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However, the mechanisms of this relationship are unknown. We examined the relationship between perceived friendship quality at age 14 after the experience of CA and reduced affective and neural responses to social exclusion at age 24. Resilient functioning was quantified as psychosocial functioning relative to the degree of CA severity in 310 participants at age 24. From this cohort, 62 young people with and without CA underwent functional Magnetic Resonance Imaging to assess brain responses to social inclusion and exclusion. We observed that good friendship quality was significantly associated with better resilient functioning. Both friendship quality and resilient functioning were related to increased affective responses to social inclusion. We also found that friendship quality, but not resilient functioning, was associated with increased dorsomedial prefrontal cortex responses to peer exclusion. Our findings suggest that friendship quality in early adolescence may contribute to the evaluation of social inclusion by increasing affective sensitivity to positive social experiences and increased brain activity in regions involved in emotion regulation to negative social experiences. Future research is needed to clarify this relationship with resilient functioning in early adulthood.<\/jats:p>","DOI":"10.1093\/scan\/nsae044","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T10:52:15Z","timestamp":1718880735000},"source":"Crossref","is-referenced-by-count":7,"title":["Early adolescent perceived friendship quality aids affective and neural responses to social inclusion and exclusion in young adults with and without adverse childhood experiences"],"prefix":"10.1093","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2873-8512","authenticated-orcid":false,"given":"Maria R","family":"Dauvermann","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Cambridge , Cambridge, CB2 8AH,","place":["United Kingdom"]},{"name":"Institute for Mental Health, University of Birmingham , Birmingham, B15 2TT,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Moreno-Lop\u00e9z","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Cambridge , Cambridge, CB2 8AH,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Vai","sequence":"additional","affiliation":[{"name":"Psychiatry & Clinical Psychobiology Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute , Milano, 20127,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Gonz\u00e1lez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Cambridge , Cambridge, CB2 8AH,","place":["United Kingdom"]},{"name":"Laboratory of Neurosciences, Hospital Infantil de M\u00e9xico Federico G\u00f3mez , Mexico City, 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