{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T14:12:04Z","timestamp":1792419124128,"version":"4.5.0"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":151,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science Foundation Graduate Research Fellowship","award":["DGE 1144152"],"award-info":[{"award-number":["DGE 1144152"]}]},{"name":"Sackler Scholar Programme"},{"name":"National Science Foundation Graduate Research Fellowship","award":["DGE 1144152"],"award-info":[{"award-number":["DGE 1144152"]}]},{"name":"Sackler Scholar Programme"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The default mode network (DMN) is a network of brain regions active during rest and self-referential thinking. Individuals with major depressive disorder (MDD) show increased or decreased DMN activity relative to controls. DMN activity has been linked to a tendency to ruminate in MDD. It is unclear if individuals who are at risk for, but who have no current or past history of depression, also show differential DMN activity associated with rumination. We investigated whether females with high levels of neuroticism with no current or lifetime mood or anxiety disorders (n\u2009=\u200925) show increased DMN activation, specifically when processing negative self-referential information, compared with females with average levels of neuroticism (n\u2009=\u200928). Participants heard criticism and praise during functional magnetic resonance imaging (MRI) scans in a 3T Siemens Prisma scanner. The at-risk group showed greater activation in two DMN regions, the medial prefrontal cortex and the inferior parietal lobule (IPL), after hearing criticism, but not praise (relative to females with average levels of neuroticism). Criticism-specific activation in the IPL was significantly correlated with rumination. Individuals at risk for depression may, therefore, have an underlying neurocognitive vulnerability to use a brain network typically involved in thinking about oneself to preferentially ruminate about negative, rather than positive, information.<\/jats:p>","DOI":"10.1093\/scan\/nsad032","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T10:47:10Z","timestamp":1685530030000},"source":"Crossref","is-referenced-by-count":116,"title":["The default mode network and\u00a0rumination in\u00a0individuals at risk for\u00a0depression"],"prefix":"10.1093","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6755-7845","authenticated-orcid":false,"given":"Tina","family":"Chou","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital , Charlestown, MA 02129, USA"},{"name":"Department of Psychology, Harvard University , Cambridge, MA 02138, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thilo","family":"Deckersbach","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Applied Sciences, Diploma Hochschule , Bad Sooden-Allendorf 37242, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darin D","family":"Dougherty","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital , Charlestown, MA 02129, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill M","family":"Hooley","sequence":"additional","affiliation":[{"name":"Department of Psychology, Harvard University , Cambridge, MA 02138, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,30]]},"reference":[{"issue":"1","key":"2023061318430306100_R1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jad.2011.12.002","article-title":"Functional connectivity in\u00a0the cognitive control network and\u00a0the default mode network in\u00a0late-life depression","volume":"139","author":"Alexopoulos","year":"2012","journal-title":"Journal of Affective Disorders"},{"key":"2023061318430306100_R2","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9780890425787","volume-title":"Diagnostic and Statistical Manual of Mental Disorders (Fifth, Text Revision Ed.)","author":"American Psychiatric Association","year":"2022"},{"issue":"4","key":"2023061318430306100_R3","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/nrn1884","article-title":"Meeting of\u00a0minds: the medial frontal cortex and\u00a0social cognition","volume":"7","author":"Amodio","year":"2006","journal-title":"Nature Reviews Neuroscience"},{"issue":"10","key":"2023061318430306100_R4","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.biopsych.2005.02.021","article-title":"Activity and\u00a0connectivity of\u00a0brain mood regulating circuit in\u00a0depression: a functional magnetic resonance study","volume":"57","author":"Anand","year":"2005","journal-title":"Biological Psychiatry"},{"issue":"1","key":"2023061318430306100_R5","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1152\/jn.00830.2009","article-title":"Evidence for\u00a0the default network\u2019s role in\u00a0spontaneous cognition","volume":"104","author":"Andrews-Hanna","year":"2010","journal-title":"Journal of Neurophysiology"},{"key":"2023061318430306100_R6","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.neuron.2010.02.005","article-title":"Functional-anatomic fractionation of\u00a0the brain\u2019s default network","volume":"65","author":"Andrews-Hanna","year":"2010","journal-title":"Neuron"},{"issue":"11","key":"2023061318430306100_R7","doi-asserted-by":"crossref","first-page":"4462","DOI":"10.1002\/hbm.24285","article-title":"One MRI-compatible tDCS session attenuates ventromedial cortical perfusion when exposed to verbal criticism: the role of\u00a0perceived criticism","volume":"39","author":"Baeken","year":"2018","journal-title":"Human Brain Mapping"},{"issue":"5","key":"2023061318430306100_R8","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1093\/scan\/nsq080","article-title":"Depression, rumination and\u00a0the default network","volume":"6","author":"Berman","year":"2011","journal-title":"Social Cognitive and Affective Neuroscience"},{"issue":"12","key":"2023061318430306100_R9","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1093\/cercor\/bhp055","article-title":"Where is the semantic system? 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