{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:40:11Z","timestamp":1792496411483,"version":"4.5.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"17","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Accurate calibration of biological dosimetry methods is crucial for reliable radiation dose assessment in both medical and research contexts. However, discrepancies in calibration coefficients (\u03b1, \u03b2, c) across various studies impede standardization and the comparability of dose\u2013response curves. This study conducted a systematic analysis of calibration data from 62 studies covering different radiation types (60Co gamma rays, 137Cs gamma rays, and X-rays) with varying energies and dose rates (0.00196\u201323.85\u00a0Gy\/min), to explore the sources of variability and their effects on dicentric chromosome yields. Using descriptive statistics, analysis of variance, Kruskal\u2013Wallis tests, and correlation analyses, we found significant differences in \u03b1 and \u03b2 coefficients across different dose rate categories for 60Co gamma rays (P\u00a0&amp;lt;\u00a0.05). Specifically, the \u03b1 coefficient increased from 0.022\u00a0\u00b1\u00a00.015 at low dose rates (0\u20130.5\u00a0Gy\/min) to 0.049\u00a0\u00b1\u00a00.021 at higher dose rates (&amp;gt;1\u00a0Gy\/min). Moreover, no significant differences were detected between the Computer-Assisted Brain Analysis System (CABAS) and Dose Estimate software for estimating coefficients (P\u00a0&amp;gt;\u00a0.05 for \u03b1, \u03b2, c), indicating consistency in the methodological outputs of these software tools. The observed variability was attributed to factors such as radiation quality, experimental protocols, and inter-laboratory differences. These findings highlight the necessity for standardized calibration protocols that take radiation parameters into account. We propose the development of harmonized experimental setups and reference curves to improve comparability across studies, ultimately enhancing the accuracy of biological dosimetry for radiation protection and epidemiological research. In alignment with existing International Atomic Energy Agency and International Organization for Standardization (ISO) guidelines and acknowledging that international ring-trial intercomparisons remain essential for ensuring comparability across laboratories.<\/jats:p>","DOI":"10.1093\/rpd\/ncag065","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T11:41:54Z","timestamp":1780746114000},"page":"1401-1413","source":"Crossref","is-referenced-by-count":0,"title":["A multi-study analysis of variability in calibration coefficients for radiation dose estimation via the dicentric chromosome assay"],"prefix":"10.1093","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3352-863X","authenticated-orcid":false,"given":"Morteza","family":"Kosarnia","sequence":"first","affiliation":[{"name":"Department of Medical Physics, Faculty of Medicine, Mashhad University of Medical Sciences, Razavi Khorasan Province, Pardis Daneshgah , Vakilabad Blvd., Mashhad 9177948564 ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Khakshor","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, Faculty of Medicine, Mashhad University of Medical Sciences, Razavi Khorasan Province, Pardis Daneshgah , Vakilabad Blvd., Mashhad 9177948564 ,","place":["Iran"]},{"name":"Cellular and Molecular Research Center, Sabzevar University of Medical Sciences , Razavi Khorasan Province, Shohadaye Hasteiee Blvd., Sabzevar 9617913112 ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Najafian","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, Faculty of Medicine, Mashhad University of Medical Sciences, Razavi Khorasan Province, Pardis Daneshgah , Vakilabad Blvd., Mashhad 9177948564 ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2951-8228","authenticated-orcid":false,"given":"Hosein","family":"Azimian","sequence":"additional","affiliation":[{"name":"Medical Physics Research Center, Basic Sciences Research Institute, Mashhad University of Medical Sciences , Razavi Khorasan Province, Pardis Daneshgah, Vakilabad Blvd., Mashhad 9177948564 ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"2026102006465489500_ref1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00411-014-0519-8","article-title":"Web-based scoring of the dicentric assay, a collaborative biodosimetric scoring strategy for population triage in large scale radiation accidents","volume":"53","author":"Romm","year":"2014","journal-title":"Radiat Environ 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