{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:18:53Z","timestamp":1792466333706,"version":"4.5.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T00:00:00Z","timestamp":1476316800000},"content-version":"vor","delay-in-days":241,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["oxfordjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,5,1]]},"DOI":"10.1093\/scan\/nsw019","type":"journal-article","created":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T01:39:18Z","timestamp":1455673158000},"page":"843-851","update-policy":"https:\/\/doi.org\/10.1093\/policy","source":"Crossref","is-referenced-by-count":54,"title":["Habenula responses to potential and actual loss in major depression: preliminary evidence for lateralized dysfunction"],"prefix":"10.1093","volume":"11","author":[{"given":"Daniella J.","family":"Furman","sequence":"first","affiliation":[{"name":"Department of Psychology, Stanford University, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian H.","family":"Gotlib","sequence":"additional","affiliation":[{"name":"Department of Psychology, Stanford University, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,2,15]]},"reference":[{"issue":"2","key":"key\n\t\t\t\t2018121304072824300_nsw019-B1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1037\/0022-3514.52.2.366","article-title":"Depression and pessimism for the future: biased use of statistically relevant information in predictions for self versus others","volume":"52","author":"Alloy","year":"1987","journal-title":"Journal of Personality and Social Psychology"},{"issue":"1","key":"key\n\t\t\t\t2018121304072824300_nsw019-B2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1348\/014466502163778","article-title":"Predicting depressive symptoms with a new measure of shame: the Experience of Shame Scale","volume":"41","author":"Andrews","year":"2002","journal-title":"British Journal of Clinical Psychology"},{"issue":"6","key":"key\n\t\t\t\t2018121304072824300_nsw019-B3","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/cne.22561","article-title":"The inhibitory influence of the lateral habenula on midbrain dopamine cells: ultrastructural evidence for indirect mediation via the rostromedial mesopontine tegmental nucleus","volume":"519","author":"Balcita-Pedicino","year":"2011","journal-title":"Journal of Comparative Neurology"},{"key":"key\n\t\t\t\t2018121304072824300_nsw019-B4","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1017\/S0033291700035662","article-title":"Cognitive performance in tests sensitive to frontal lobe dysfunction in the elderly depressed","volume":"26","author":"Beats","year":"1996","journal-title":"Psychological Medicine"},{"key":"key\n\t\t\t\t2018121304072824300_nsw019-B5","volume-title":"Beck Depression Inventory-II (BDI-II)","author":"Beck","year":"1996"},{"issue":"11","key":"key\n\t\t\t\t2018121304072824300_nsw019-B6","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1212\/WNL.0000000000001937","article-title":"Habenula Recently recognized functions and potential clinical relevance","volume":"85","author":"Benarroch","year":"2015","journal-title":"Neurology"},{"issue":"1519","key":"key\n\t\t\t\t2018121304072824300_nsw019-B7","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1098\/rstb.2008.0213","article-title":"The habenular nuclei: a conserved asymmetric relay station in the vertebrate brain","volume":"364","author":"Bianco","year":"2009","journal-title":"Philosophical Transactions of the Royal Society B: Biological Sciences"},{"issue":"6","key":"key\n\t\t\t\t2018121304072824300_nsw019-B8","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1523\/JNEUROSCI.08-06-01951.1988","article-title":"Cerebral correlates of depressed behavior in rats, visualized using 14C-2-deoxyglucose autoradiography","volume":"8","author":"Caldecott-Hazard","year":"1988","journal-title":"The Journal of Neuroscience"},{"issue":"4","key":"key\n\t\t\t\t2018121304072824300_nsw019-B9","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1176\/ajp.2007.164.4.608","article-title":"Neural evidence for enhanced error detection in major depressive disorder","volume":"164","author":"Chiu","year":"2007","journal-title":"American Journal of Psychiatry"},{"issue":"1\u20132","key":"key\n\t\t\t\t2018121304072824300_nsw019-B10","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1046\/j.1469-7580.2001.19910063.x","article-title":"Asymmetry in the epithalamus of vertebrates","volume":"199","author":"Concha","year":"2001","journal-title":"Journal of Anatomy"},{"issue":"3","key":"key\n\t\t\t\t2018121304072824300_nsw019-B11","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/cbmr.1996.0014","article-title":"AFNI: software for analysis and visualization of functional magnetic resonance neuroimages","volume":"29","author":"Cox","year":"1996","journal-title":"Computers and Biomedical Research"},{"issue":"5867","key":"key\n\t\t\t\t2018121304072824300_nsw019-B12","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1126\/science.1150605","article-title":"BOLD responses reflecting dopaminergic signals in the human ventral tegmental area","volume":"319","author":"D\u2019Ardenne","year":"2008","journal-title":"Science"},{"key":"key\n\t\t\t\t2018121304072824300_nsw019-B13","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jad.2009.02.018","article-title":"Abnormal response to failure in unmedicated major depression","volume":"119","author":"Douglas","year":"2009","journal-title":"Journal of Affective Disorders"},{"key":"key\n\t\t\t\t2018121304072824300_nsw019-B14","volume-title":"SCID-I-TR: Structured Clinical Interview for DSM-IV-TR Disorders","author":"First","year":"2001"},{"issue":"1","key":"key\n\t\t\t\t2018121304072824300_nsw019-B15","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1523\/JNEUROSCI.0927-14.2015","article-title":"Distinct midbrain and habenula pathways are involved in processing aversive events in humans","volume":"35","author":"Hennigan","year":"2015","journal-title":"The Journal of Neuroscience"},{"issue":"7","key":"key\n\t\t\t\t2018121304072824300_nsw019-B16","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nrn2866","article-title":"The habenula: from stress evasion to value-based decision-making","volume":"11","author":"Hikosaka","year":"2010","journal-title":"Nature Reviews Neuroscience"},{"issue":"2","key":"key\n\t\t\t\t2018121304072824300_nsw019-B17","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1001\/archgenpsychiatry.2007.19","article-title":"Spatiotemporal dynamics of error processing dysfunctions in major depressive disorder","volume":"65","author":"Holmes","year":"2008","journal-title":"Archives of General Psychiatry"},{"issue":"5","key":"key\n\t\t\t\t2018121304072824300_nsw019-B18","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.cortex.2007.08.013","article-title":"Dorsal anterior cingulate cortex integrates reinforcement history to guide voluntary behavior","volume":"44","author":"Holroyd","year":"2008","journal-title":"Cortex"},{"issue":"4","key":"key\n\t\t\t\t2018121304072824300_nsw019-B19","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.neuron.2008.09.035","article-title":"The globus pallidus sends reward-related signals to the lateral habenula","volume":"60","author":"Hong","year":"2008","journal-title":"Neuron"},{"key":"key\n\t\t\t\t2018121304072824300_nsw019-B20","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fnhum.2011.00025","article-title":"Error-related functional connectivity of the habenula in humans","volume":"5","author":"Ide","year":"2011","journal-title":"Frontiers in Human Neuroscience"},{"issue":"5","key":"key\n\t\t\t\t2018121304072824300_nsw019-B21","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.neuron.2009.02.001","article-title":"The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses","volume":"61","author":"Jhou","year":"2009","journal-title":"Neuron"},{"issue":"26","key":"key\n\t\t\t\t2018121304072824300_nsw019-B22","doi-asserted-by":"crossref","first-page":"6923","DOI":"10.1523\/JNEUROSCI.0958-07.2007","article-title":"Lateral habenula stimulation inhibits rat midbrain dopamine neurons through a GABAA receptor-mediated mechanism","volume":"27","author":"Ji","year":"2007","journal-title":"The Journal of Neuroscience"},{"key":"key\n\t\t\t\t2018121304072824300_nsw019-B23","first-page":"7","article-title":"Epidemiology of depression","volume-title":"Handbook of Depression","author":"Kessler","year":"2014","edition":"3nd edn"},{"issue":"7","key":"key\n\t\t\t\t2018121304072824300_nsw019-B24","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.biopsych.2007.07.023","article-title":"Neural responses to monetary incentives in major depression","volume":"63","author":"Knutson","year":"2008","journal-title":"Biological Psychiatry"},{"issue":"7423","key":"key\n\t\t\t\t2018121304072824300_nsw019-B25","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/nature11527","article-title":"Input-specific control of reward and aversion in the ventral tegmental area","volume":"491","author":"Lammel","year":"2012","journal-title":"Nature"},{"key":"key\n\t\t\t\t2018121304072824300_nsw019-B26","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.neuroimage.2012.08.076","article-title":"Defining the habenula in human neuroimaging studies","volume":"64","author":"Lawson","year":"2012","journal-title":"NeuroImage"},{"issue":"32","key":"key\n\t\t\t\t2018121304072824300_nsw019-B27","doi-asserted-by":"crossref","first-page":"11858","DOI":"10.1073\/pnas.1323586111","article-title":"The habenula encodes negative motivational value associated with primary punishment in humans","volume":"111","author":"Lawson","year":"2014","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"7","key":"key\n\t\t\t\t2018121304072824300_nsw019-B28","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1111\/ejn.12480","article-title":"The lateral habenula in addiction and depression: an anatomical, synaptic and behavioral overview","volume":"39","author":"Lecca","year":"2014","journal-title":"European Journal of Neuroscience"},{"issue":"7335","key":"key\n\t\t\t\t2018121304072824300_nsw019-B29","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nature09742","article-title":"Synaptic potentiation onto habenula neurons in the learned helplessness model of depression","volume":"470","author":"Li","year":"2011","journal-title":"Nature"},{"issue":"4","key":"key\n\t\t\t\t2018121304072824300_nsw019-B30","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.neuroscience.2008.06.062","article-title":"Error-specific medial cortical and subcortical activity during the stop signal task: a functional magnetic resonance imaging study","volume":"155","author":"Li","year":"2008","journal-title":"Neuroscience"},{"issue":"7148","key":"key\n\t\t\t\t2018121304072824300_nsw019-B31","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/nature05860","article-title":"Lateral habenula as a source of negative reward signals in dopamine neurons","volume":"447","author":"Matsumoto","year":"2007","journal-title":"Nature"},{"issue":"1","key":"key\n\t\t\t\t2018121304072824300_nsw019-B32","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nn.2233","article-title":"Representation of negative motivational value in the primate lateral habenula","volume":"12","author":"Matsumoto","year":"2008","journal-title":"Nature Neuroscience"},{"key":"key\n\t\t\t\t2018121304072824300_nsw019-B33","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.brainres.2011.08.041","article-title":"Chronic deep brain stimulation of the lateral habenula nucleus in a rat model of depression","volume":"1422","author":"Meng","year":"2011","journal-title":"Brain research"},{"issue":"4","key":"key\n\t\t\t\t2018121304072824300_nsw019-B34","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1017\/S0033291701003804","article-title":"Decision-making cognition in mania and depression","volume":"31","author":"Murphy","year":"2001","journal-title":"Psychological Medicine"},{"issue":"2","key":"key\n\t\t\t\t2018121304072824300_nsw019-B35","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jad.2005.12.005","article-title":"Sensitivity to reward and punishment and the prefrontal cortex in major depression","volume":"90","author":"Must","year":"2006","journal-title":"Journal of Affective Disorders"},{"key":"key\n\t\t\t\t2018121304072824300_nsw019-B36","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.brainres.2012.10.011","article-title":"DREADDing the lateral habenula: a review of methodological approaches for studying lateral habenula function","volume":"1511","author":"Nair","year":"2012","journal-title":"Brain Research"},{"issue":"1","key":"key\n\t\t\t\t2018121304072824300_nsw019-B37","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1037\/0022-3514.61.1.115","article-title":"A prospective study of depression and posttraumatic stress symptoms after a natural disaster: the 1989 Loma Prieta earthquake","volume":"61","author":"Nolen-Hoeksema","year":"1991","journal-title":"Journal of Personality and Social Psychology"},{"issue":"9","key":"key\n\t\t\t\t2018121304072824300_nsw019-B38","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/nn.3779","article-title":"Reward processing by the lateral habenula in normal and depressive behaviors","volume":"17","author":"Proulx","year":"2014","journal-title":"Nature Neuroscience"},{"issue":"5","key":"key\n\t\t\t\t2018121304072824300_nsw019-B39","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.biopsych.2009.05.002","article-title":"The effects of tryptophan depletion on neural responses to emotional words in remitted depression","volume":"66","author":"Roiser","year":"2009","journal-title":"Biological Psychiatry"},{"key":"key\n\t\t\t\t2018121304072824300_nsw019-B40","first-page":"36","article-title":"BOLD responses to negative reward prediction errors in human habenula","volume":"4","author":"Salas","year":"2010","journal-title":"Frontiers in Human Neuroscience"},{"issue":"2","key":"key\n\t\t\t\t2018121304072824300_nsw019-B41","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1016\/j.biopsych.2009.08.027","article-title":"Remission of major depression under deep brain stimulation of the lateral habenula in a therapy-refractory patient","volume":"67","author":"Sartorius","year":"2010","journal-title":"Biological Psychiatry"},{"issue":"2","key":"key\n\t\t\t\t2018121304072824300_nsw019-B42","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.jad.2013.06.016","article-title":"Remitted major depression is characterized by reduced prefrontal cortex reactivity to reward loss","volume":"151","author":"Schiller","year":"2013","journal-title":"Journal of Affective Disorders"},{"issue":"1","key":"key\n\t\t\t\t2018121304072824300_nsw019-B43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/jn.1998.80.1.1","article-title":"Predictive reward signal of dopamine neurons","volume":"80","author":"Schultz","year":"1998","journal-title":"Journal of Neurophysiology"},{"issue":"3","key":"key\n\t\t\t\t2018121304072824300_nsw019-B44","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.neuron.2012.02.037","article-title":"Input to the lateral habenula from the basal ganglia is excitatory, aversive, and suppressed by serotonin","volume":"74","author":"Shabel","year":"2012","journal-title":"Neuron"},{"issue":"10","key":"key\n\t\t\t\t2018121304072824300_nsw019-B45","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1152\/jn.00012.2012","article-title":"Mapping pain activation and connectivity of the human habenula","volume":"107","author":"Shelton","year":"2012","journal-title":"Journal of Neurophysiology"},{"issue":"3","key":"key\n\t\t\t\t2018121304072824300_nsw019-B46","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/schbul\/sbj083","article-title":"Schizophrenia in translation: the presence of absence: habenular regulation of dopamine neurons and the encoding of negative outcomes","volume":"32","author":"Shepard","year":"2006","journal-title":"Schizophrenia Bulletin"},{"issue":"1\u20132","key":"key\n\t\t\t\t2018121304072824300_nsw019-B47","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0006-8993(02)04048-9","article-title":"Opposite metabolic changes in the habenula and ventral tegmental area of a genetic model of helpless behavior","volume":"963","author":"Shumake","year":"2003","journal-title":"Brain Research"},{"issue":"9","key":"key\n\t\t\t\t2018121304072824300_nsw019-B48","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1093\/brain\/awm150","article-title":"Blunted response to feedback information in depressive illness","volume":"130","author":"Steele","year":"2007","journal-title":"Brain"},{"issue":"6","key":"key\n\t\t\t\t2018121304072824300_nsw019-B49","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.brat.2005.07.001","article-title":"Depressive symptoms are associated with unrealistic negative predictions of future life events","volume":"44","author":"Strunk","year":"2006","journal-title":"Behaviour Research and Therapy"},{"issue":"3","key":"key\n\t\t\t\t2018121304072824300_nsw019-B50","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1023\/A:1023910315561","article-title":"Rumination reconsidered: a psychometric analysis","volume":"27","author":"Treynor","year":"2003","journal-title":"Cognitive Therapy and Research"},{"issue":"10","key":"key\n\t\t\t\t2018121304072824300_nsw019-B51","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.1523\/JNEUROSCI.23-10-04308.2003","article-title":"Error monitoring using external feedback: specific roles of the habenular complex, the reward system, and the cingulate motor area revealed by functional magnetic resonance imaging","volume":"23","author":"Ullsperger","year":"2003","journal-title":"The Journal of Neuroscience"},{"issue":"4","key":"key\n\t\t\t\t2018121304072824300_nsw019-B52","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/cpp.651","article-title":"Decision making in depression: differences in decisional conflict between healthy and depressed individuals","volume":"17","author":"van Randenborgh","year":"2010","journal-title":"Clinical Psychology and Psychotherapy"},{"issue":"6","key":"key\n\t\t\t\t2018121304072824300_nsw019-B53","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1037\/0022-3514.54.6.1063","article-title":"Development and validation of brief measures of positive and negative affect: the PANAS scales","volume":"54","author":"Watson","year":"1988","journal-title":"Journal of Personality and Social Psychology"},{"issue":"1","key":"key\n\t\t\t\t2018121304072824300_nsw019-B54","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.bbr.2010.07.034","article-title":"Pharmacological inhibition of the lateral habenula improves depressive-like behavior in an animal model of treatment resistant depression","volume":"216","author":"Winter","year":"2011","journal-title":"Behavioural Brain Research"},{"key":"key\n\t\t\t\t2018121304072824300_nsw019-B55","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.bbr.2014.09.016","article-title":"The role of lateral habenula\u2013dorsal raphe nucleus circuits in higher brain functions and psychiatric illness","volume":"277","author":"Zhao","year":"2015","journal-title":"Behavioural Brain Research"}],"container-title":["Social Cognitive and Affective Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/scan\/article-pdf\/11\/5\/843\/27103305\/nsw019.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T11:50:45Z","timestamp":1718365845000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/scan\/article\/11\/5\/843\/1753513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,15]]},"references-count":55,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,2,15]]},"published-print":{"date-parts":[[2016,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/scan\/nsw019","relation":{},"ISSN":["1749-5024","1749-5016"],"issn-type":[{"value":"1749-5024","type":"electronic"},{"value":"1749-5016","type":"print"}],"subject":[],"published-other":{"date-parts":[[2016,5]]},"published":{"date-parts":[[2016,2,15]]}}}