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This study focuses on the abnormality in processing real-life emotional stimuli among individuals with MD. Thirty-two individuals with MD and 31 normal controls (NC) were recruited and underwent comprehensive clinical interview, cognitive assessment, and magnetic resonance imaging (MRI) scans. During functional MRI scanning, subjects watched positive, negative, and neutral emotional movie clips. We used the inter-subject correlation and inter-subject functional connectivity analysis to investigate the neural differentiation between MD and NC during film viewing. The relationships between neural differentiation, symptom severity, and psychological resilience were analysed. We found that neural differentiations between individuals with MD and NC in the post cingulate cortex (PCC) and precuneus (PCUN) were consistent across three emotional conditions. Notably, the similarity of neural responses in the PCC and PCUN with NC but not MD was negatively correlated with depressive symptoms. Furthermore, this neural similarity mediated the relationship between psychological resilience and depression severity. Our findings support that the PCC and PCUN, two core areas of the default mode network, play a critical role in MD\u2019s emotion processing deficit.<\/jats:p>","DOI":"10.1093\/scan\/nsae086","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T07:03:38Z","timestamp":1732518218000},"source":"Crossref","is-referenced-by-count":5,"title":["Neural divergence between individuals with and without minor depression during dynamic emotion processing: a movie-fMRI Study"],"prefix":"10.1093","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6841-2314","authenticated-orcid":false,"given":"Manqi","family":"Zhang","sequence":"first","affiliation":[{"name":"Center for Studies of Psychological Application, South China Normal University , Guangzhou 510631,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjie","family":"Deng","sequence":"additional","affiliation":[{"name":"The Affiliated 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