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However, to date, our perspective of brain-behavior relationships has been informed solely by cross-sectional correlational studies linking behavior in the lab to brain structure or respective resting-state network connectivity. Here, we assess movement dysfunction from 2 perspectives: study 1 investigates the longitudinal progression of handwriting variability and positive symptoms in a sample of 91 CHR and healthy controls during a 12-month follow-up and study 2 involves a multiband functional magnetic resonance imaging task exploring the relationship between power grip force stability and motor network brain activation in a subset of participants. In study 1, we found that greater handwriting variability was a stable feature of CHR participants who experienced worse symptom progression. Study 2 results showed that CHR individuals had greater variability in their grip force and greater variability was related to decreased activation in the associative cortico-striatal network compared to controls. Motor variability may be a stable marker of vulnerability for psychosis risk and possible indicator of a vulnerable cortico-striatal brain network functioning in CHR participants, although the effects of antipsychotic medication should be considered.<\/jats:p>","DOI":"10.1093\/schbul\/sbaa072","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T15:49:11Z","timestamp":1589816951000},"page":"1567-1576","source":"Crossref","is-referenced-by-count":11,"title":["Longitudinal Assessment and Functional Neuroimaging of Movement Variability Reveal Novel Insights Into Motor Dysfunction in Clinical High Risk for Psychosis"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8599-773X","authenticated-orcid":false,"given":"Derek J","family":"Dean","sequence":"first","affiliation":[{"name":"Department of Psychology, Vanderbilt University, Nashville, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A","family":"Bernard","sequence":"additional","affiliation":[{"name":"Department of Psychological and Brain Sciences, Texas A&M University, College Station, TX"},{"name":"Institute for Neuroscience, Texas A&M University, College Station, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine S F","family":"Damme","sequence":"additional","affiliation":[{"name":"Department of Psychology, Northwestern University, Evanston, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall","family":"O\u2019Reilly","sequence":"additional","affiliation":[{"name":"Departments of Psychology, Computer Science, and Center for Neuroscience, University of California Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M","family":"Orr","sequence":"additional","affiliation":[{"name":"Department of Psychological and Brain Sciences, Texas A&M University, College Station, TX"},{"name":"Institute for Neuroscience, Texas A&M 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