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The extent to which such associations extend beyond the specific ecology of treatment-seeking youth from upper-middle socioeconomic backgrounds is unknown. The current study tests the replicability of neuroanatomical correlates of anticipatory responding and the moderating roles of age and anxiety severity in a community sample of Latina girls, a historically underrepresented group exhibiting high levels of untreated anxiety. Forty pre-adolescent Latina girls (MAge\u2009=\u200910.01, s.d.\u2009=\u20091.25, range\u2009=\u20098\u201312\u2009years) completed a structural magnetic resonance imaging scan. Participants also completed a differential threat and safety learning paradigm, during which skin conductance and subjective fear responding were assessed. Anxiety severity was assessed via the Screen for Child Anxiety Related Emotional Disorders. Ventromedial prefrontal cortex thickness was associated with reduced physiological responsivity to anticipated threat. Age- and anxiety-dependent associations emerged between dorsomedial prefrontal cortex thickness and individual differences in subjective fear responding to anticipated threat. This preliminary study extends work on neuroanatomical contributions to physiological threat responsivity to a community sample of Latina youth and highlights potential considerations for early identification efforts in this population when threat neurocircuitry is still developing.<\/jats:p>","DOI":"10.1093\/scan\/nsae065","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T05:06:27Z","timestamp":1732079187000},"source":"Crossref","is-referenced-by-count":1,"title":["A preliminary study of threat-anticipatory responding in Latina youth: associations with age, anxiety, and cortical thickness"],"prefix":"10.1093","volume":"19","author":[{"given":"Jordan L","family":"Mullins","sequence":"first","affiliation":[{"name":"Department of Psychology, University of California, Riverside , Riverside, CA 92521,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rany","family":"Abend","sequence":"additional","affiliation":[{"name":"School of Psychology, Reichman University , Herzliya 4610101,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4830-5036","authenticated-orcid":false,"given":"Kalina J","family":"Michalska","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of California, Riverside , Riverside, CA 92521,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"2024112505005554900_R1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2023.105305","article-title":"Understanding anxiety symptoms as aberrant defensive responding along the threat imminence continuum","volume":"152","author":"Abend","year":"2023","journal-title":"Neurosci Biobehav Rev"},{"key":"2024112505005554900_R2","doi-asserted-by":"publisher","first-page":"E212","DOI":"10.1503\/jpn.200110","article-title":"Threat-anticipatory psychophysiological response is enhanced in youth with anxiety disorders and correlates with prefrontal cortex neuroanatomy","volume":"46","author":"Abend","year":"2021","journal-title":"J Psychiatry Neurosci"},{"key":"2024112505005554900_R3","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.66169","article-title":"Computational modeling of threat learning reveals links with anxiety and neuroanatomy in humans","volume":"11","author":"Abend","year":"2022","journal-title":"Elife"},{"key":"2024112505005554900_R4","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1016\/j.biopsych.2019.11.006","article-title":"Anticipatory threat responding: associations with anxiety, development, and brain structure","volume":"87","author":"Abend","year":"2020","journal-title":"Biol Psychiatry"},{"key":"2024112505005554900_R5","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19167-0","article-title":"Over-activation of primate subgenual cingulate cortex enhances the cardiovascular, behavioral and neural responses to threat","volume":"11","author":"Alexander","year":"2020","journal-title":"Nat Commun"},{"key":"2024112505005554900_R6","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2013","edition":"5th"},{"key":"2024112505005554900_R7","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.cpr.2009.12.008","article-title":"Race\/ethnicity and internalizing disorders in youth: a review","volume":"30","author":"Anderson","year":"2010","journal-title":"Clinic Psychol Rev"},{"key":"2024112505005554900_R8","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1001\/archpsyc.1987.01800130081010","article-title":"DSM-III disorders in preadolescent children. 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