crossref","is-referenced-by-count":0,"title":["Comparison of 99mTc-Phytate and 99mTc-Antimony Trisulfide in sentinel lymph node detection: a lymphoscintigraphy study in breast cancer patients"],"prefix":"10.1093","author":[{"given":"Saba","family":"Madani","sequence":"first","affiliation":[{"name":"Department of Medical Radiation Engineering, CT.C., Islamic Azad University , Tehran ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esmaeil","family":"Gharepapagh","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Medical School, Tabriz University of Medical Sciences , Tabriz ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5680-0002","authenticated-orcid":false,"given":"Mehdi Salehi","family":"Barough","sequence":"additional","affiliation":[{"name":"Department of Medical Radiation Engineering, CT.C., Islamic Azad University , Tehran ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noushin Benai","family":"Rezaieh","sequence":"additional","affiliation":[{"name":"Department of Medical Radiation Engineering, CT.C., Islamic Azad University , Tehran ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Montazer","sequence":"additional","affiliation":[{"name":"Department of Medical Radiation Engineering, CT.C., Islamic Azad University , Tehran ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morteza","family":"Azizi","sequence":"additional","affiliation":[{"name":"Department of Medical Radiation Engineering, CT.C., Islamic Azad University , Tehran ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Rezaei","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Medical School, Tabriz University of Medical Sciences , Tabriz ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"2026102111502274400_ref1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0169-409X(01)00150-8","article-title":"The physiology of the lymphatic system","volume":"50","author":"Swartz","year":"2001","journal-title":"Adv Drug Deliv 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