{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:33:29Z","timestamp":1791502409607,"version":"4.3.4"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006952","name":"Louisiana Board of Regents","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006952","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mental imagery is involved in both the expression and treatment of fear-related disorders such as anxiety and post-traumatic stress disorder. However, the neural correlates associated with the acquisition and generalization of differential fear conditioning to imagined conditioned stimuli are relatively unknown. In this study, healthy human participants (n\u2009=\u200927) acquired differential fear conditioning to imagined conditioned stimuli paired with a physical unconditioned stimulus (i.e.\u00a0mild shock), as measured via self-reported fear, the skin conductance response and significant right anterior insula (aIn) activation. Multivoxel pattern analysis cross-classification also demonstrated that the pattern of activity in the right aIn during imagery acquisition was quantifiably similar to the pattern produced by standard visual acquisition. Additionally, mental imagery was associated with significant differential fear generalization. Fear conditioning acquired to imagined stimuli generalized to viewing those same stimuli as measured with self-reported fear and right aIn activity, and likewise fear conditioning to visual stimuli was associated with significant generalized differential self-reported fear and right aIn activity when imagining those stimuli. Together, the study provides a novel understanding of the neural mechanisms associated with the acquisition of differential fear conditioning to imagined stimuli and that of the relationship between imagery and emotion more generally.<\/jats:p>","DOI":"10.1093\/scan\/nsac063","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T17:52:59Z","timestamp":1673459579000},"source":"Crossref","is-referenced-by-count":18,"title":["Fear in the mind\u2019s eye: the neural correlates of differential fear acquisition to imagined conditioned stimuli"],"prefix":"10.1093","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6148-3769","authenticated-orcid":false,"given":"Lauryn","family":"Burleigh","sequence":"first","affiliation":[{"name":"Department of Psychology, Cognitive and Brain Sciences, Louisiana State University , Baton Rouge, LA 70803, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4578-4139","authenticated-orcid":false,"given":"Steven G","family":"Greening","sequence":"additional","affiliation":[{"name":"Department of Psychology, Cognitive and Brain Sciences, Louisiana State University , Baton Rouge, LA 70803, USA"},{"name":"Department of Psychology, Brain and Cognitive Sciences, University of Manitoba , Winnipeg, Manitoba R3T 2N2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,1,11]]},"reference":[{"key":"2023032406092140600_","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbr.2016.11.014","article-title":"Disruption of human fear reconsolidation using imaginal and in vivo extinction","volume":"319","author":"Agren","year":"2017","journal-title":"Behavioural Brain 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