{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:35:40Z","timestamp":1791909340288,"version":"4.3.4"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T00:00:00Z","timestamp":1644796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172530"],"award-info":[{"award-number":["82172530"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Program of Guangdong","doi-asserted-by":"publisher","award":["2018B030334001"],"award-info":[{"award-number":["2018B030334001"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangzhou Science and Technology project","award":["202007030012"],"award-info":[{"award-number":["202007030012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Subthreshold depression (SD) is regarded as a major risk factor for major depression. However, little is known about the neural mechanism of negative emotion processing in SD. The study aimed to examine the different neural correlates for negative emotion processing in SD and health controls (HCs) and to investigate changes in functional connectivity in SD compared with HC. Blood oxygenation level-dependent (BOLD) responses of SD and HC were captured while performing a passive viewing task, which comprised a negative condition and a masked condition. A total of 42 SD and 32 HC adolescents participated in the study. Between-group comparisons revealed significant reduced activations in the superior frontal gyrus (SFG), middle frontal gyrus and middle cingulate gyrus. Region of interest (ROI) analyses did not find correlations between contrast values of the ROIs and depressive symptoms. In addition, we found a significant increased functional connectivity between the SFG and caudate, pallidum and insula, which was significantly correlated with depressive symptoms in the SD group (P\u2009&amp;lt;\u20090.05). Altered functional connectivity between the SFG and caudate, pallidum and insula may underlie the pathology of SD. This is the first study to investigate neural mechanisms of negative emotion processing in SD using task-based functional magnetic resonance imaging.<\/jats:p>","DOI":"10.1093\/scan\/nsac003","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T12:11:57Z","timestamp":1644581517000},"page":"655-661","source":"Crossref","is-referenced-by-count":37,"title":["Neural correlates of negative emotion processing in subthreshold depression"],"prefix":"10.1093","volume":"17","author":[{"given":"Shu","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Public Health and Preventive Medicine, School of Basic Medicine and Public Health, Jinan University , Guangzhou 510632, China"},{"name":"Division of Medical Psychology and Behavior Science, School of Basic Medicine and Public Health, Jinan University , Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Public Health and Preventive Medicine, School of Basic Medicine and Public Health, Jinan University , Guangzhou 510632, China"},{"name":"Division of Medical Psychology and Behavior Science, School of Basic Medicine and Public Health, Jinan University , Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Public Health and Preventive Medicine, School of Basic Medicine and Public Health, Jinan University , Guangzhou 510632, China"},{"name":"Division of Medical Psychology and Behavior Science, School of Basic Medicine and Public Health, Jinan University , Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangzhang","family":"Qi","sequence":"additional","affiliation":[{"name":"Medical Imaging Center, First Affiliated Hospital of Jinan University , Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0388-4177","authenticated-orcid":false,"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical Imaging Center, First Affiliated Hospital of Jinan University , Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9725-1871","authenticated-orcid":false,"given":"Qian","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Public Health and Preventive Medicine, School of Basic Medicine and Public Health, Jinan University , Guangzhou 510632, China"},{"name":"Division of Medical Psychology and Behavior Science, School of Basic Medicine and Public Health, Jinan University , Guangzhou 510632, China"},{"name":"Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong-Macao Greater Bay Area , Guangzhou 510515, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,2,14]]},"reference":[{"issue":"2","key":"2022070213564064600_R1","first-page":"187","article-title":"A controlled study of repetitive transcranial magnetic stimulation in medication-resistant major depression","volume":"59","author":"Avery","year":"2006","journal-title":"BiologicalPsychiatry"},{"issue":"5","key":"2022070213564064600_R2","first-page":"919","article-title":"Functional connectivity of the left DLPFC to striatum predicts treatment response of depression to TMS","volume":"10","author":"Avissar","year":"2017","journal-title":"BrainStimulation"},{"key":"2022070213564064600_R3","volume-title":"Beck Depression Inventory (BDI-II)","author":"Beck","year":"1996"},{"key":"2022070213564064600_R4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.neuropsychologia.2014.08.013","article-title":"The amygdala as a hub in brain networks that support social life","volume":"63","author":"Bickart","year":"2014","journal-title":"Neuropsychologia"},{"issue":"1","key":"2022070213564064600_R5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0005-7916(94)90063-9","article-title":"Measuring emotion: the self-assessment manikin and the semantic differential","volume":"25","author":"Bradley","year":"1994","journal-title":"Journal of Behavior Therapy and Experimental Psychiatry"},{"issue":"5","key":"2022070213564064600_R6","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1600-0447.2004.00301.x","article-title":"Subthreshold depression as a risk indicator for major depressive disorder: a systematic review of prospective studies","volume":"109","author":"Cuijpers","year":"2004","journal-title":"ActaPsychiatrica Scandinavica"},{"issue":"1\u20133","key":"2022070213564064600_R7","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jad.2006.10.010","article-title":"Subsyndromal depression: an impact on quality of life?","volume":"100","author":"da Silva Lima","year":"2007","journal-title":"Journal of Affective Disorders"},{"issue":"8","key":"2022070213564064600_R8","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nrn3027","article-title":"Neural mechanisms of the cognitive model of depression","volume":"12","author":"Disner","year":"2011","journal-title":"Nature Reviews Neuroscience"},{"key":"2022070213564064600_R9","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.neuroscience.2012.10.048","article-title":"Stress and the developing adolescent brain","volume":"249","author":"Eiland","year":"2013","journal-title":"Neuroscience"},{"issue":"7","key":"2022070213564064600_R10","first-page":"2369","article-title":"Resting-state functional connectivity of the human habenula in healthy individuals: associations with subclinical depression","volume":"37","author":"Ely","year":"2016","journal-title":"HumanBrainMapping"},{"issue":"4","key":"2022070213564064600_R11","first-page":"377","article-title":"Altered emotional interference processing in affective and cognitive-control brain circuitry in major depression","volume":"63","author":"Fales","year":"2008","journal-title":"BiologicalPsychiatry"},{"issue":"6","key":"2022070213564064600_R12","first-page":"683","article-title":"A meta-analytic study of changes in brain activation in depression","volume":"29","author":"Fitzgerald","year":"2008","journal-title":"HumanBrainMapping"},{"issue":"3","key":"2022070213564064600_R13","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1006\/nimg.1997.0291","article-title":"Psychophysiological and modulatory interactions in neuroimaging","volume":"6","author":"Friston","year":"1997","journal-title":"Neuroimage"},{"issue":"6","key":"2022070213564064600_R14","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.biopsych.2008.04.033","article-title":"Neural responses to sad facial expressions in major depression following cognitive behavioral therapy","volume":"64","author":"Fu","year":"2008","journal-title":"Biological Psychiatry"},{"issue":"6","key":"2022070213564064600_R15","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.jaac.2013.04.003","article-title":"Striatum-based circuitry of adolescent depression and anhedonia","volume":"52","author":"Gabbay","year":"2013","journal-title":"Journal of the American Academy of Child and Adolescent Psychiatry"},{"issue":"4","key":"2022070213564064600_R16","first-page":"608","article-title":"Hypofrontality and negative symptoms in major depressive disorder","volume":"39","author":"Galynker","year":"1998","journal-title":"Journal of Nuclear Medicine"},{"issue":"6","key":"2022070213564064600_R17","first-page":"577","article-title":"The neural bases of emotion regulation: reappraisal and suppression of negative emotion","volume":"63","author":"Goldin","year":"2008","journal-title":"BiologicalPsychiatry"},{"issue":"1\u20132","key":"2022070213564064600_R18","first-page":"18","article-title":"Identifying differences in biased affective information processing in major depression","volume":"159","author":"Gollan","year":"2008","journal-title":"PsychiatryResearch"},{"issue":"1","key":"2022070213564064600_R19","article-title":"Common and distinct patterns of intrinsic brain activity alterations in major depression and bipolar disorder: voxel-based meta-analysis","volume":"10","author":"Gong","year":"2020","journal-title":"TranslationalPsychiatry"},{"issue":"7","key":"2022070213564064600_R20","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1176\/appi.ajp.2012.11071105","article-title":"Functional neuroimaging of major depressive disorder: a meta-analysis and new integration of base line activation and neural response data","volume":"169","author":"Hamilton","year":"2012","journal-title":"American Journal ofPsychiatry"},{"issue":"11","key":"2022070213564064600_R21","article-title":"Subthreshold depression is associated with impaired resting-state functional connectivity of the cognitive control network","volume":"5","author":"Hwang","year":"2015","journal-title":"TranslationalPsychiatry"},{"key":"2022070213564064600_R22","article-title":"The reliability and validity of the Center for Epidemiologic Studies Depression Scale (CES-D) for Chinese university students","volume":"10","author":"Jiang","year":"2019","journal-title":"Frontiers inPsychiatry"},{"key":"2022070213564064600_R23","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.jad.2020.08.055","article-title":"Efficacy of light therapy for a college student sample with non-seasonal subthreshold depression: an RCT study","volume":"277","author":"Jiang","year":"2020","journal-title":"Journal of Affective Disorders"},{"key":"2022070213564064600_R24","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2021.755547","article-title":"Comparative efficacy of multiple therapies for the treatment of patients with subthreshold depression: a systematic review and network meta-analysis","volume":"15","author":"Jiang","year":"2021","journal-title":"Frontiers in Behavioral Neuroscience"},{"issue":"6","key":"2022070213564064600_R25","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1001\/jamapsychiatry.2015.0071","article-title":"Large-scale network dysfunction in major depressive disorder: a meta-analysis of resting-state functional connectivity","volume":"72","author":"Kaiser","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"2022070213564064600_R26","doi-asserted-by":"crossref","DOI":"10.3389\/fnhum.2018.00412","article-title":"How the dorsolateral prefrontal cortex controls affective processing in absence of visual awareness - insights from a combined EEG-rTMS study","volume":"12","author":"Keuper","year":"2018","journal-title":"Frontiers in Human Neuroscience"},{"issue":"7","key":"2022070213564064600_R27","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1097\/CHI.0b013e3181a56606","article-title":"Subthreshold depressive disorder in adolescents: predictors of escalation to full-syndrome depressive disorders","volume":"48","author":"Klein","year":"2009","journal-title":"Journal of the American Academy of Child and Adolescent Psychiatry"},{"issue":"2","key":"2022070213564064600_R28","first-page":"239","article-title":"The functional neuroanatomy of depression: distinct roles for ventromedial and dorsolateral prefrontal cortex","volume":"201","author":"Koenigs","year":"2009","journal-title":"BehaviouralBrainResearch"},{"issue":"7","key":"2022070213564064600_R29","doi-asserted-by":"crossref","first-page":"528","DOI":"10.7326\/0003-4819-144-7-200604040-00013","article-title":"Minor depression: midway between major depression and euthymia","volume":"144","author":"Kroenke","year":"2006","journal-title":"Annals of Internal Medicine"},{"key":"2022070213564064600_R30","article-title":"International affective picture system (IAPS): affective ratings of pictures and instruction manual","volume-title":"Technical Report","author":"Lang","year":"2008"},{"issue":"1\u20132","key":"2022070213564064600_R31","first-page":"29","article-title":"Altered local activity and functional connectivity of the anterior cingulate cortex in elderly individuals with subthreshold depression","volume":"222","author":"Li","year":"2014","journal-title":"PsychiatryResearch: Neuroimaging"},{"issue":"3","key":"2022070213564064600_R32","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jad.2005.08.001","article-title":"A review of the efficacy of transcranial magnetic stimulation (TMS) treatment for depression, and current and future strategies to optimize efficacy","volume":"88","author":"Loo","year":"2005","journal-title":"Journal of Affective Disorders"},{"issue":"1","key":"2022070213564064600_R33","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1177\/0706743716664885","article-title":"Systematic review of clinical practice guidelines for failed antidepressant treatment response in major depressive disorder, dysthymia, and subthreshold depression in adults","volume":"62","author":"MacQueen","year":"2017","journal-title":"The Canadian Journal ofPsychiatry"},{"issue":"3","key":"2022070213564064600_R34","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s00406-020-01123-0","article-title":"Differential neural processing of unpleasant sensory stimulation in patients with major depression","volume":"271","author":"Malejko","year":"2021","journal-title":"European Archives ofPsychiatryand Clinical Neuroscience"},{"issue":"2","key":"2022070213564064600_R35","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/02699930802204677","article-title":"Measures of emotion: a review","volume":"23","author":"Mauss","year":"2009","journal-title":"Cognition & Emotion"},{"issue":"2","key":"2022070213564064600_R36","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00127-007-0282-0","article-title":"Prevalence of depressive symptoms in university students from Germany, Denmark, Poland and Bulgaria","volume":"43","author":"Mikolajczyk","year":"2008","journal-title":"SocialPsychiatryand Psychiatric Epidemiology"},{"issue":"2","key":"2022070213564064600_R37","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3758\/s13415-011-0083-5","article-title":"Meta-analytic evidence for a superordinate cognitive control network subserving diverse executive functions","volume":"12","author":"Niendam","year":"2012","journal-title":"Cognitive, Affective & Behavioral Neuroscience"},{"issue":"4","key":"2022070213564064600_R38","first-page":"329","article-title":"Modulating emotion perception: opposing effects of inhibitory and excitatory prefrontal cortex stimulation","volume":"3","author":"Notzon","year":"2018","journal-title":"BiologicalPsychiatry: Cognitive Neuroscience andNeuroimaging"},{"issue":"5","key":"2022070213564064600_R39","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.tics.2005.03.010","article-title":"The cognitive control of emotion","volume":"9","author":"Ochsner","year":"2005","journal-title":"Trendsin Cognitive Sciences"},{"key":"2022070213564064600_R40","article-title":"A meta-analysis of changes in brain activity in clinical depression","volume":"8","author":"Palmer","year":"2014","journal-title":"Frontiers in Human Neuroscience"},{"issue":"1","key":"2022070213564064600_R41","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-74166-x","article-title":"Impaired left amygdala resting state functional connectivity in subthreshold depression individuals","volume":"10","author":"Peng","year":"2020","journal-title":"Scientific Reports"},{"issue":"3","key":"2022070213564064600_R42","first-page":"210","article-title":"Neural substrates for voluntary suppression of negative affect: a functional magnetic resonance imaging study","volume":"57","author":"Phan","year":"2005","journal-title":"BiologicalPsychiatry"},{"issue":"3","key":"2022070213564064600_R43","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.biopsycho.2012.02.007","article-title":"Brain mechanisms for emotional influences on perception and attention: what is magic and what is not","volume":"92","author":"Pourtois","year":"2013","journal-title":"Biological Psychology"},{"issue":"2","key":"2022070213564064600_R44","first-page":"213","article-title":"Cognitive control network homogeneity and executive functions in late-life depression","volume":"5","author":"Respino","year":"2020","journal-title":"BiologicalPsychiatry: Cognitive Neuroscience andNeuroimaging"},{"key":"2022070213564064600_R45","doi-asserted-by":"crossref","DOI":"10.1186\/1471-244X-12-181","article-title":"Definitions and factors associated with subthreshold depressive conditions: a systematic review","volume":"12","author":"Rodr\u00edguez","year":"2012","journal-title":"BMC Psychiatry"},{"issue":"12","key":"2022070213564064600_R46","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1002\/jclp.20629","article-title":"Major and minor depression in female adolescents: onset, course, symptom presentation, and demographic associations","volume":"65","author":"Rohde","year":"2009","journal-title":"Journal of Clinical Psychology"},{"issue":"1","key":"2022070213564064600_R47","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/npp.2011.183","article-title":"Cognitive mechanisms of treatment in depression","volume":"37","author":"Roiser","year":"2012","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"2022070213564064600_R48","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1162\/netn_a_00056","article-title":"Global connectivity of the fronto-parietal cognitive control network is related to depression symptoms in the general population","volume":"3","author":"Schultz","year":"2019","journal-title":"Network Neuroscience"},{"issue":"4","key":"2022070213564064600_R49","first-page":"296","article-title":"Amygdala and insula response to emotional images in patients with generalized social anxiety disorder","volume":"34","author":"Shah","year":"2009","journal-title":"Journal of Psychiatry & Neuroscience"},{"key":"2022070213564064600_R50","doi-asserted-by":"crossref","DOI":"10.3389\/fnhum.2012.00323","article-title":"Major depressive disorder and alterations in insular cortical activity: a review of current functional magnetic imaging research","volume":"6","author":"Sliz","year":"2012","journal-title":"Frontiers in Human Neuroscience"},{"issue":"12","key":"2022070213564064600_R51","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1176\/appi.ajp.2015.14101298","article-title":"The brain\u2019s response to reward anticipation and depression in adolescence: dimensionality, specificity, and longitudinal predictions in a community-based sample","volume":"172","author":"Stringaris","year":"2015","journal-title":"American Journal ofPsychiatry"},{"issue":"2","key":"2022070213564064600_R52","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0022-3999(02)00428-2","article-title":"Frontal-subcortical neuronal circuits and clinical neuropsychiatry: an update","volume":"53","author":"Tekin","year":"2002","journal-title":"Journal of Psychosomatic Research"},{"key":"2022070213564064600_R53","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jad.2018.08.010","article-title":"Course of subthreshold depression into a depressive disorder and its risk factors","volume":"241","author":"Tuithof","year":"2018","journal-title":"Journal of Affective Disorders"},{"issue":"2","key":"2022070213564064600_R54","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.pscychresns.2007.10.004","article-title":"Prefrontal mechanisms for executive control over emotional distraction are altered in major depression","volume":"163","author":"Wang","year":"2008","journal-title":"Psychiatry Research"},{"key":"2022070213564064600_R55","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.116692","article-title":"The pontine-driven somatic gaze tract contributes to affective processing in humans","volume":"213","author":"Wong","year":"2020","journal-title":"Neuroimage"},{"key":"2022070213564064600_R56","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jad.2020.01.135","article-title":"Subthreshold depression may exist on a spectrum with major depressive disorder: evidence from gray matter volume and morphological brain network","volume":"266","author":"Zhang","year":"2020","journal-title":"Journal of Affective Disorders"},{"key":"2022070213564064600_R57","article-title":"Dissociable posterior and anterior insula activations in processing negative stimulus before and after the application of cognitive reappraisals","volume":"11","author":"Zhang","year":"2020","journal-title":"Frontiers in Psychology"},{"key":"2022070213564064600_R58","article-title":"Connectome-based biomarkers predict subclinical depression and identify abnormal brain connections with the lateral habenula and thalamus","volume":"10","author":"Zhu","year":"2019","journal-title":"Frontiers inPsychiatry"},{"key":"2022070213564064600_R59","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.neuroimage.2014.07.003","article-title":"Inhibitory repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex modulates early affective processing","volume":"101","author":"Zwanzger","year":"2014","journal-title":"Neuroimage"}],"container-title":["Social Cognitive and Affective Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/scan\/advance-article-pdf\/doi\/10.1093\/scan\/nsac003\/42756186\/nsac003.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/scan\/article-pdf\/17\/7\/655\/44382537\/nsac003.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/scan\/article-pdf\/17\/7\/655\/44382537\/nsac003.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T13:57:36Z","timestamp":1656770256000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/scan\/article\/17\/7\/655\/6527966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,14]]},"references-count":59,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,2,14]]},"published-print":{"date-parts":[[2022,7,2]]}},"URL":"https:\/\/doi.org\/10.1093\/scan\/nsac003","relation":{},"ISSN":["1749-5016","1749-5024"],"issn-type":[{"value":"1749-5016","type":"print"},{"value":"1749-5024","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,7,1]]},"published":{"date-parts":[[2022,2,14]]}}}